This study aimed to compare the choroidal vascularity index (CVI) of eyes having Fuchs’ uveitis syndrome (FUS) with healthy fellow eyes (N).
This prospective, cross-sectional study included unilateral FUS cases and an age- and gender-matched healthy control group. Thirty-nine participants were included in the FUS group, and 24 age- and gender-matched individuals were randomly selected for the control group. Endothelial cell density (ECD) was measured using Tomey specular microscopy. Spectral-domain optical coherence tomography was used to acquire the choroidal images, and binarization was applied to the images. Two blinded investigators analyzed the CVI in both eyes of the FUS cases and the right eyes of the healthy control group.
CVI was found to be significantly decreased in FUS (p < 0.001). Additionally, ECD had a strong positive correlation with CVI (r = 0.383, p = 0.008).
CVI may provide information about the chronicity of the disease.
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Availability of data and materials
The data supporting our findings can be found at Van Yuzuncu Yil University, Dursun Odabas Faculty of Medicine, Ophthalmology Department, Uveitis section secretary.
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Conflict of interest
All the authors declare that they have no conflict of interest.
Ethical approval and consent to participate
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by Van Yuzuncu Yil University, Dursun Odabas Faculty of Medicine, Surgical and Pharmaceutical Research Ethics Board.
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Ozer, M.D., Batur, M., Tekin, S. et al. Choroid vascularity index as a parameter for chronicity of Fuchs’ uveitis syndrome. Int Ophthalmol (2020). https://doi.org/10.1007/s10792-020-01309-4
- Fuchs’ uveitis syndrome
- Endothelial cell density
- Choroidal vascularity index
- Spectral-domain optical coherence tomography