Ocular biometric parameters are associated with non-contact tonometry measured intraocular pressure in non-pathologic myopic patients

  • Yazhen Ma
  • Yanping Ma
  • Chenli Feng
  • Minqian Shen
  • Yuanzhi YuanEmail author
Original Paper



This research aimed to investigate effects and risk factors on non-contact tonometer (NCT) readings in healthy myopic subjects by employing cross-sectional study design.


Totally, sixty otherwise healthy myopic volunteers (mean 28.4 years old) with 90% female were recruited in ophthalmic clinic. The routine ophthalmic tests, refractive evaluation, examination central corneal thickness (CCT), depth of anterior chamber, axial length, corneal curvature, white-to-white and NCT were assessed at baseline. The linear-mixed model was utilized to evaluate correlation between the readings and ocular biometric parameters.


For population in this study, mean spherical equivalents were − 4.85 ± 1.79 diopters in right eyes and − 4.63 ± 1.95 diopters in left eyes. Meanwhile, 28.3% of the eyes had a refractive error exceeding − 6.0 diopters. The mean NCT reading was 15.02 ± 3.02 mmHg in left eyes and 15.33 ± 2.96 mmHg in right eyes. Among the factors analyzed, CCT was the most significant parameter associated with NCT readings. After adjusting for the other factors, per one standard deviation increase of central corneal thickness (36.11 μm) was associated a 1.14 (95% confidence interval 0.53–1.77) mmHg elevated NCT reading. The average central corneal curvature, age and spherical equivalence were also significantly and independently associated with NCT readings.


Central corneal thickness, age, corneal curvature and degree of myopia were independently associated with NCT measured intraocular pressure. Central corneal thickness is one of the most influential factors.


Central corneal thickness Intraocular pressure Myopia Non-contact tonometer (NCT) 



This study was granted by the Science and Technology Commission of Shanghai Municipality (Grant No. 11DZ1921206) and Fudan Youth Foundation.

Compliance with ethical standards

Conflict of interest

All authors declare no competing financial or commercial interests in this manuscript.

Ethical approval

This research has been approved by the Ethic Committee of Zhongshan Hospital, Fudan University (Shanghai, China). Meanwhile, this study was performed based on the guidance of Declaration of Helsinki. All of subjects have approved this study and provided the written informed consents. This research was taken place from October 2010 to December 2010 in Zhongshan Hospital, Fudan University.

Informed consent

Informed consent was obtained from all individual participants included in this study.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Yazhen Ma
    • 1
  • Yanping Ma
    • 1
  • Chenli Feng
    • 2
  • Minqian Shen
    • 2
  • Yuanzhi Yuan
    • 2
    • 3
    Email author
  1. 1.Taikang Xianlin Drum Tower Hospital Affiliated to Medical College of Nanjing UniversityNanjingChina
  2. 2.Department of Ophthalmology, Zhongshan HospitalFudan UniversityShanghaiChina
  3. 3.Centre for Evidence-Based MedicineFudan UniversityShanghaiChina

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