Timing of Prenatal Stressors and Autism Abstract
Recent evidence supports a role for genetics in autism, but other findings are difficult to reconcile with a purely genetic cause. Pathological changes in the cerebellum in autism are thought to correspond to an event before 30–32 weeks gestation. Our purpose was to determine whether there is an increased incidence of stressors in autism before this time period. Surveys regarding incidence and timing of prenatal stressors were distributed to specialized schools and clinics for autism and Down syndrome, and to mothers of children without neurodevelopmental diagnoses in walk-in clinics. Incidence of stressors during each 4-week block of pregnancy was recorded. Incidence of stressors in the blocks prior to and including the predicted time period (21–32 weeks gestation) in each group of surveys was compared to the other prenatal blocks. A higher incidence of prenatal stressors was found in autism at 21–32 weeks gestation, with a peak at 25–28 weeks. This does support the possibility of prenatal stressors as a potential contributor to autism, with the timing of stressors consistent with the embryological age suggested by neuroanatomical findings seen in the cerebellum in autism. Future prospective studies would be needed to confirm this finding.
Keywords Autism prenatal stress development References Ahlbom, E., Gogvadze, V., Chen, M., Celsi, G., Ceccatelli, S. 2000 Prenatal exposure to high levels of glucocorticoids increases the susceptibility of cerebellar granule cells to oxidative stress-induced cell death Proceedings of the National Academy of Sciences of the United States of America 97 14726 14730 CrossRef PubMed Google Scholar American Psychological Association 1995Diagnostic and statistical manual of mental disorders4 American Psychological Association Washington Google Scholar Aylward, E. H., Minshew, N. J., Goldstein, G., Honeycutt, N. A., Augustine, A. M., Yates, K. O., Barta, P. E., Pearlson, G. D. 1999 MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults Neurology 53 2145 2150 PubMed Google Scholar Bachevalier, J. 1991 An animal model for childhood autism Tamminga, C. A. Schultz, S. C. eds. Advances in neuropsychiatry and psychopharmology, Vol 1: schizophrenia research Raven Press New York 129 140 Google Scholar Bailey, A., Luthert, P., Dean, A., Harding, B., Janota, I., Montgomery, M., Rutter, M., Lantos, P. 1998 A clinicopathological study of autism Brain 121 889 905 CrossRef PubMed Google Scholar Bauman, M. L., Kemper, T. L. 1994 Neuroanatomic observations of the brain in autism Bauman, M. L. Kemper, T. L. eds. The neurobiology of autism Johns Hopkins University Press Baltimore 119 145 Google Scholar Burd, L., Severud, R., Kerbeshian, J., Klug, M. G. 1999 Prenatal and perinatal risk factors for autism Journal of Perinatal Medicine 27 441 450 CrossRef PubMed Google Scholar Casey, R. L., Masuda, M., Holmes, T. H. 1967 Quantitative study of recall of life events Journal of Psychosomatic Research 11 239 247 CrossRef PubMed Google Scholar Courchesne, C., Townsend, J., Saitoh, O. 1999 The brain in infantile autism: posterior fossa structures are abnormal Neurology 44 214 223 Google Scholar Davis, E., Fennoy, I., Laraque, D., Kanem, N., Brown, G., Mitchell, J. 1992 Autism and developmental abnormalities in children with perinatal cocaine exposure Journal of the National Medical Association 84 315 319 PubMed Google Scholar Dawson, G., Ashman, S. B., Carver, L. J. 2000 The role of early experience in shaping behavioral and brain development and its implications for social policy Developmental Psychopathology 12 695 712 CrossRef Google Scholar Fleischig, P. 1920Anatomie des Menchlichen Gehim und Ruchnmachs auf Myelogenetischer Grundlage George Thieme Leipzig Google Scholar Folstein, S., Rutter, M. 1977 Infantile autism: A genetic study of 21 twin pairs Journal of Child Psychology and Psychiatry and Allied Disciplines 18 297 321 Google Scholar Gillberg, C. 1990 Do children with autism have March birthdays? Acta Psychiatrica Scandinavica 82 152 156 PubMed Google Scholar Holmes, T. H., Rahe, R. H. 1967 The social readjustment rating scale Journal of Psychosomatic Research 11 213 218 CrossRef PubMed Google Scholar Hultman, C. M., Sparén, P., Cnattingius, S. 2002 Perinatal risk factors for infantile autism Epidemiology 13 417 423 CrossRef PubMed Google Scholar Kates, W. R., Mostofsky, S. H., Zimmerman, A. W., Mazzocco, M. M., Landa, R., Warsofsky, I. S., Kaufman, W. E., Reiss, A. L. 1998 Neuroanatomical and neurocognitive differences in a pair of monozygous twins discordant for autism Annals of Neurology 43 782 791 CrossRef PubMed Google Scholar LeDoux, J. E. 2000 Emotion circuits in the brain Annual Review of Neuroscience 23 155 184 CrossRef PubMed Google Scholar Maestrini, E., Paul, A., Monaco, A. P., Bailey, A. 2000 Identifying autism susceptibility genes Neuron 28 19 24 CrossRef PubMed Google Scholar Masuda, M., Holmes, T. H. 1967 Magnitude estimation of social readjustments Journal of Psychosomatic Research 11 219 225 CrossRef PubMed Google Scholar Mouridsen, E., Nielsen, S., Rich, B., Isages, T. 1994 Season of birth in infantile autism and other types of childhood psychoses Child Psychiatry and Human Development 25 31 43 PubMed Google Scholar Niederhofer, H., Reiter, A. 2000 Maternal stress during pregnancy, its objectivation by ultrasound observation of fetal intrauterine movements and child’s temperament at 6 months and 6 years of age: A pilot study Psychological Reports 86 526 528 PubMed Google Scholar Piven, J., Palmer, P. 1999 Psychiatric disorder and the broad autism phenotype: Evidence from a family study of multiple-incidence autism families American Journal of Psychiatry 156 557 563 PubMed Google Scholar Rakic, P., Sidman, R. L. 1970 Histogenesis of the cortical layers in human cerebellum particularly the lamina dissecans Journal of Comparative Neurology 139 473 500 CrossRef PubMed Google Scholar Rakic, P. 1971 Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electron microscopic study in macacus rhesus Journal of Comparative Neurology 141 282 312 CrossRef Google Scholar Ritvo, E. R., Freeman, B. J., Mason-Brothers, A., Mo, A., Ritvo, A. M. 1985 Concordance for the syndrome of autism in 40 pairs of afflicted twins American Journal of Psychiatry 142 74 77 PubMed Google Scholar Salm, A. K., Pavelko, M., Krouse, E. M., Webster, W., Kraszpulski, M., Birkle, D. L. 2004 Lateral amygdaloid nucleus expansion in adult rats is associated with exposure to prenatal stress Developmental Brain Research 148 159 167 CrossRef PubMed Google Scholar Schmahmann, J. D. 1994 Neuroanatomic observations of the brain in autism Bauman, M. L. Kemper, T. L. eds. The neurobiology of autism Johns Hopkins University Press Baltimore 195 226 Google Scholar Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., Maravilla, K. R., Giedd, J. N., Munson, J., Dawson, G., Dager, S. R. 2002 Brain structural abnormalities in young children with autism spectrum disorder Neurology 59 184 192 PubMed Google Scholar Steffenburg, S., Gillberg, C., Hellgren, L., Jakobsson, G., Bohman, M. 1989 A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden Journal of Child Psychology and Psychiatry and Allied Disciplines 30 405 416 Google Scholar Strömland, K., Nordin, V., Miller, M., Åkerström, B., Gillberg, C. 1994 Autism in thalidomide embryopathy: A population study Developmental Medicine and Child Neurology 36 351 356 PubMed Google Scholar Takahashi, L. K., Baker, E. W., Kalin, N. H. 1990 Ontogeny of behavioral and hormonal responses to stress in prenatally stressed male rat pups Physiology and Behavior 47 357 364 CrossRef PubMed Google Scholar Takahashi, L. K., Haglin, C., Kalin, N. H. 1992 Prenatal stress potentiates stress-induced behavior and reduces the propensity to play in juvenile rats Physiology and Behavior 51 319 323 CrossRef PubMed Google Scholar Takahashi, L. K., Kalin, N. H., Barksdale, C. M., Vanden Burgt, J.␣A., Brownfield, M. S. 1988 Stressor controllability during pregnancy influences pituitary–adrenal hormone concentrations and analgesic responsiveness in offspring Physiology and Behavior 42 323 329 CrossRef PubMed Google Scholar Takahashi, L. K., Kalin, N. H. 1991 Early developmental and temporal characteristics of stress-induced secretion of pituitary–adrenal hormones in prenatally stressed rat pups Brain Research 558 75 78 CrossRef PubMed Google Scholar Trottier, G., Srivastava, L., Walker, C. D. 1999 Etiology of infantile autism: A review of recent advances in genetic and neurobiological research Journal of Psychiatry and Neuroscience 24 103 115 PubMed Google Scholar Os, J., Selten, J. P. 1998 Prenatal exposure to maternal stress and subsequent schizophrenia – the May 1940 invasion of The Netherlands British Journal of Psychiatry 172 324 326 PubMed Google Scholar Ward, A. J. 1990 A comparison and analysis of the presence of family problems during pregnancy of mothers of “autistic” children and mothers of typically developing children Child Psychiatry and Human Development 20 279 288 CrossRef PubMed Google Scholar Ward, A. J. 1991 Prenatal stress and child psychopathology Child Psychiatry and Human Development 22 97 110 CrossRef PubMed Google Scholar Ward, H. E., Johnson, E. A., Salm, A. K., Birkle, D. L. 2000 Effects of prenatal stress on defensive withdrawal behavior and corticotropin releasing factor systems in rat brain Physiology and Behavior 70 359 366 CrossRef PubMed Google Scholar Weinstock, M. 1997 Does prenatal stress impair coping and regulation of hypothalamic–pituitary–adrenal axis? Neuroscience and Biobehavioral Reviews 21 1 10 CrossRef PubMed Google Scholar Williams, G., King, J., Cunningham, M., Stephan, M., Kerr, B., Hersh, J. H. 2001 Fetal valproate syndrome and autism: Additional evidence of an association Developmental Medicine and Child Neurology 43 202 206 CrossRef PubMed Google Scholar Yakovlev, P. I., Lecours, A. R. 1967 Myelogenic cycles of regional maturation of the brain Minkowski, A. eds. Regional development of the brain in early life Blackwell Scientific Publications Oxford 3 70 Google Scholar Zwaigenbaum, L., Szatmari, P., Jones, M. B., Bryson, S. E., MacLean, J. E., Mahoney, W. J., Bartolucci, G., Tuff, L. 2002 Pregnancy and birth complications in autism and liability to the broader autism phenotype Journal of the American Academy of Child and Adolescent Psychiatry 41 572 579 CrossRef PubMed Google Scholar Copyright information
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