Conjunctival melanoma in patients with xeroderma pigmentosum: a series of four cases
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To study the demographic features, treatment, histopathology, and outcomes in patients of xeroderma pigmentosum (XP) with conjunctival melanoma.
Retrospective case series.
The median age at presentation was 18 years (range 9–30 years). There were three females and one male patient presenting with a median duration of symptoms of 3 months (range 1–60 months). The tumor was located in the bulbar conjunctiva in all 4 patients. All patients had corneal involvement by the tumor. The median tumor basal diameter was 7 mm (range 4–15 mm). Wide tumor excisional biopsy with alcohol keratoepithelectomy, cryotherapy to the free margins, and amniotic membrane grafting was done in three patients. One patient underwent orbital exenteration for extensive tumor. One patient also received adjuvant plaque brachytherapy for microscopic residual tumor. Over a median follow-up of 22 months (range 2–101 months), there were no recurrences, metastasis, or death.
Conjunctival melanoma in XP is rare and manifests at a younger age.
KeywordsEye Conjunctiva Tumor Melanoma Xeroderma pigmentosum
Support provided by the Operation Eyesight Universal Institute for Eye Cancer (SK) and Hyderabad Eye Research Foundation (SK), Hyderabad, India. The funders had no role in the preparation, review, or approval of the manuscript.
None to disclose.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Human and animal participants
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants or parents/guardians included in the study.