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Medium-term clinical outcomes following Xen45 device implantation

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Abstract

Purpose

To evaluate medium-term clinical outcomes with microstent XEN® 45 Gel Stent (Allergan Dublin, Ireland) for treatment of primary open-angle glaucoma (POAG).

Material and methods

This is a retrospective, descriptive and observational study involving 93 eyes from 63 patients who had undergone POAG surgery with a XEN® 45 Gel Stent implantation and had been followed up and controlled between 12 and 36 months.

Results

IOP dropped from 18.23 ± 5.00 mmHg pre-op to 14.16 ± 2.14, 14.47 ± 2.16 and 14.63 ± 1.91 at 1, 2 and 3 years after surgery (p = 0.000, 0.000 and 0.001) consecutively. Mean number of medications dropped from 1.87 ± 0.94 preoperatively to 0.31 ± 0.69, 0.34 ± 0.63 and 1.00 ± 0.88 (p = 0.000, 0.000 and 0.017) at 12, 24 and 36 months. Mean visual field deviation values never turned out to be significant for any of the follow-up visit data. A total of 94.6% of the surgical procedures turned out to be complication-free. In one surgery, the procedure failed and 18 months later other device was implanted.

Conclusion

POAG surgical procedures with XEN® 45 Gel Stent implants are a safe and effective treatment approach.

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Acknowledgements

This study was supported by Allergan via an independent and unrestricted research grant. Neither honoraria nor payments were made for authorship. It should be noted that Allergan S.A. was not involved in the development of the study.

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Authors and Affiliations

  1. IOA Madrid, C/Galileo 104, 28003, Madrid, Spain

    Aitor Fernández-García, Ying Zhou, Francisco Poyales & Nuria Garzón

  2. Optometry and Vision Department, Faculty of Optics and Optometry, Complutense University of Madrid, Madrid, Spain

    Mercedes García-Alonso, Henry D. Andrango & Nuria Garzón

Authors
  1. Aitor Fernández-García
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  2. Ying Zhou
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  3. Mercedes García-Alonso
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  4. Henry D. Andrango
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  5. Francisco Poyales
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  6. Nuria Garzón
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Corresponding author

Correspondence to Nuria Garzón.

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Fernández-García, A., Zhou, Y., García-Alonso, M. et al. Medium-term clinical outcomes following Xen45 device implantation. Int Ophthalmol 40, 709–715 (2020). https://doi.org/10.1007/s10792-019-01232-3

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  • DOI: https://doi.org/10.1007/s10792-019-01232-3

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