International Ophthalmology

, Volume 39, Issue 12, pp 2923–2928 | Cite as

Appearance of herpes simplex keratitis on anterior segment optical coherence tomography

  • Wael Soliman
  • Mohamed A. Nassr
  • Khaled AbdelazeemEmail author
  • Ashraf K. Al-Hussaini
Original Paper



To describe the anterior segment AS-OCT findings of herpetic simplex keratitis.


Forty-two eyes of 42 patients with proven herpetic keratitis of varying severity were included in this prospective, observational, non-comparative case series study. All subjects underwent ophthalmologic examination and AS-OCT imaging.


Twenty-five of the 42 eyes (59.5%) had sub-epithelial infiltrates. In 11 of these cases, the overlying epithelium appeared intact, but in 14 cases, hydropic changes, heaping, and defects were observed. Seventeen eyes (40.5%) showed stromal involvement: six cases with scar at presentation and one case associated with uveitis. Stromal infiltrates were also seen, in ten cases, as a diffuse or local lentiform or spindle-shaped hyper-reflective area in the stroma.


Herpetic keratouveitis has characteristic features on AS-OCT images. This study demonstrates that herpetic keratitis also has characteristic AS-OCT features, including sub-epithelial infiltration and specific stromal hyper-reflective patterns. These features are not unique to herpetic keratitis, but AS-OCT imaging may provide useful supplementary information for diagnosing and monitoring herpetic keratitis.


Herpes simplex Herpetic keratitis Anterior segment optical coherence tomography 



We would like to thank Editage ( for English language editing.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was reviewed and approved by the Assiut University Institutional Review Board (Assiut, Egypt). All study conduct adhered to the tenets of the Declaration of Helsinki.

Informed consent

Written informed consent was obtained from all individual participants included in this study. Patients had the right to not participate in this study and the right to withdraw from the study without compromising regular, full clinical care.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Ophthalmology, Faculty of MedicineAssiut UniversityAssiutEgypt
  2. 2.North West Anglia NHS Foundation TrustPeterboroughUK
  3. 3.Department of OphthalmologyAssiut University HospitalsAssiutEgypt

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