Journal of Abnormal Child Psychology

, Volume 36, Issue 1, pp 55–65 | Cite as

In the Face of Uncertainty: A Twin Study of Ambiguous Information, Anxiety and Depression in Children

  • Thalia C. Eley
  • Alice M. Gregory
  • Jennifer Y. F. Lau
  • Peter McGuffin
  • Maria Napolitano
  • Fruhling V. Rijsdijk
  • David M. Clark
Article

Abstract

Anxiety and depression share genetic influences, and have been associated with similar cognitive biases. Psychological theories of anxiety and depression highlight threat interpretations of ambiguity. Little is known about whether genes influence cognitive style, or its links to symptoms. We assessed ambiguous word and scenario interpretations, anxiety and depression symptoms in 300 8-year-old twin pairs. There were significant correlations between both negative interpretations of ambiguous words and scenarios and depression symptoms after controlling for anxiety symptoms (r = .13 and .31, respectively), but no significant correlations with anxiety independent of depression. Genetic effects ranged from 16% for depression to 30% for ambiguous word interpretations. Non-shared environmental influences were large (68–70%). Both genetic and environmental influences contributed to the association between depression and ambiguous scenario interpretations. These findings support psychological theories, which emphasise the role of environmental stress both on the development of threat interpretations and on their links with symptoms. The data also support a role for genetic influence on threat interpretations, which may mediate responses to stress.

Keywords

Threat interpretation Ambiguity Anxiety Depression Twins 

Notes

Acknowledgements

The ECHO study is funded by a Medical Research Council Career Development Award to the first author. The preparation of this manuscript was also supported by an ESRC fellowship to the second author. We thank the families who participated in this study, and Georgina Hosang, Fiona Mcleod, Robert Plomin and Jasmine Singh for their input.

References

  1. Alfano, C. A., Beidel, D. C., & Turner, S. M. (2002). Cognition in childhood anxiety: conceptual, methodological, and developmental issues. Clinical Psychology Review, 22, 1209–1238.PubMedGoogle Scholar
  2. Alloy, L. B., Abramson, L. Y., Whitehouse, W. G., Hogan, M. E., Tashman, N. A., Steinberg, D. L. et al. (1999). Depressogenic cognitive styles: predictive validity, information processing and personality characteristics, and developmental origins. Behaviour Research and Therapy, 37, 503–531.PubMedCrossRefGoogle Scholar
  3. Ambrose, B., & Rholes, W. S. (1993). Automatic cognitions and the symptoms of depression and anxiety in children and adolescents: An examination of the content-specificity hypothesis. Cognitive Therapy and Research, 17, 289–308.CrossRefGoogle Scholar
  4. Barrett, P. M., Rapee, R. M., Dadds, M. M., & Ryan, S. M. (1996). Family enhancement of cognitive style in anxious and aggressive children. Journal of Abnormal Child Psychology, 24, 187–203.PubMedCrossRefGoogle Scholar
  5. Beck, A. T. (1967). Depression: Causes and treatment. Philadelphia: Philadelphia University Press.Google Scholar
  6. Beck, A. T., & Clark, D. A. (1988). Anxiety and depression: An information processing perspective. Anxiety Research, 1, 23–36.Google Scholar
  7. Behar, L., & Stringfield, S. (1974). A behavior rating scale for the preschool child. Developmental Psychology, 33, 3–66.Google Scholar
  8. Birmaher, B., Brent, D. A., Chiappetta, L., Bridge, J., Monga, S., & Baugher, M. (1999). Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1230–1236.PubMedCrossRefGoogle Scholar
  9. Bogels, S. M., & Zigterman, D. (2000). Dysfunctional cognitions in children with social phobia, separation anxiety disorder, and generalized anxiety disorder. Journal of Abnormal Child Psychology, 28, 205–211.PubMedCrossRefGoogle Scholar
  10. Butler, G., & Mathews, A. (1983). Cognitive processes in anxiety. Advances in Behaviour Research and Therapy, 5, 51–62.CrossRefGoogle Scholar
  11. Chorpita, B. F., & Barlow, D. H. (1998). The development of anxiety: The role of control in the early environment. Psychological Bulletin, 124, 3–21.PubMedCrossRefGoogle Scholar
  12. Cicchetti, D. (2005). Cognitive and affective neuroscience and developmental psychopathology. Development and Psychopathology, 17, 569–575.PubMedGoogle Scholar
  13. Clark, D. A., Beck, A. T., & Alford, B. A. (1999). Scientific foundations of cognitive theory and therapy of depression. New York, NY: Wiley.Google Scholar
  14. Clark, D. M., Salkovskis, P. M., Ost, L. G., Breitholtz, E., Koehler, K. A., Westling, B. E., et al. (1997). Misinterpretation of body sensations in panic disorder. Journal of Consulting and Clinical Psychology, 65, 203–213.PubMedCrossRefGoogle Scholar
  15. Creswell, C., Schniering, C. A., & Rapee, R. M. (2005). Threat interpretation in anxious children and their mothers: comparison with nonclinical children and the effects of treatment. Behaviour Research and Therapy, 43, 1375–1381.PubMedCrossRefGoogle Scholar
  16. Daleiden, E. L., & Vasey, M. W. (1997). An information-processing perspective on childhood anxiety. Clinical Psychology Review, 17, 407–429.PubMedCrossRefGoogle Scholar
  17. Dineen, K. A., & Hadwin, J. A. (2004). Anxious and depressive symptoms and children’s judgements of their own and others’ interpretation of ambiguous social scenarios. Journal of Anxiety Disorders, 18, 499–513.PubMedCrossRefGoogle Scholar
  18. Elander, J., & Rutter, M. (1996). Use and development of the Rutter parents’ and teachers’ scales. International Journal of Methods in Psychiatric Research, 6, 63–78.CrossRefGoogle Scholar
  19. Eley, T. C., Bolton, D., O’Connor, T. G., Perrin, S., Smith, P., & Plomin, R. (2003). A twin study of anxiety-related behaviours in pre-school children. Journal of Child Psychology and Psychiatry, 44, 945–960.PubMedCrossRefGoogle Scholar
  20. Eley, T. C., & Brown, T. A. (2004). Phenotypic and genetic/environmental structure of anxiety sensitivity in adolescents. Behavior Genetics, 34, 637.Google Scholar
  21. Eley, T. C., & Stevenson, J. (1999a). Exploring the covariation between anxiety and depression symptoms: A genetic analysis of the effects of age and sex. Journal of Child Psychology and Psychiatry, 40, 1273–1284.PubMedCrossRefGoogle Scholar
  22. Eley, T. C., & Stevenson, J. (1999b). Using genetic analyses to clarify the distinction between depressive and anxious symptoms in children and adolescents. Journal of Abnormal Child Psychology, 27, 105–114.PubMedCrossRefGoogle Scholar
  23. French, C., C. & Richards, A. (1992). Word association norms for a set of threat/neutral homographs. Cognition and Emotion, 6, 65–87.CrossRefGoogle Scholar
  24. Fundudis, T., Berney, T. P., Kolvin, I., Famuyiwa, O. O., Barrett, M. L., Bhate, S. R., et al. (1991). Reliability and validity of two self-rating scales in the assessment of childhood depression. British Journal of Psychiatry, 159, 36–40.Google Scholar
  25. Goodman, R., & Scott, S. (1999). Comparing the strengths and difficulties questionnaire and the Child Behavior Checklist: Is small beautiful? Journal of Abnormal Child Psychology, 27, 17–24.PubMedCrossRefGoogle Scholar
  26. Gregory, A. M., Caspi, A., Moffitt, T. E., Koenen, K., Eley, T. C., & Poulton, R. (2007b). Juvenile mental health histories of adults with anxiety disorders. American Journal of Psychiatry, 164, 301–308.PubMedCrossRefGoogle Scholar
  27. Gregory, A. M. & Eley, T. C. (2007). Genetic influences on anxiety in children: What we’ve learned and where we’re heading. Clinical Child and Family Psychology Review. DOI  10.1007/s10567-007-0022-8.
  28. Gregory, A. M., Rijsdijk, F. V., Dahl, R. E., McGuffin, P., & Eley, T. C. (2006). Associations between sleep problems, anxiety and depression in twins aged 8 years. Pediatrics, 118, 1124–1132.PubMedCrossRefGoogle Scholar
  29. Gregory, A. M., Rijksdijk, F., Lau, J. Y. F., Napolitano, M., McGuffin, P., & Eley, T. C. (2007a). Interpersonal cognitions and associations with depressive symptoms in school-aged twins. Journal of Abnormal Psychology (in press).Google Scholar
  30. Kovacs, M. (1985). The Children’s Depression Inventory (CDI). Psychopharmacology Bulletin, 21, 995–1124.PubMedGoogle Scholar
  31. Lau, J. Y. F., & Eley, T. C. (2006). Changes in genetic and environmental influences on depressive symptoms across adolescence: A twin and sibling study. British Journal of Psychiatry, 189, 422–427 (in press).PubMedCrossRefGoogle Scholar
  32. Lau, J. Y. F., Rijsdijk, F. V., & Eley, T. C. (2006). I think, therefore I am: A twin study of attributional style in adolescents. Journal of Child Psychology and Psychiatry, 47, 696–703.PubMedCrossRefGoogle Scholar
  33. Little, R. J. A., & Rubin, D. B. (1987). Statistical analysis with missing data. New York: Wiley.Google Scholar
  34. Martin, N., Boomsma, D. I., & Machin, G. (1997). A twin-pronged attack on complex trait. Nature Genetics, 17, 387–392.PubMedCrossRefGoogle Scholar
  35. Mathews, A., & MacLeod, C. (2002). Induced processing biases have causal effects on anxiety. Cognition and Emotion, 16, 331–354.CrossRefGoogle Scholar
  36. Monga, S., Birmaher, B., Chiappetta, L., Brent, D., Kaufman, J., Bridge, J., et al. (2000). Screen for Child Anxiety-Related Emotional Disorders (SCARED): convergent and divergent validity. Depression and Anxiety, 12, 85–91.PubMedCrossRefGoogle Scholar
  37. Neale, M. C., Boker, S. M., Xie, G., & Maes, H. M. (2002). Mx: Statistical Modeling (6th ed.). VCU Box 900126, Richmond, VA 23298: Department of Psychiatry.Google Scholar
  38. Neale, M. C., & Cardon, L. R. (1992). Methodology for genetic studies of twins and families. Dordrecht: Kluwer.Google Scholar
  39. Nunn, J. D., Mathews, A., & Trower, P. (1997). Selective processing of concern-related information in depression. British Journal of Clinical Psychology, 36, 489–503.PubMedGoogle Scholar
  40. Plomin, R., Asbury, K., & Dunn, J. (2001). Why are children in the same family so different? Nonshared environment a decade later. Canadian Journal of Psychiatry, 46, 225–233.Google Scholar
  41. Price, T. S., Freeman, B., Craig, I. W., Petrill, S. A., Ebersole, L., & Plomin, R. (2000). Infant zygosity can be assigned by parental report questionnaire data. Twin Research, 3, 129–133.PubMedCrossRefGoogle Scholar
  42. Rice, F., Harold, G., & Thaper, A. (2002). The genetic aetiology of childhood depression: A review. Journal of Child Psychology and Psychiatry and Allied Disciplines, 43, 65–80.CrossRefGoogle Scholar
  43. Rutter, M., Pickles, A., Murray, R., & Eaves, L. (2001). Testing hypotheses on specific environmental causal effects on behavior. Psychological Bulletin, 127, 291–324.PubMedCrossRefGoogle Scholar
  44. Stein, M. B., Jang, K. L., & Livesley, W. J. (1999). Heritability of anxiety sensitivity: A twin study. American Journal of Psychiatry, 156, 246–251.PubMedGoogle Scholar
  45. Taghavi, M. R., Moradi, A. R., Neshat-Doost, H. T., Yule, W., & Dalgleish, T. (2000). Interpretation of ambiguous emotional information in clinically anxious children and adolescents. Cognition and Emotion, 14, 809–822.CrossRefGoogle Scholar
  46. Thapar, A., & McGuffin, P. (1994). A twin study of depressive symptoms in childhood. British Journal of Psychiatry, 165, 259–265.PubMedCrossRefGoogle Scholar
  47. Topolski, T. D., Hewitt, J. K., Eaves, L., Meyer, J. M., Silberg, J. L., Simonoff, E., et al. (1999). Genetic and environmental influences on ratings of manifest anxiety by parents and children. Journal of Anxiety Disorders, 13, 371–397.PubMedCrossRefGoogle Scholar
  48. Trouton, A., Spinath, F. M., & Plomin, R. (2002). Twins Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behaviour problems in childhood. Twin Research, 5, 444–448.PubMedCrossRefGoogle Scholar
  49. Williams, J. M. G., Watts, F. N., MacLeod, C., & Mathews, A. (1997). Cognitive psychology and emotional disorders (2nd ed.) Guilford: Wiley.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Thalia C. Eley
    • 1
  • Alice M. Gregory
    • 1
    • 3
  • Jennifer Y. F. Lau
    • 1
    • 4
  • Peter McGuffin
    • 1
  • Maria Napolitano
    • 1
  • Fruhling V. Rijsdijk
    • 1
  • David M. Clark
    • 2
  1. 1.Social, Genetic and Developmental Psychiatry CentreInstitute of Psychiatry, Kings College LondonLondonUK
  2. 2.Psychology DepartmentInstitute of Psychiatry, Kings College LondonLondonUK
  3. 3.Department of Psychology, Goldsmiths CollegeUniversity of LondonLondonUK
  4. 4.Mood and Anxiety ProgramNational Institute of Mental HealthBethesdaUSA

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