A Longitudinal Twin Study on the Association Between Inattentive and Hyperactive-Impulsive ADHD Symptoms
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DSM-IV distinguishes two symptom domains of attention deficit hyperactivity disorder (ADHD): inattentiveness and hyperactivity-impulsivity. The present study examines the aetiologies and developmental relations underlying the associations between inattentiveness and hyperactivity-impulsivity over time, based on a representative population sample from the United Kingdom of approximately 7,000 twin pairs. ADHD symptoms were assessed as continuous dimensions using the DSM-IV items from the Conners’ Parent Rating Scale at two ages: middle childhood (age 1) and early adolescence (age 2). Quantitative genetic cross-lagged analyses showed that the association of the ADHD dimensions over time is influenced by stable as well as newly developing genetic factors. Moreover the longitudinal relationship between the ADHD dimensions appears to be unidirectional, with hyperactivity-impulsivity in middle childhood predicting the presence of inattentiveness in early adolescence, but not vice versa. Thus, hyperactivity-impulsivity may serve to exacerbate inattentiveness over time. Findings are discussed in the context of developmental changes in ADHD symptoms.
KeywordsADHD Inattentiveness Hyperactivity-impulsivity Longitudinal Genetics
Study supported by the United Kingdom Medical Research Council (G0500079). We are grateful to Twins Early Development Study families.
Conflict of Interest
Asherson has acted in an advisory capacity to Shire, Janssen-Cilag, Eli-Lilly and Flynn Pharma. He is the holder of an educational grant from Janssen-Cilag and a research grant from Shire. He has given talks at meetings or educational program sponsored by to Shire, Janssen-Cilag, Eli-Lilly and Flynn Pharma. The other authors have no competing interests to disclose.
- American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: Author.Google Scholar
- Burns, G. L., Walsh, J. A., Patterson, D. R., Holte, C. S., Sommers-Flanagan, R., & Parker, C. M. (1997). Internal validity of the disruptive behavior disorder symptoms: implications from parent ratings for a dimensional approach to symptom validity. Journal of Abnormal Child Psychology, 25, 307–319.PubMedCrossRefGoogle Scholar
- Chen, W., Zhou, K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., et al. (2008). DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B, 1450–1460.CrossRefGoogle Scholar
- Larsson, J., Larsson, H., & Lichtenstein, P. (2004). Genetic and environmental contributions to stability and change of ADHD symptoms between 8 and 13 year of age: a longitudinal twin study. Journal of the American Academy of Child and Adolescent Psychiatry, 43, 1267–1275.PubMedCrossRefGoogle Scholar
- Larsson, H., Viding, E., Rijsdijk, F. V., & Plomin, R. (2008). Relationships between parental negativity and childhood antisocial behavior over time: a bidirectional effects model in a longitudinal genetically informative design. Journal of Abnormal Child Psycholology, 36, 633–645.CrossRefGoogle Scholar
- Larsson, H., Dilshad, R., Lichtenstein, P., & Barker, E. D. (in press). Developmental trajectories of DSM-IV symptoms of attention-deficit/hyperactivity disorder: genetic effects, family risk and associated psychopathology. Journal of Child Psychology and Psychiatry. doi: 10.1111/j.1469-7610.2011.02379.x
- Luo, Y. L., Haworth, C. M., & Plomin, R. (2010). A novel approach to genetic and environmental analysis of cross-lagged associations over time: the cross-lagged relationship between self-perceived abilities and school achievement is mediated by genes as well as the environment. Twin Research and Human Genetics, 13, 426–436.PubMedCrossRefGoogle Scholar
- McLoughlin, G., Ronald, A., Kuntsi, J., Asherson, P., & Plomin, R. (2007). Genetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive components. Journal of Abnormal Child Psychology, 35, 999–1008.PubMedCrossRefGoogle Scholar
- Nadder, T. S., Rutter, M., Silberg, J. L., Maes, H. H., & Eaves, L. J. (2002). Genetic effects on the variation and covariation of attention deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (Odd/CD) symptomatologies across informant and occasion of measurement. Psychological Medicine, 32, 39–53.PubMedCrossRefGoogle Scholar
- Neale, M. C., Boker, S. M., Xie, G., & Maes, H. (2006). Mx: Statistical modeling (7th ed.). Richmond: Department of Psychiatry, Medical College of Virginia.Google Scholar
- Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2008). Behavioral genetics (5th ed.). New York: Worth Publishers.Google Scholar
- Todd, R. D., Huang, H., Todorov, A. A., Neuman, R. J., Reiersen, A. M., Henderson, C. A., et al. (2008). Predictors of stability of attention-deficit/hyperactivity disorder subtypes from childhood to young adulthood. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 76–85.PubMedCrossRefGoogle Scholar