Journal of Autism and Developmental Disorders

, Volume 35, Issue 2, pp 177–182 | Cite as

A Family History Study of Asperger Syndrome

  • Mohammad Ghaziuddin

Asperger syndrome (AS) is a childhood-onset disorder often described as a mild variant of autism. Although classified as a distinct disorder in the DSM-IV, its overlap with autism continues to be a matter of ongoing debate. While the family genetic origins of autism are well established, few studies have investigated this topic in AS using current operational criteria. In this report, we examined the family psychiatric history of 58 subjects with AS diagnosed according to DSM-IV criteria (48 males; mean age 13.34; mean full scale IQ 104.87). All subjects had a history of mild autistic social deficits; focused special interests; normal level of intelligence; and an odd and often pedantic manner of speaking. None had a previous diagnosis of autism. Of the 58 subjects with Asperger syndrome, three had first degree relatives with AS; nine (15%) had a family history of schizophrenia; and 35 (60%) had a family history of depression. Of the 64 siblings, four had a diagnosis of AS and none of autism. Compared with a group of 39 subjects with normal intelligence autism (high functioning autism, HFA; 33 males; mean age 15.34; mean full scale IQ 85.89) subjects with AS were more likely to have relatives with depression; schizophrenia; and the broader autistic phenotype. Possible reasons for and implications of these findings are discussed.


Asperger syndrome autism depression schizophrenia family history genetics 


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  1. American Psychiatric Association1994Diagnostic and statistical manual of mental disorders: Fourth editionAPAWashingtonGoogle Scholar
  2. Asperger, H. 1944Die autistischen Psychopathen im KindersalterArchiv fur Psychiatrie und Nervenkrankheiten11776136Google Scholar
  3. Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., Rutter, M. 1995Autism as a strongly genetic disorder: Evidence from a British twin studyPsychological Medicine256377Google Scholar
  4. Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., Bailey, A., Rutter, M. 1994A case–control family history study of autismJournal of Child Psychology and Psychiatry35877900Google Scholar
  5. Dykens, E., Volkmar, F., Glick, M. 1991Thought disorder in high-functioning autistic adultsJournal of Autism and Developmental Disorders21291301Google Scholar
  6. Ehlers, S., Gillberg, C., Wing, L. 1999A screening questionnaire for Asperger syndrome and other high-functioning autism spectrum disorders in school age childrenJournal of Autism and Developmental Disorders2912941Google Scholar
  7. Fombonne, E., Tidmarsh, L. 2003Epidemiologic data on Asperger disorderChild and Adolescent Psychiatric Clinics of North America121521Google Scholar
  8. Fostein, S., Stangelo, S. L. 2000Does Asperger syndrome aggregate in families? Klin Volkmar Sparrow, A. F. S. S. eds. Asperger syndromeGuliford PressNew YorkGoogle Scholar
  9. Ghaziuddin, M., Tsai, L., Ghaziuddin, N. 1992A comparison of the diagnostic criteria for Asperger syndromeJournal of Autism and Developmental Disorders22643649Google Scholar
  10. Ghaziuddin, N., Metler, L., Ghaziuddin, M., Tsai, L., Giordani, B. 1993Three siblings with Asperger syndrome: A family case studyEuropean Child and Adolescent Psychiatry24449Google Scholar
  11. Ghaziuddin, M., Leininger, L, Tsai, L. 1995Thought disorder in Asperger syndrome: Comparison with high-functioning autismJournal of Autism and Developmental Disorders25311317Google Scholar
  12. Gillberg, C. 1989Asperger syndrome in 23 Swedish childrenDevelopmental Medicine and Child Neurology31520531Google Scholar
  13. Gillberg, C. 1998Asperger syndrome and high-functioning autismBritish Journal of Psychiatry172200209Google Scholar
  14. Kendler, K. S., McGuire, M., Gruenberg, A. M., O’Hare, A., Spellman, M., Walsh, D. 1993The Roscommon family study: III Schizophrenia-related personality disorders in relatives Archives of General Psychiatry50781788Google Scholar
  15. Krug, D. A., Arick, J., Almond, P. 1980Behavior checklist for identifying severely handicapped individuals with high levels of autistic behaviorJournal of Child Psychology and Psychiatry21221229Google Scholar
  16. Lord, C., Rutter, M., Couteur, A. 1994Autism diagnostic interview – revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disordersJournal of Autism and Developmental Disorders24659685Google Scholar
  17. McKenna, K., Gordon, C. T., Lenane, M., Kaysen, D., Fahey, K., Rapoport, J. L. 1994Looking for childhood-onset schizophrenia: the first 71 cases screenedJournal of the American Academy of Child and Adolescent Psychiatry3363644Google Scholar
  18. Miller, J. N., Ozonoff, S. 1997Did Asperger’s cases have Asperger disorder? A research noteJournal of Child Psychology and Psychiatry38247251Google Scholar
  19. Parnas, J., Cannon, T. D., Jacobsen, B., Schulsinger, H., Schulsinger, F., Mednick, S. A. 1993Lifetime DSM-III-R diagnostic outcomes in the offspring of schizophrenic mothers: Results from the Copenhagen high-risk studyArchives of General Psychiatry50707714Google Scholar
  20. Petty, L. K., Ornitz, E. M., Michelman, J. D., Zimmerman, E. G. 1984Autistic children who become schizophrenicArchives of General Psychiatry4112935Google Scholar
  21. Piven, J., Chase, G. A., Landa, R., Wzorek, M., Gayle, J., Cloud, D., Folstein, S. 1991Psychiatric disorders in the parents of autistic individualsJournal of the American Academy of Child and Adolescent Psychiatry30471478Google Scholar
  22. Piven, J., Wzorek, M., Landa, R., Lainhart, J., Bolton, P., Chase, G. A., Folstein, S. 1994Personality characteristics of the parents of autistic individualsPsychological Medicine24783795Google Scholar
  23. Rutter, M. 1972Childhood schizophrenia reconsideredJournal of Autism and Childhood Schizophrenia2315337Google Scholar
  24. Spiker, D., Lotspeich, L. J., Dimiceli, S., Myers, R. M., Risch,  2002Behavioral phenotypic variation in autism multiplex families: Evidence for a continuous severity gradientAmerican Journal of Medical Genetics (Neuropsychiatric Genetics)114129136Google Scholar
  25. Stahlberg, O., Soderstrom, H., Rastam, M., Gillberg, C. 2004Bipolar disorder, schizophrenia, and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disordersJournal of Neural Transmission111891902Google Scholar
  26. Krevelen, D. A. 1971Early infantile autism and autistic psychopathyJournal of Autism and Childhood Schizophrenia18286Google Scholar
  27. Volkmar, F., Klin, A., Schultz, R., Bronen, R., Marans, W. D., Sparrow, S., Cohen, D. J. 1996Asperger’s SyndromeJournal of the American Academy of Child and Adolescent Psychiatry351181123Google Scholar
  28. Wing, L. 1981Asperger’s syndrome: A clinical accountPsychological Medicine11115129Google Scholar
  29. Wolff, S., Chick, J. 1980Schizoid personality in childhood: A controlled follow-up studyPsychological Medicine1085100Google Scholar
  30. Ylisaukko-oja, T., Nieminen-von Wendt, T., Kempas, E., Sarenius, S., Varilo, T., Wendt, L., Peltonen, L., Jarvela, I. 2004Genome-wide scan for loci of Asperger syndromeMolecular Psychiatry9161168Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Mohammad Ghaziuddin
    • 1
  1. 1.Division of Child PsychiatryUniversity of Michigan Medical CenterAnn ArborUSA

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