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Journal of Abnormal Child Psychology

, Volume 38, Issue 7, pp 921–934 | Cite as

Alternative Factor Models and Heritability of the Short Leyton Obsessional Inventory—Children’s Version

  • Janette MooreEmail author
  • Gillian W. Smith
  • Mark Shevlin
  • Francis A. O’Neill
Article

Abstract

An alternative models framework was used to test three confirmatory factor analytic models for the Short Leyton Obsessional Inventory-Children’s Version (Short LOI-CV) in a general population sample of 517 young adolescent twins (11–16 years). A one-factor model as implicit in current classification systems of Obsessive–Compulsive Disorder (OCD), a two-factor obsessions and compulsions model, and a multidimensional model corresponding to the three proposed subscales of the Short LOI-CV (labelled Obsessions/Incompleteness, Numbers/Luck and Cleanliness) were considered. The three-factor model was the only model to provide an adequate explanation of the data. Twin analyses suggested significant quantitative sex differences in heritability for both the Obsessions/Incompleteness and Numbers/Luck dimensions with these being significantly heritable in males only (heritability of 60% and 65% respectively). The correlation between the additive genetic effects for these two dimensions in males was 0.95 suggesting they largely share the same genetic risk factors.

Keywords

Obsessive-compulsive Confirmatory factor analysis Heritability Adolescents Twins 

Notes

Acknowledgment

The authors would like to thank those who participated in the study and staff of the Eastern, Western and Southern Health and Social Services Boards, Homefirst Community Trust and the Causeway Health and Social Services Trust who facilitated access to the Child Health System Database.

References

  1. Akaike, H. (1974). A new look at the statistical model identification. IEEE Transactions on Automatic Control, 19, 716–723.CrossRefGoogle Scholar
  2. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, D.C.: Author.Google Scholar
  3. Aouizerate, B., Guehl, D., Cuny, E., Rougier, A., Bioulac, B., Tignol, J., et al. (2004). Pathophysiology of obsessive-compulsive disorder: a necessary link between phenomenology, neuropsychology, imagery and physiology. Progress in Neurobiology, 72(3), 195–221.CrossRefPubMedGoogle Scholar
  4. Bamber, D., Tamplin, A., Park, R. J., Kyte, Z. A., & Goodyer, I. M. (2002). Development of a short leyton obsessional inventory for children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 41(10), 1246–1252.CrossRefPubMedGoogle Scholar
  5. Bentler, P. M. (1990). Comparative fit indices in structural models. Psychological Bulletin, 107, 238–246.CrossRefPubMedGoogle Scholar
  6. Bentler, P. M., & Chou, C. (1987). Practical issues in structural modelling. Sociological Methods and Research, 16, 78–117.CrossRefGoogle Scholar
  7. Berg, C. Z., Whitaker, A., Davies, M., Flament, M. F., & Rapoport, J. L. (1988). The survey form of the Leyton Obsessional Inventory-Child Version: norms from an epidemiological study. Journal of the American Academy of Child and Adolescent Psychiatry, 27(6), 759–763.CrossRefPubMedGoogle Scholar
  8. Bloch, M. H., Landeros-Weisenberger, A., Rosario, M. C., Pittenger, C., & Leckman, J. F. (2008). Meta-analysis of the symptom structure of obsessive-compulsive disorder. The American Journal of Psychiatry, 165(12), 1532–1542.CrossRefPubMedGoogle Scholar
  9. Bollen, K. A., & Long, J. S. (1993). Testing structural equation models. Newbury Park: Sage.Google Scholar
  10. Bolton, D., Rijsdijk, F., Eley, T. C., O’Connor, T. G., Briskman, J., & Perrin, S. (2009). Normative childhood repetitive routines and obsessive compulsive symptomatology in 6-year-old twins. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 50(9), 1139–1146.CrossRefPubMedGoogle Scholar
  11. Briggs, S. R., & Cheek, J. M. (1986). The role of factor analysis in the development and evaluation of personality scales. Journal of Personality, 54, 106–148.CrossRefGoogle Scholar
  12. Brown, T. A. (2006). Confirmatory factor analysis for applied research. New York: The Guildford.Google Scholar
  13. Clifford, C. A., Murray, R. M., & Fulker, D. W. (1984). Genetic and environmental influences on obsessional traits and symptoms. Psychological Medicine, 14(4), 791–800.CrossRefPubMedGoogle Scholar
  14. Cooper, J., & Kelleher, M. (1973). The Leyton obsessional inventory: a principal components analysis on normal subjects. Psychological Medicine, 3(2), 204–208.CrossRefPubMedGoogle Scholar
  15. Delorme, R., Bille, A., Betancur, C., Mathieu, F., Chabane, N., Mouren-Simeoni, M. C., et al. (2006). Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a Prospective follow-up study. BMC Psychiatry, 6, 1.CrossRefPubMedGoogle Scholar
  16. Douglass, H. M., Moffitt, T. E., Dar, R., McGee, R., & Silva, P. (1995). Obsessive-compulsive disorder in a birth cohort of 18-year-olds: prevalence and predictors. Journal of the American Academy of Child and Adolescent Psychiatry, 34(11), 1424–1431.CrossRefPubMedGoogle Scholar
  17. Eley, T. C., Bolton, D., O’Connor, T. G., Perrin, S., Smith, P., & Plomin, R. (2003). A twin study of anxiety-related behaviours in pre-school children. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 44(7), 945–960.CrossRefPubMedGoogle Scholar
  18. Flament, M. F., Whitaker, A., Rapoport, J. L., Davies, M., Berg, C. Z., Kalikow, K., et al. (1988). Obsessive compulsive disorder in adolescence: an epidemiological study. Journal of the American Academy of Child and Adolescent Psychiatry, 27(6), 764–771.CrossRefPubMedGoogle Scholar
  19. Flora, D. B., & Curran, P. J. (2004). An empirical evaluation of alternative methods of estimation for confirmatory factor analysis with ordinal data. Psychological Methods, 9(4), 466–491.CrossRefPubMedGoogle Scholar
  20. Foa, E. B., Huppert, J. D., Leiberg, S., Langner, R., Kichic, R., Hajcak, G., et al. (2002). The obsessive-compulsive inventory: development and validation of a short version. Psychological Assessment, 14(4), 485–496.CrossRefPubMedGoogle Scholar
  21. Fontenelle, L. F., Mendlowicz, M. V., & Versiani, M. (2006). The descriptive epidemiology of obsessive-compulsive disorder. Progress in Neuropsychopharmacology and Biological Psychiatry, 30(3), 327–337.CrossRefGoogle Scholar
  22. Frank, E., & Young, E. (2005). Pubertal changes and adolescent challenges: Why do rates of depression rise precipitously for girls between ages 10 and 15 years? In E. Frank (Ed.), Gender and its effects on psychopathology. Washington, DC: American Psychiatric.Google Scholar
  23. Geller, D., Biederman, J., Jones, J., Park, K., Schwartz, S., Shapiro, S., et al. (1998). Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of the pediatric literature. Journal of the American Academy of Child and Adolescent Psychiatry, 37(4), 420–427.CrossRefPubMedGoogle Scholar
  24. Gillespie, N. A., & Martin, N. G. (2005). Multivariate genetic analysis. In B. Everitt & D. Howell (Eds.), Encyclopedia of statistics in behavioral science (Vol. 3, pp. 1363–1370). Chicester: Wiley.Google Scholar
  25. Grados, M. A., & Riddle, M. A. (2008). Two times four is four: OCD dimensions, classes, and categories. Journal of the American Academy of Child and Adolescent Psychiatry, 47(7), 731–733.CrossRefPubMedGoogle Scholar
  26. Hajcak, G., Huppert, J. D., Simons, R. F., & Foa, E. B. (2004). Psychometric properties of the OCI-R in a college sample. Behaviour Research and Therapy, 42(1), 115–123.CrossRefPubMedGoogle Scholar
  27. Hemmings, S. M., & Stein, D. J. (2006). The current status of association studies in obsessive-compulsive disorder. The Psychiatric Clinics of North America, 29(2), 411–444.CrossRefPubMedGoogle Scholar
  28. Heyman, I., Fombonne, E., Simmons, H., Ford, T., Meltzer, H., & Goodman, R. (2001). Prevalence of obsessive-compulsive disorder in the British nationwide survey of child mental health. The British Journal of Psychiatry, 179, 324–329.CrossRefPubMedGoogle Scholar
  29. Horwath, E., & Weissman, M. M. (2000). The epidemiology and cross-national presentation of obsessive-compulsive disorder. The Psychiatric Clinics of North America, 23(3), 493–507.CrossRefPubMedGoogle Scholar
  30. Hu, L., & Bentler, P. M. (1999). Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Structural Equation Modeling, 6, 1–55.CrossRefGoogle Scholar
  31. Hudziak, J. J., Althoff, R. R., Stanger, C., van Beijsterveldt, C. E., Nelson, E. C., Hanna, G. L., et al. (2006). The obsessive compulsive scale of the child behavior checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 47(2), 160–166.CrossRefPubMedGoogle Scholar
  32. Hudziak, J. J., Van Beijsterveldt, C. E., Althoff, R. R., Stanger, C., Rettew, D. C., Nelson, E. C., et al. (2004). Genetic and environmental contributions to the child behavior checklist obsessive-compulsive scale: a cross-cultural twin study. Archives of General Psychiatry, 61(6), 608–616.CrossRefPubMedGoogle Scholar
  33. Huppert, J. D., Walther, M. R., Hajcak, G., Yadin, E., Foa, E. B., Simpson, H. B., et al. (2007). The OCI-R: validation of the subscales in a clinical sample. Journal of Anxiety Disorders, 21(3), 394–406.CrossRefPubMedGoogle Scholar
  34. Hur, Y. M., & Jeong, H. U. (2008). Sex differences in genetic and environmental influences on obsessive-compulsive symptoms in South Korean adolescent and young adult twins. Twin Research and Human Genetics, 11(3), 314–320.CrossRefPubMedGoogle Scholar
  35. Ivarsson, T., & Valderhaug, R. (2006). Symptom patterns in children and adolescents with obsessive-compulsive disorder (OCD). Behaviour Research and Therapy, 44(8), 1105–1116.CrossRefPubMedGoogle Scholar
  36. Janet, P. (1903). Les obsessions et la psychasthenie. Paris: Felix Alcan.Google Scholar
  37. Jonnal, A. H., Gardner, C. O., Prescott, C. A., & Kendler, K. S. (2000). Obsessive and compulsive symptoms in a general population sample of female twins. American Journal of Medical Genetics, 96(6), 791–796.CrossRefPubMedGoogle Scholar
  38. Jöreskorg, K., & Sörbom, D. (1993). Structural equation modelling with the SIMPLIS command language. Chicago: Scientific Software.Google Scholar
  39. Kalra, S. K., & Swedo, S. E. (2009). Children with obsessive-compulsive disorder: are they just “little adults”? The Journal of Clinical Investigation, 119(4), 737–746.CrossRefPubMedGoogle Scholar
  40. Leckman, J. F., Rauch, S. L., & Mataix-Cols, D. (2007). Symptom dimensions in obsessive-compulsive disorder: implications for the DSM-V. CNS Spectrums, 12(5), 376–387. 400.PubMedGoogle Scholar
  41. Leckman, J. F., Zhang, H., Alsobrook, J. P., & Pauls, D. L. (2001). Symptom dimensions in obsessive-compulsive disorder: toward quantitative phenotypes. American Journal of Medical Genetics, 105(1), 28–30.CrossRefPubMedGoogle Scholar
  42. Maggini, C., Ampollini, P., Gariboldi, S., Cella, P. L., Peqlizza, L., & Marchesi, C. (2001). The Parma high school epidemiological survey: obsessive-compulsive symptoms. Acta Psychiatrica Scandinavica, 103(6), 441–446.CrossRefPubMedGoogle Scholar
  43. Mataix-Cols, D. (2006). Deconstructing obsessive-compulsive disorder: a multidimensional perspective. Current Opinion in Psychiatry, 19(1), 84–89.CrossRefPubMedGoogle Scholar
  44. Mataix-Cols, D., Nakatani, E., Micali, N., & Heyman, I. (2008). Structure of obsessive-compulsive symptoms in pediatric OCD. Journal of the American Academy of Child and Adolescent Psychiatry, 47(7), 773–778.CrossRefPubMedGoogle Scholar
  45. Mathews, C. A., Greenwood, T., Wessel, J., Azzam, A., Garrido, H., Chavira, D. A., et al. (2007). Evidence for a heritable unidimensional symptom factor underlying obsessionality. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics.Google Scholar
  46. Miguel, E. C., do Rosario-Campos, M. C., Prado, H. S., do Valle, R., Rauch, S. L., Coffey, B. J., et al. (2000). Sensory phenomena in obsessive-compulsive disorder and Tourette’s disorder. The Journal of Clinical Psychiatry, 61(2), 150–156. quiz 157.PubMedGoogle Scholar
  47. Miguel, E. C., Leckman, J. F., Rauch, S., do Rosario-Campos, M. C., Hounie, A. G., Mercadante, M. T., et al. (2005). Obsessive-compulsive disorder phenotypes: implications for genetic studies. Molecular Psychiatry, 10(3), 258–275.CrossRefPubMedGoogle Scholar
  48. Millet, B., Kochman, F., Gallarda, T., Krebs, M. O., Demonfaucon, F., Barrot, I., et al. (2004). Phenomenological and comorbid features associated in obsessive-compulsive disorder: influence of age of onset. Journal of Affective Disorders, 79(1–3), 241–246.CrossRefPubMedGoogle Scholar
  49. Muthén, L. K., & Muthén, B. O. (1998–2007). Mplus user’s guide. Fifth Edition. Los Angeles: Muthen & Muthen.Google Scholar
  50. Neale, M., & Cardon, L. (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic.Google Scholar
  51. Neale, M. C. (Ed.). (1997). Mx: Statistical modelling (4th edition). Box 126 MCV, Richmond, VA 23298: Department of Psychiatry.Google Scholar
  52. Neale, M. C., & Miller, M. B. (1997). The use of likelihood-based confidence intervals in genetic models. Behavior Genetics, 27, 113–120.CrossRefPubMedGoogle Scholar
  53. Nestadt, G., Di, C. Z., Riddle, M. A., Grados, M. A., Greenberg, B. D., Fyer, A. J., et al. (2009). Obsessive-compulsive disorder: subclassification based on co-morbidity. Psychological Medicine, 39(9), 1491–1501.CrossRefPubMedGoogle Scholar
  54. Noshirvani, H. F., Kasvikis, Y., Marks, I. M., Tsakiris, F., & Monteiro, W. O. (1991). Gender-divergent aetiological factors in obsessive-compulsive disorder. The British Journal of Psychiatry, 158, 260–263.CrossRefPubMedGoogle Scholar
  55. Pallant, J. (2007). SPSS survival manual. Maidenhead: McGraw-Hill.Google Scholar
  56. Phillimore, P., Beattie, A., & Townsend, P. (1994). Widening inequality of health in northern England, 1981–1991. The British Medical Journal, 308, 1125–1128.Google Scholar
  57. Pietrefesa, A. S., & Coles, M. E. (2008). Moving beyond an exclusive focus on harm avoidance in obsessive compulsive disorder: considering the role of incompleteness. Behavior Therapy, 39(3), 224–231.CrossRefPubMedGoogle Scholar
  58. Rapoport, J. L., Inoff-Germain, G., Weissman, M. M., Greenwald, S., Narrow, W. E., Jensen, P. S., et al. (2000). Childhood obsessive-compulsive disorder in the NIMH MECA study: parent versus child identification of cases. Methods for the epidemiology of child and adolescent mental disorders. Journal of Anxiety Disorders, 14(6), 535–548.CrossRefPubMedGoogle Scholar
  59. Rasmussen, S. A., & Eisen, J. L. (1992). The epidemiology and clinical features of obsessive compulsive disorder. The Psychiatric Clinics of North America, 15(4), 743–758.PubMedGoogle Scholar
  60. Rietveld, M. J., van Der Valk, J. C., Bongers, I. L., Stroet, T. M., Slagboom, P. E., & Boomsma, D. I. (2000). Zygosity diagnosis in young twins by parental report. Twin Research, 3(3), 134–141.CrossRefPubMedGoogle Scholar
  61. Rock, D. A., Werts, C. E., & Flaugher, R. L. (1978). The use of analysis of covariance structures for comparing the psychometric properties of multiple variables across populations. Multivariate Behavioral Research, 13, 403–418.CrossRefGoogle Scholar
  62. Rosario-Campos, M. C., Miguel, E. C., Quatrano, S., Chacon, P., Ferrao, Y., Findley, D., et al. (2006). The dimensional Yale-brown obsessive-compulsive scale (DY-BOCS): an instrument for assessing obsessive-compulsive symptom dimensions. Molecular Psychiatry, 11(5), 495–504.CrossRefPubMedGoogle Scholar
  63. Rueda-Jaimes, G. E., Diaz-Martinez, L. A., Escobar-Sanchez, M., Franco-Lopez, J. A., Navarro-Mancilla, A. A., & Cadena-Afanador, L. P. (2007). Validation of the short version of the Leyton obsessional inventory for children and adolescents in Bucaramanga, Colombia. Atencion Primaria, 39(2), 75–80.CrossRefPubMedGoogle Scholar
  64. Sanavio, E. (1988). Obsessions and compulsions: the Padua inventory. Behaviour Research and Therapy, 26(2), 169–177.CrossRefPubMedGoogle Scholar
  65. Scahill, L., Riddle, M. A., McSwiggin-Hardin, M., Ort, S. I., King, R. A., Goodman, W. K., et al. (1997). Children’s Yale-brown obsessive compulsive scale: reliability and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 36(6), 844–852.CrossRefPubMedGoogle Scholar
  66. Skoog, G. (1965). Onset of anancastic conditions. A clinical study. Acta Psychiatrica Scandinavica. Supplementum, 184, 1–82.Google Scholar
  67. Skoog, G., & Skoog, I. (1999). A 40-year follow-up of patients with obsessive-compulsive disorder. Archives of General Psychiatry, 56(2), 121–127.CrossRefPubMedGoogle Scholar
  68. Steiger, J. H., & Lind, J. M. (1980). Statistically based tests for the number of common factors. Iowa City, IA.Google Scholar
  69. Sternberger, L. G., & Burns, G. L. (1990). Obsessions and compulsions: psychometric properties of the Padua Inventory with an American college population. Behaviour Research and Therapy, 28(4), 341–345.CrossRefPubMedGoogle Scholar
  70. Stewart, S. E., Rosario, M. C., Baer, L., Carter, A. S., Brown, T. A., Scharf, J. M., et al. (2008). Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adults. Journal of the American Academy of Child and Adolescent Psychiatry, 47(7), 763–772.CrossRefPubMedGoogle Scholar
  71. Stewart, S. E., Rosario, M. C., Brown, T. A., Carter, A. S., Leckman, J. F., Sukhodolsky, D., et al. (2007). Principal components analysis of obsessive-compulsive disorder symptoms in children and adolescents. Biological Psychiatry, 61(3), 285–291.CrossRefPubMedGoogle Scholar
  72. Storch, E. A., Murphy, T. K., Bagner, D. M., Johns, N. B., Baumeister, A. L., Goodman, W. K., et al. (2006). Reliability and validity of the child behavior checklist obsessive-compulsive scale. Journal of Anxiety Disorders, 20(4), 473–485.CrossRefPubMedGoogle Scholar
  73. Sullivan, P. F., & Eaves, L. J. (2002). Evaluation of analyses of univariate discrete twin data. Behavior Genetics, 32, 221–227.CrossRefPubMedGoogle Scholar
  74. Summerfeldt, L. J. (2004). Understanding and treating incompleteness in obsessive-compulsive disorder. Journal of Clinical Psychology, 60(11), 1155–1168.CrossRefPubMedGoogle Scholar
  75. Summerfeldt, L. J., Richter, M. A., Antony, M. M., & Swinson, R. P. (1999). Symptom structure in obsessive-compulsive disorder: a confirmatory factor-analytic study. Behaviour Research and Therapy, 37(4), 297–311.CrossRefPubMedGoogle Scholar
  76. Tucker, L. R., & Lewis, C. (1973). A reliability coefficient for maximum likelihood factor analysis. Psychometrika, 38, 1–10.CrossRefGoogle Scholar
  77. Uher, R., Heyman, I., Mortimore, C., Frampton, I., & Goodman, R. (2007). Screening young people for obsessive compulsive disorder. The British Journal of Psychiatry, 191, 353–354.CrossRefPubMedGoogle Scholar
  78. van Grootheest, D. S., Bartels, M., van Beijsterveldt, C. E., Cath, D. C., Beekman, A. T., Hudziak, J. J., et al. (2008a). Genetic and environmental contributions to self-report obsessive-compulsive symptoms in Dutch Adolescents at Ages 12, 14, and 16. Journal of the American Academy of Child and Adolescent Psychiatry.Google Scholar
  79. van Grootheest, D. S., Boomsma, D. I., Hettema, J. M., & Kendler, K. S. (2008b). Heritability of obsessive-compulsive symptom dimensions. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 147B(4), 473–478.CrossRefGoogle Scholar
  80. van Grootheest, D. S., Cath, D. C., Beekman, A. T., & Boomsma, D. I. (2007). Genetic and environmental influences on obsessive-compulsive symptoms in adults: a population-based twin-family study. Psychological Medicine, 37(11), 1635–1644.PubMedGoogle Scholar
  81. World Health Organization. (1992). ICD-10 Classification of mental and behavioural disorders-clinical descriptions and diagnostic guidelines. Geneva: World Health Organization.Google Scholar
  82. Zohar, A. H., Ratzoni, G., Pauls, D. L., Apter, A., Bleich, A., Kron, S., et al. (1992). An epidemiological study of obsessive-compulsive disorder and related disorders in Israeli adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 31(6), 1057–1061.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Janette Moore
    • 1
    Email author
  • Gillian W. Smith
    • 2
  • Mark Shevlin
    • 3
  • Francis A. O’Neill
    • 1
  1. 1.Centre for Public Health, Department of PsychiatryQueen’s University of BelfastBelfastUK
  2. 2.Division of PsychologyNottingham Trent UniversityNottinghamUK
  3. 3.School of PsychologyUniversity of UlsterLondonderryUK

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