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Verbal and Spatial Working Memory in Autism

  • Diane L. Williams
  • Gerald Goldstein
  • Patricia A. Carpenter
  • Nancy J. Minshew
Article

Abstract

Verbal and spatial working memory were examined in high-functioning children, adolescents, and adults with autism compared to age and cognitive-matched controls. No deficit was found in verbal working memory in the individuals with autism using an N-back letter task and standardized measures. The distinction between the N-back task and others used previously to infer a working memory deficit in autism is that this task does not involve a complex cognitive demand. Deficits were found in spatial working memory. Understanding the basis for the dissociation between intact verbal working memory and impaired spatial working memory and the breakdown that occurs in verbal working memory as information processing demands are increased will likely provide valuable insights into the neural basis of autism.

Autism working memory information processing 

Notes

ACKNOWLEDGMENTS

The National Institute of Child Health and Human Development Grant HD35469 to Nancy J. Minshew supported this research. This study was supported by an NICHD Collaborative Program of Excellence in Autism (CPEA). The Medical Research Service, Department of Veterans Affairs is also acknowledged for support of this research. Diane L. Williams was supported by National Institute of Mental Health Grant T32-MH18951.

References

  1. Baddeley A., (1986). Working memory New York: Oxford University PressGoogle Scholar
  2. Baddeley A., (1992). Is working memory working? Quarterly Journal of Experimental Psychology: Human Experimental Psychology 44A(1): 1–31Google Scholar
  3. Bauman M. L., Kemper T. L., (1990). Limbic and cerebellar abnormalities are also present in an autistic child of normal intelligence Neurology 40: 359Google Scholar
  4. Bauman M. L., Kemper T. L., (1994). Neuroanatomic observations of the brain in autism. In Bauman M. L., Kemper T. L., (Eds), The neurobiology of autism. Baltimore: Johns Hopkins University Press. pp. 119–145Google Scholar
  5. Bennetto L., Pennington B. F., Rogers S. J., (1996). Intact and impaired memory function in autism Child Development 67: 1816–1835PubMedCrossRefGoogle Scholar
  6. Courchesne E., Karns C. M., Davis H. R., Ziccardi R., Carper R. A., Tigue Z. D., Chisum H. J., Moses P., Pierce K., Lord C., Lincoln A. J., Pizzo S., Schreibman L., Haas R. H., Akshoomoff N. A., Courchesne R. Y., (2001). Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study Neurology 57: 245–254PubMedGoogle Scholar
  7. Frith U., (1989). Autism: Explaining the enigma. Oxford: BlackwellGoogle Scholar
  8. Frith U., Happé F., (1994). Autism: Beyond ‘theory of mind’Cognition 50: 115–132PubMedCrossRefGoogle Scholar
  9. Goldberg M. C., Lasker A. G., Zee D. S., Garth E., Tien A., Landa R. J., (2002). Deficits in the initiation of eye movements in the absence of a visual target in adolescents with high functioning autism Neuropsychologia 40: 2039–2049PubMedCrossRefGoogle Scholar
  10. Gruber O., von Cramon D. Y., (2003). The functional neuroanatomy of human working memory revisited: Evidence from 3-T fMRI studies using classical domain-specific interference tasks NeuroImage 19: 797–809PubMedCrossRefGoogle Scholar
  11. Heaton R. K., Chelune G., Talley J., Talley J. L., Kay G. G., Curtiss G., (1993). Wisconsin card sorting test manual: Revised and expanded. Odessa FL: Psychological Assessment ResourcesGoogle Scholar
  12. Hermelin B., O’Connor N., (1970). Psychological experiments with autistic children New York: Pergamon PressGoogle Scholar
  13. Hughes C., Russell J., Robbins T. W., (1994). Evidence for executive dysfunction in autism Neuropsychologia 32: 477–492PubMedCrossRefGoogle Scholar
  14. Just M. A., Carpenter P. A., (1992) A capacity theory of comprehension: Individual differences in working memory Psychological Review 99: 122–149PubMedCrossRefGoogle Scholar
  15. Just, M. A., Cherkassky, V. L., Keller, T. A., & Minshew, N. J. (2004). Cortical activation and synchronization during sentence comprehension in high-functioning autism: Evidence of underconnectivity. Brain 127: 1811–1821PubMedCrossRefGoogle Scholar
  16. Kimberg D. Y., Farah M. J., (1993). A unified account of cognitive impairments following frontal lobe damage: The role of working memory in complex, organized behavior Journal of Experimental Psychology, General 122: 411–428CrossRefGoogle Scholar
  17. Kaufman A. S., Kaufman N. L., (1985). Kaufman test of educational achievement Circle Pines, MN: American Guidance ServicesGoogle Scholar
  18. Koczat D. L., Rogers S. J., Pennington B. F., Ross R. G., (2002). Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probandsJournal of Autism and Developmental Disorders 32: 513–519PubMedCrossRefGoogle Scholar
  19. Kojima S., Goldman-Rakic P. S., (1982). Delay-related activity of prefrontal neurons in rhesus monkeys performing delayed response Brain Research 248: 43–50PubMedCrossRefGoogle Scholar
  20. Le Couteur A., Rutter M., Lord C., Rios P., Robertson S., Holdgrafer M., McLennan J., (1989). Autism Diagnostic Interview: A standardized investigator-based instrument Journal of Autism and Developmental Disorders 19: 363–387PubMedCrossRefGoogle Scholar
  21. Levy R., Goldman-Rakic P. S., (2000). Segregation of working memory functions within the dorsolateral prefrontal cortex Experimental Brain Research 133: 23–32CrossRefGoogle Scholar
  22. Lord C., Rutter M., Goode S., Heemsbergen J., Jordan H., Mawhood L., Schopler E., (1989) Autism Diagnostic Observation Schedule: A standardized observation of communicative and social behavior Journal of Autism and Developmental Disorders 19: 185–212PubMedCrossRefGoogle Scholar
  23. Lord C., Rutter M., Le Couteur A., (1994) Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disordersJournal of Autism and Developmental Disorders 24: 659–685PubMedCrossRefGoogle Scholar
  24. Lord C., Rutter M., DiLavore P. C., Risi S., (1999) Autism diagnostic observation schedule (ADOS). Los Angeles: Western Psychological ServicesGoogle Scholar
  25. Luna B., Minshew N. J., Garver K. E., Lazar N. A., Thulborn K. R., Eddy W. F., Sweeney J. A., (2002). Neocortical system abnormalities in autism: An fMRI Study of spatial working memory Neurology 59: 834–840PubMedGoogle Scholar
  26. Minshew N. J., Goldstein G., (2001). The pattern of intact and impaired memory functions in autism Journal of Child Psychology and Psychiatry 42: 1095–1101PubMedCrossRefGoogle Scholar
  27. Minshew N. J., Goldstein G., Siegel D. J. (1995). Speech and language in high-functioning autistic individuals Neuropsychology 9: 255–261CrossRefGoogle Scholar
  28. Minshew N. J., Goldstein G., Siegel D. J., (1997). Neuropsychologic functioning in autism: Profile of a complex information processing disorder Journal of the International Neuropsychological Society 3: 303–316PubMedGoogle Scholar
  29. Minshew N. J., Luna B., Sweeney J. A., (1999). Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism Neurology 52: 917–922PubMedGoogle Scholar
  30. Minshew N. J., Meyer J., Goldstein G., (2002). Abstract reasoning in autism: A dissociation between concept formation and concept identification Neuropsychology 16: 327–334PubMedCrossRefGoogle Scholar
  31. Minshew N. J., Sweeney J. A., Luna B., (2002). Autism as a selective disorder of complex information processing and underdevelopment of neocortical systems Molecular Psychiatry 7: S14–S15PubMedCrossRefGoogle Scholar
  32. Ozonoff S., Jensen J., (1999). Specific executive function profiles in three neurodevelopmental disorders Journal of Autism and Developmental Disorders 29: 171–177PubMedCrossRefGoogle Scholar
  33. Ozonoff S., McEvoy R. E., (1994). A longitudinal study of executive function and theory of mind development in autism Development and Psychopathology 6: 415–431CrossRefGoogle Scholar
  34. Ozonoff S., Pennington B. F., Rogers S. J., (1991). Executive function deficits in high-functioning autistic individuals: Relationship to theory of mind Journal of Child Psychology and Psychiatry 32: 1081–1105PubMedCrossRefGoogle Scholar
  35. Ozonoff S., Strayer D. L., (2001). Further evidence of intact working memory in autism Journal of Autism and Developmental Disorders 31: 257–263PubMedCrossRefGoogle Scholar
  36. Pennington B. F., (1994). The working memory function of the pre-frontal cortices: Implications for developmental and individuals differences in cognition. In: Haith M. M., Benson J. B., Roberts R. J., Pennington B. F., (Eds), The development of future-oriented processes. Chicago: University of Chicago PressGoogle Scholar
  37. Piven J., Arndt S., Bailey J., Havercamp S., Andreasen N. C., Palmer P., (1995). An MRI study of brain size in autism American Journal of Psychiatry 152: 1145–1149PubMedGoogle Scholar
  38. Rumsey J. M., Hamburger S. D., (1988) Neuropsychological findings in high-functioning men with infantile autism, residual state Journal of Clinical and Experimental Neuropsychology 10: 201–221PubMedCrossRefGoogle Scholar
  39. Russell J., Jarrold C., Henry L., (1996). Working memory in children with autism and moderate learning difficulties Journal of Child Psychology and Psychiatry 37: 673–686PubMedCrossRefGoogle Scholar
  40. Shallice T., (1982). Specific impairments in planning. In: Broadbent D. E., Weiskrantz L., (Eds), The neuropsychology of cognitive function. London: Royal Society pp. 199–209Google Scholar
  41. Sheslow D., Adams W., (1990). WRAML: Wide range assessment of memory and learning. Wilmington, DE: Jastak Assessment SystemsGoogle Scholar
  42. Smith E. E., Jonides J., (1999). Storage and executive processes in the frontal lobes Science 283: 1657–1661PubMedCrossRefGoogle Scholar
  43. Smith E. E., Jonides J., (1998). Neuroimaging analyses of human working memory Proceedings of the National Academy of Sciences 95: 12061–12068CrossRefGoogle Scholar
  44. Szatmari P., MacLean J. E., Jones M. B., Bryson S. E., Zwaigenbaum L., Bartolucci G., Mahoney W. J., Tuft L., (2000). The familial aggregation of the lesser variant in biological and nonbiological relatives of PDD probands: A family history study Journal of Child Psychology and Psychiatry 41: 579–586PubMedGoogle Scholar
  45. Wechsler D., (1991). Wechsler intelligence scale for children 3. San Antonio, TX: The Psychological CorporationGoogle Scholar
  46. Wechsler D., (1997a). Wechsler adult intelligence scale 3. San Antonio, TX: The Psychological CorporationGoogle Scholar
  47. Wechsler D., (1997b). Wechsler Memory Scale-III: Administration and scoring manual. San Antonio, TX: The Psychological CorporationGoogle Scholar
  48. Williams, D. L., Goldstein, G., & Minshew, N. J. (2004). A further characterization of complex cognitive abilities in high functioning autism. Manuscript submitted for publicationGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Diane L. Williams
    • 1
  • Gerald Goldstein
    • 2
  • Patricia A. Carpenter
    • 3
  • Nancy J. Minshew
    • 4
    • 5
  1. 1.School of MedicineUniversity of PittsburghPittsburghUSA
  2. 2.VA Pittsburgh Healthcare System, School of MedicineUniversity of PittsburghPittsburghUSA
  3. 3.Carnegie Mellon UniversityPittsburghUSA
  4. 4.School of MedicineUniversity of PittsburghPittsburghUSA
  5. 5.School of MedicineUniversity of PittsburghPittsburghUSA

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