Anodic behaviour of fulvestrant and its voltammetric determination in pharmaceuticals and human serum on highly boron-doped diamond electrode using differential pulse adsorptive stripping voltammetry

  • B. Dogan-Topal
  • Dilek Kul
  • Sibel A. Ozkan
  • B. Uslu
Review Article
First Online:
Received:
Accepted:

Abstract

The electrochemical oxidation of fulvestrant was made on highly boron-doped diamond electrode using differential pulse adsorptive stripping voltammetry. The highest current intensities were obtained by applying +1.10 V during 150 s for boron-doped diamond electrode. For boron-doped diamond electrode, linear responses were obtained for the concentrations between 1 × 10−6 and 8 × 10−5 M in standard samples and between 1 × 10−6 and 4 × 10−5 M in serum samples. The repeatability of the method was 0.55 RSD% for differential pulse adsorptive stripping voltammetry. The analytical values of the method are demonstrated by quantitative determination of fulvestrant in pharmaceutical formulations and human serum, without the need for separation or complex sample preparation, since there was no interference from the excipients and endogenous substances. Selectivity, reproducibility, and accuracy of the developed methods were demonstrated by recovery studies.

Keywords

Fulvestrant Drug analysis Human serum Boron-doped diamond electrode Adsorptive stripping voltammetry 
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Notes

Acknowledgments

This study is produced from Ph.D. thesis of Pharm. Burcu Dogan-Topal (Ankara University, Health Science Institute). This research was supported by a Grant from Ankara University Scientific Project Foundation (Grant No. 20030803043) for Dr. Bengi Uslu. The authors would like to thank Asta Zeneca (Istanbul, Turkey) for providing standard fulvestrant and pharmaceutical dosage forms for developing the proposed method.

References

  1. 1.
    Vergote I, Abram P (2006) Ann Oncol 17:200CrossRefGoogle Scholar
  2. 2.
    Dodwell D, Vergote I (2005) Cancer Treat Rev 31:274CrossRefGoogle Scholar
  3. 3.
    Physicians Desk Reference (2005) PDR. Thomson PDR, Montvale, p 653Google Scholar
  4. 4.
    Dodwell D, Coombes G, Bliss JM, Kilburn LS, Johnston S (2008) Clin Oncol 20:321CrossRefGoogle Scholar
  5. 5.
    Uslu B, Ozkan SA (2007) Anal Lett 40:817CrossRefGoogle Scholar
  6. 6.
    Rao TN, Fujishima A (2000) Diam Relat Mater 9:384CrossRefGoogle Scholar
  7. 7.
    Lawrence NS, Pagels M, Meredith A, Jones TGJ, Hall CE, Pickles CSJ, Godfried HP, Banks CE, Compton RG, Jiang L (2006) Talanta 69:829CrossRefGoogle Scholar
  8. 8.
    Peleskov YV (2002) Russ J Electrochem 38:1275CrossRefGoogle Scholar
  9. 9.
    Dogan B, Tuncel S, Uslu B, Ozkan SA (2007) Diam Relat Mater 16:1695CrossRefGoogle Scholar
  10. 10.
    Wang J (1985) Stripping analysis: principles, instrumentation and applications. VCH, Deerfield BeachGoogle Scholar
  11. 11.
    Ribeiro FWP, Cardosa AS, Portela RR, Lima JES, Machado SAS, Lima-Neto P, De Souza D, Correira AN (2009) Electroanalysis 20:2031–2039CrossRefGoogle Scholar
  12. 12.
    Spataru T, Spataru N, Fujishima A (2007) Talanta 73:404–406CrossRefGoogle Scholar
  13. 13.
    Riley CM, Rosanske TW (1996) Development and validation of analytical methods. Elsevier, New YorkGoogle Scholar
  14. 14.
    Swartz ME, Krull IS (1997) Analytical method development and validation. Marcell Dekker, New York, p 53Google Scholar
  15. 15.
    Ermer J, Miller JH (eds) (2005) Method validation in pharmaceutical analysis. Wiley-VCH, VeinheimGoogle Scholar
  16. 16.
    Bievre P, Günzler H (2005) Validation in chemical measurements. Springer, New YorkCrossRefGoogle Scholar
  17. 17.
    Gosser DK (ed) (1994) Cyclic voltammetry. VCH, New YorkGoogle Scholar
  18. 18.
    Brown ER, Large RF, Weissberger A, Rossiter BW (eds) (1964) Physical methods of chemistry. Wiley Interscience, Rochester, p 423Google Scholar
  19. 19.
    Goyal RN, Gupta VK, Oyama M, Bachheti N (2006) Electrochem Commun 8:65CrossRefGoogle Scholar
  20. 20.
    Goyal RN, Jain N, Gurnani V (2001) Monatshefte fur Chemie 13:575Google Scholar
  21. 21.
    Lund H, Hammerich O (2001) Organic electrochemistry, 4th edn. Marcel Dekker, New York, p 590Google Scholar
  22. 22.
    SciFinder Scholar Programme, American Chemical Society, Version 2007Google Scholar
  23. 23.
    Wang J (1988) Electroanalytical techniques in clinical chemistry and laboratory medicine. VCH, New YorkGoogle Scholar
  24. 24.
    Kissenger PT, Heineman WR (eds) (1996) Laboratory techniques in electroanalytical chemistry, 2nd edn. Marcel Dekker, New YorkGoogle Scholar
  25. 25.
    ICH-Q2Bn-Validations of analytical procedures: methodology, Int. conf. harmonization of technical requirements for registration of pharmaceuticals for human use, Geneva, Nov 1996Google Scholar
  26. 26.
    Ozkan SA, Uslu B, Aboul-Enein HY (2003) Crit Rev Anal Chem 33:155CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • B. Dogan-Topal
    • 1
  • Dilek Kul
    • 2
  • Sibel A. Ozkan
    • 1
  • B. Uslu
    • 1
  1. 1.Department of Analytical Chemistry, Faculty of PharmacyAnkara UniversityTandoganTurkey
  2. 2.Faculty of PharmacyKaradeniz Technical UniversityTrabzonTurkey

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