Abstract
Competing hypotheses for explaining the role of anxiety in the relation between attention-deficit/hyperactivity disorder (ADHD) symptoms and childhood aggression were evaluated. Two studies tested whether anxiety exacerbated, attenuated, or had no effect on the relation between ADHD and aggression subtypes among psychiatrically hospitalized children. In Study 1 (N = 99), children who scored above clinical cut-off levels for anxiety only, ADHD only, and co-occurring ADHD and anxiety were compared on aggression subtypes (i.e., reactive, proactive, overt, and relational aggression). In Study 2, the moderating role of anxiety on the relation between ADHD and aggression subtypes was examined with a larger sample (N = 265) and with continuous variables. No support was found for either the attenuation or exacerbation hypothesis, and results remained consistent when separately examining hyperactivity/impulsivity and inattention symptoms of ADHD. Although ADHD symptoms were significantly associated with all aggression subtypes, this association did not remain when including symptoms of oppositional defiant disorder.
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Notes
Although unavailable for the full sample, parent-reported DSM-IV diagnoses were available for 79 of the children using the Diagnostic Interview Schedule for Children (DISC-IV). Of particular interest given the use of psychiatrically hospitalized children in the present studies is the potential for elevated rates of bipolar disorder and posttraumatic stress disorder (PTSD) that may cloud our examination of ADHD and anxiety given symptom overlap. Among the children for whom DISC diagnoses were available, few met criteria for either mania or PTSD. Specifically, 1 child met criteria for mania and 6 children met criteria for PTSD. These children were retained in the study analyses since DISC diagnoses were not available for the full sample and thus could not be used consistently as an exclusionary criterion across all participating children.
When ADHD-Inattentive and ADHD-Hyperactive/Impulsive symptoms were examined simultaneously, ADHD-Hyperactive/Impulsive symptoms significantly predicted all aggression outcomes above and beyond ADHD-Inattentive symptoms. ADHD-Inattentive symptoms no longer predicted any aggression outcome above and beyond ADHD-Hyperactive/Impulsive symptoms.
References
Abikoff, H. B., Jensen, P. S., Arnold, L. L. E., Hoza, B., Hechtman, L., Pollack, S., et al. (2002). Observed classroom behavior of children with ADHD: relationship to gender and comorbidity. Journal of Abnormal Child Psychology, 30, 349–359. doi:10.1023/A:1015713807297.
Achenbach, T. M. (2001). Child behavior checklist for ages 6 to 18. Burlington: University of Vermont, Research Center for Children, Youth, and Families.
Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA school-age forms and profiles. Burlington: University of Vermont, Research Center for Children, Youth, and Families.
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision). Washington, DC: Author.
Angold, A., Costello, E. J., & Erkanli, A. (1999). Comorbidity. Journal of Child Psychology and Psychiatry, 40, 57–87. doi:10.1111/1469-7610.00424.
Applegate, B., Lahey, B. B., Hart, E. L., Biederman, J., Hynd, G. W., Barkley, R. A., et al. (1997). Validity of the age-of-onset criterion for ADHD: a report from the DSM-IV field trials. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 1211–1221. doi:10.1097/00004583-199709000-00013.
Askénazy, F. L., Sorci, K., Benoit, M., Lestideau, K., Myquel, M., & Lecrubier, Y. (2003). Anxiety and impulsivity levels identify relevant subtypes in adolescents with at-risk behavior. Journal of Affective Disorders, 74, 219–227. doi:10.1016/S0165-0327(02)00455-X.
Baldwin, J. S., & Dadds, M. R. (2008). Examining alternative explanations of the covariation of ADHD and anxiety symptoms in children: a community study. Journal of Abnormal Child Psychology, 36, 67–79. doi:10.1007/s10802-007-9160-1.
Becker, S. P., & Kerig, P. K. (2011). Posttraumatic stress symptoms are associated with the frequency and severity of delinquency among detained boys. Journal of Clinical Child and Adolescent Psychology, 40, 765–771. doi:10.1080/15374416.2011.597091.
Bennett, D. S., Pitale, M., Vora, V., & Rheingold, A. A. (2004). Reactive vs. proactive antisocial behavior: differential correlates of child ADHD symptoms? Journal of Attention Disorders, 7, 197–204. doi:10.1177/108705470400700402.
Biederman, J., Newcorn, J., & Sprich, S. (1991). Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. American Journal of Psychiatry, 148, 564–577.
Biederman, J., Faraone, S. V., Doyle, A., Lehman, B. K., Kraus, I., Perrin, J., et al. (1993). Convergence of the Child Behavior Checklist with structured interview-based psychiatric diagnoses of ADHD children with and without comorbidity. Journal of Child Psychology and Psychiatry, 34, 1241–1251. doi:10.1111/j.1469-7610.1993.tb01785.x.
Blachman, D. R., & Hinshaw, S. P. (2002). Patterns of friendship among girls with and without attention-deficit/hyperactivity disorder. Journal of Abnormal Child Psychology, 30, 625–640. doi:10.1023/A:1020815814973.
Boxer, P. (2007). Aggression in very high-risk youth: examining developmental risk in an inpatient psychiatric population. American Journal of Orthopsychiatry, 77, 636–646. doi:10.1037/0002-9432.77.4.636.
Bubier, J. L., & Drabick, D. A. G. (2009). Co-occurring anxiety and disruptive behavior disorders: the roles of anxious symptoms, reactive aggression, and shared risk processes. Clinical Psychology Review, 29, 658–669. doi:10.1016/j.cpr.2009.08.005.
Burke, J. D., Loeber, R., Lahey, B. B., & Rathouz, P. J. (2005). Developmental transitions among affective and behavioral disorders in adolescent boys. Journal of Child Psychology and Psychiatry, 46, 1200–1210. doi:10.1111/j.1469-7610.2005.00422.x.
Card, N. A., & Little, T. D. (2006). Proactive and reactive aggression in childhood and adolescence: a meta-analysis of differential relations with psychosocial adjustment. International Journal of Behavioral Development, 30, 466–480. doi:10.1177/0165025406071904.
Card, N. A., Stucky, B. D., Sawalani, G. M., & Little, T. D. (2008). Direct and indirect aggression during childhood and adolescence: a meta-analytic review of gender differences, intercorrelations, and relations to maladjustment. Child Development, 79, 1185–1229. doi:10.1111/j.1467-8624.2008.01184.x.
Carlson, C. L., Tamm, L., & Gaub, M. (1997). Gender differences in children with ADHD, ODD, and co-occurring ADHD/ODD identified in a school population. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 1706–1714. doi:10.1097/00004583-199712000-00019.
Cohen, J., Cohen, P., West, S. G., & Aiken, L. S. (2002). Applied multiple regression/correlation analysis for the behavioral sciences (3rd ed.). London: Routledge Academic.
Connor, D. F., & McLaughlin, T. J. (2006). Aggression and diagnosis in psychiatrically referred children. Child Psychiatry and Human Development, 37, 1–14. doi:10.1007/s10578-006-0015-8.
Connor, D. F., Edwards, G., Fletcher, K. E., Baird, J., Barkley, R. A., & Steingard, R. J. (2003). Correlates of comorbid psychopathology in children with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 193–200. doi:10.1097/00004583-200302000-00013.
Connor, D. F., Doerfler, L. A., Toscano, P. F., Volungis, A. M., & Steingard, R. J. (2004). Characteristics of children and adolescents admitted to a residential treatment center. Journal of Child and Family Studies, 13, 497–510. doi:10.1023/B:JCFS.0000044730.66750.57.
Connor, D. F., Chartier, K. G., Preen, E. C., & Kaplan, R. F. (2010). Impulsive aggression in attention-deficit/hyperactivity disorder: symptom severity, co-morbidity, and attention-deficit/hyperactivity disorder subtype. Journal of Child and Adolescent Psychopharmacology, 20, 119–126. doi:10.1089/cap.2009.0076.
Costello, E. J., Mustillo, S., Erkanli, A., Keeler, G., & Angold, A. (2003). Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of General Psychiatry, 60, 837–844.
Cunningham, C. E., & Boyle, M. H. (2002). Preschoolers at risk for attention-deficit hyperactivity disorder and oppositional defiant disorder: family, parenting, and behavioral correlates. Journal of Abnormal Child Psychology, 30, 555–569. doi:10.1023/A:1020855429085.
Cunningham, N. R., & Ollendick, T. H. (2010). Comorbidity of anxiety and conduct problems in children: implications for clinical research and practice. Clinical Child and Family Psychology Review, 13, 333–347. doi:10.1007/s10567-010-0077-9.
Deming, A. M., & Lochman, J. E. (2008). The relation of locus of control, anger, and impulsivity to boys’ aggressive behavior. Behavioral Disorders, 33, 108–119.
Dodge, K. A., & Coie, J. D. (1987). Social-information-processing factors in reactive and proactive aggression in children’s peer groups. Journal of Personality and Social Psychology, 53, 1146–1158. doi:10.1037/0022-3514.53.6.1146.
Dodge, K. A., Lochman, J. E., Harnish, J. D., Bates, J. E., & Pettit, G. S. (1997). Reactive and proactive aggression in school children and psychiatrically impaired chronically assaultive youth. Journal of Abnormal Psychology, 106, 37–51. doi:10.1037/0021-843X.106.1.37.
Drabick, A. G., Ollendick, T. H., & Bubier, J. L. (2010). Co-occurrence of ODD and anxiety: shared risk processes and evidence for a dual-pathway model. Clinical Psychology: Science and Practice, 17, 307–318. doi:10.1111/j.1468-2850.2010.01222.x.
Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2010). Classification of behavior disorders in adolescence: scaling methods, predictive validity, and gender differences. Journal of Abnormal Psychology, 119, 699–712. doi:10.1037/a0018610.
Fite, P. J., Stauffacher, K., Ostrov, J. M., & Colder, C. R. (2008). Replication and extension of Little et al.’s (2003) forms and functions of aggression measure. International Journal of Behavioral Development, 32, 238–242. doi:10.1177/0165025408089273.
Ford, T., Goodman, R., & Meltzer, H. (2003). The British child and adolescent mental health survey 1999: the prevalence of DSM-IV disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 1203–1211. doi:10.1097/00004583-200310000-00011.
Frick, P. J., Lilienfeld, S. O., Ellis, M., Loney, B., & Silverthorn, P. (1999). The association between anxiety and psychopathy dimensions in children. Journal of Abnormal Child Psychology, 27, 383–392. doi:10.1023/A:1021928018403.
Gadow, K. D., & Nolan, E. E. (2002). Differences between preschool children with ODD, ADHD, and ODD+ADHD symptoms. Journal of Child Psychology and Psychiatry, 43, 191–201. doi:10.1111/1469-7610.00012.
Gaub, M., & Carlson, C. L. (1997). Gender differences in ADHD: a meta-analysis and critical review. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 1036–1045. doi:10.1097/00004583-199708000-00011.
Goren, S., Singh, N. N., & Best, A. M. (1993). The aggression-coercion cycle: use of seclusion and restraint in a child psychiatric hospital. Journal of Child and Family Studies, 2, 61–73. doi:10.1007/BF01321301.
Gray, J. A. (1987). The psychology of fear and stress (2nd ed.). Cambridge: Cambridge University Press.
Harty, S. C., Miller, C. J., Newcorn, J. H., & Halperin, J. M. (2009). Adolescents with childhood ADHD and comorbid disruptive behavior disorders: aggression, anger, and hostility. Child Psychiatry and Human Development, 40, 85–97. doi:10.1007/s10578-008-0110-0.
Hinshaw, S. P. (1987). On the distinction between attentional deficits/hyperactivity and conduct problems/aggression in child psychopathology. Psychological Bulletin, 101, 443–463. doi:10.1037/0033-2909.101.3.443.
Ialongo, N., Edelsohn, G., Werthamer-Larsson, L., Crockett, L., & Kellam, S. (1996). The course of aggression in first-grade children with and without comorbid anxious symptoms. Journal of Abnormal Child Psychology, 24, 445–456. doi:10.1007/BF01441567.
Jarrett, M. A., & Ollendick, T. H. (2008). A conceptual review of the comorbidity of attention-deficit/hyperactivity disorder and anxiety: implications for future research and practice. Clinical Psychology Review, 28, 1266–1280. doi:10.1016/j.cpr.2008.05.004.
Jensen, P. S., Watanabe, H. K., Richters, J. E., Roper, M., Hibbs, E. D., Salzberg, A. D., et al. (1996). Scales, diagnoses, and child psychopathology: II. Comparing the CBCL and the DISC against external validators. Journal of Abnormal Child Psychology, 24, 151–168. doi:10.1007/BF01441482.
Jensen, P., Hinshaw, S., Kraemer, H., Lenora, N., Newcorn, J., Abikoff, H., et al. (2001). ADHD comorbidity findings from the MTA study: comparing comorbid subgroups. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 147–158. doi:10.1097/00004583-200102000-00009.
Kendall, P. C., Brady, E. U., & Verduin, T. L. (2001). Comorbidity in childhood anxiety disorders and treatment outcomes. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 787–794. doi:10.1097/00004583-200107000-00013.
Kendall, P. C., Puliafico, A. C., Barmish, A. J., Choudhury, M. S., Henin, A., & Treadwall, K. S. (2007). Assessing anxiety with the child behavior checklist and the teacher report form. Journal of Anxiety Disorders, 21, 1004–1015. doi:10.1016/j.janxdis.2006.10.012.
Kerr, M., Tremblay, R. E., Pagani, L., & Vitaro, F. (1997). Boys’ behavioral inhibition and the risk of later delinquency. Archives of General Psychiatry, 54, 809–816.
Kovacs, M., & Devlin, B. (1998). Internalizing disorders in childhood. Journal of Child Psychology and Psychiatry, 39, 47–63. doi:10.1111/1469-7610.00303.
Lahey, B. B., Waldman, I. D., & McBurnett, K. (1999). Annotation: the development of antisocial behavior: an integrative causal model. Journal of Child Psychology and Psychiatry, 40, 669–682. doi:10.1111/1469-7610.00484.
Levy, K., Hunt, C., & Heriot, S. (2007). Treating comorbid anxiety and aggression in children. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 1111–1118. doi:10.1097/chi.0b013e318074eb32.
Lilienfeld, S. O. (2003). Comorbidity between and within childhood externalizing and internalizing disorders: reflections and directions. Journal of Abnormal Child Psychology, 31, 285–291. doi:10.1023/A:1023229529866.
Little, T. D., Jones, S. M., Henrich, C. C., & Hawley, P. H. (2003). Disentangling the “whys” from the “whats” of aggressive behaviour. International Journal of Behavioral Development, 27, 122–133. doi:10.1080/01650250244000128.
Luebbe, A. M., Bell, D., Allwood, M., Swenson, L., & Early, M. (2010). Social information processing in children: specific relations to anxiety, depression, and affect. Journal of Clinical Child and Adolescent Psychology, 39, 386–399. doi:10.1080/15374411003691685.
Maedgen, J. W., & Carlson, C. L. (2000). Social functioning and emotional regulation in the attention deficit hyperactivity disorder subtypes. Journal of Clinical Child Psychology, 29, 30–42. doi:10.1207/S15374424jccp2901_4.
March, J. S., Swanson, J. M., Arnold, L. E., Hoza, B., Conners, C. K., Hinshaw, S. P., et al. (2000). Anxiety as a predictor and outcome variable in the Multimodal Treatment Study of Children with ADHD (MTA). Journal of Abnormal Child Psychology, 28, 527–541. doi:10.1023/A:1005179014321.
Merikangas, K. R., He, J., Burstein, M., Swanson, S. A., Aveneoli, S., Cui, L., et al. (2010). Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication-Adolescent Supplement (NCS-A). Journal of the American Academy of Child and Adolescent Psychiatry, 49, 980–989. doi:10.1016/j.jaac.2010.05.017.
Mikami, A. Y., & Lorenzi, J. (2011). Gender and conduct problems predict peer functioning among children with attention-deficit/hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 40, 777–786. doi:10.1080/15374416.2011.597089.
Mikami, A. Y., Ransone, M. L., & Calhoun, C. D. (2011). Influence of anxiety on the social functioning of children with and without ADHD. Journal of Attention Disorders, 15, 473–484. doi:10.1177/1087054710369066.
Murray-Close, D., Ostrov, J. M., & Crick, N. R. (2007). A short-term longitudinal study of growth of relational aggression during middle childhood: associations with gender, friendship intimacy, and internalizing problems. Development and Psychopathology, 19, 187–203. doi:10.1017/S0954579407070101.
Nakamura, B. J., Ebesutani, C., Bernstein, A., & Chorpita, B. F. (2009). A psychometric analysis of the Child Behavior Checklist DSM-oriented scales. Journal of Psychopathology and Behavioral Assessment, 31, 178–189. doi:10.1007/s10862-008-9119-8.
Newcorn, J. H., Halperin, J. M., Jensen, P. S., Abikoff, H. B., Arnold, L. E., Cantwell, D. P., et al. (2001). Symptom profiles in children with ADHD: effects of comorbidity and gender. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 137–146. doi:10.1097/00004583-200102000-00008.
Nigg, J. T., Goldsmith, H. H., & Sachek, J. (2004). Temperament and attention deficit hyperactivity disorder: the development of a multiple pathway model. Journal of Clinical Child and Adolescent Psychology, 33, 42–53. doi:10.1207/S15374424JCCP3301_5.
O’Brien, B. S., & Frick, P. J. (1996). Reward dominance: associations with anxiety, conduct problems, and psychopathy in children. Journal of Abnormal Child Psychology, 24, 223–240. doi:10.1007/BF01441486.
Pardini, D. A., & Fite, P. J. (2010). Symptoms of conduct disorder, oppositional defiant disorder, attention-deficit/hyperactivity disorder, and callous-unemotional traits as unique predictors of psychosocial maladjustment in boys: Advancing an evidence base for DSM-V. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 1134–1144. doi:10.1016/j.jaac.2010.07.010.
Perrin, S., & Last, C. G. (1996). Relationship between ADHD and anxiety in boys: results from a family study. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 988–996. doi:10.1097/00004583-199608000-00009.
Pliszka, S. R. (1989). Effect of anxiety on cognition, behavior, and stimulant response in ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 882–887. doi:10.1097/00004583-198911000-00012.
Power, T. J., Costigan, T. E., Eiraldi, R. B., & Leff, S. S. (2004). Variations in anxiety and depression as a function of ADHD subtypes defined by DSM-IV: Do subtype differences exist or not? Journal of Abnormal Child Psychology, 32, 27–37. doi:10.1023/B:JACP.0000007578.30863.93.
Quay, H. C. (1988). The behavioral reward and inhibition system in childhood behavior disorders. In L. M. Bloomingdale (Ed.), Attention deficit disorder (Vol. 3, pp. 176–186). New York: Pergamon.
Raine, A., Dodge, K., Loeber, R., Gatzke-Kopp, L., Lynam, D., Reynolds, C., et al. (2006). The reactive-proactive aggression questionnaire: differential correlates of reactive and proactive aggression in adolescent boys. Aggressive Behavior, 32, 159–171. doi:10.1002/ab.20115.
Sørensen, L., Plessen, K. J., Nicholas, J., & Lundervold, A. J. (2011). Is behavioral regulation in children with ADHD aggravated by comorbid anxiety disorder? Journal of Attention Disorders, 15, 56–66. doi:10.1177/1087054709356931.
Tremblay, R. E., Pihl, R. O., Vitaro, F., & Dobkin, P. L. (1994). Predicting early onset on male antisocial behavior from preschool behavior. Archives of General Psychiatry, 51, 732–739. doi:10.1001/archpsyc.1994.03950090064009.
Vitaro, F., Brendgen, M., & Tremblay, R. E. (2002). Reactively and proactively aggressive children: antecedent and subsequent characteristics. Journal of Child Psychology and Psychiatry, 43, 495–505. doi:10.1111/1469-7610.00040.
Walton, K. E., Ormel, J., & Krueger, R. F. (2011). The dimensional nature of externalizing behaviors in adolescence: evidence from a direct comparison of categorical, dimensional, and hybrid models. Journal of Abnormal Child Psychology, 39, 553–561. doi:10.1007/s10802-010-9478-y.
Waschbusch, D. A., & Willoughby, M. T. (2008). Attention-deficit/hyperactivity disorder and callous-unemotional traits as moderators of conduct problems when examining impairment and aggression in elementary school children. Aggressive Behavior, 34, 139–153. doi:10.1002/ab.20224.
Waschbusch, D. A., Willoughby, M. T., & Pelham, W. E., Jr. (1998). Criterion validity and the utility of reactive and proactive aggression: comparisons to attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, and other measures of functioning. Journal of Clinical Child Psychology, 27, 396–405. doi:10.1207/s15374424jccp2704_3.
Wilens, T. E., Biederman, J., & Spencer, T. J. (2002). Attention-deficit/hyperactivity disorder across the lifespan. Annual Review of Medicine, 53, 113–131. doi:10.1146/annurev.med.53.082901.103945.
Zalecki, C. A., & Hinshaw, S. P. (2004). Overt and relational aggression in girls with attention deficit hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 33, 125–137. doi:10.1207/S15374424JCCP3301_12.
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Portions of this paper were presented at the 83rd Annual Meeting of the Midwestern Psychological Association, Chicago, Illinois (May, 2011). The authors thank the families who participated in these studies, as well as comments by Joshua Langberg on an earlier draft of this article.
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Becker, S.P., Luebbe, A.M., Stoppelbein, L. et al. Aggression Among Children with ADHD, Anxiety, or Co-occurring Symptoms: Competing Exacerbation and Attenuation Hypotheses. J Abnorm Child Psychol 40, 527–542 (2012). https://doi.org/10.1007/s10802-011-9590-7
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DOI: https://doi.org/10.1007/s10802-011-9590-7