Aqueous humor IL-8, IL-10, and VEGF levels in Fuchs’ uveitis syndrome and Behçet’s uveitis
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This study investigated the levels of interleukin (IL)-8, IL-10, and vascular endothelial growth factor (VEGF) in the aqueous humor (AqH) of patients with Behçet’s uveitis (BU) and Fuchs’ uveitis syndrome (FUS) during an inactive period and compared these levels with those in the AqH of noninflammatory healthy control subjects.
This prospective and case–control study included 33 patients (16 patients with BU and 17 patients with FUS) and 35 control subjects. IL-8, IL-10, and VEGF levels in the AqH were quantified by performing sandwich enzyme-linked immunosorbent assay. Kruskal–Wallis test was used to compare the cytokine levels in the different groups, and statistical significance was set at p < 0.05.
IL-8 levels were significantly higher in the AqH of patients with BU and FUS than in the AqH of control subjects (p < 0.001 and p < 0.001, respectively). IL-10 levels were significantly lower in the AqH of patients with BU than in the AqH of patients with FUS and of control subjects (p = 0.001 and p < 0.001, respectively). Although VEGF levels were higher in the AqH of patients with FUS than in the AqH of patients with BU and of control subjects, the difference was significant only between patients with FUS and control subjects (p < 0.001).
We observed a significant decrease in IL-10 levels in the AqH of patients with BU and a significant increase in VEGF levels in the AqH of patients with FUS compared to controls. IL-8 and VEGF levels showed no significant difference among uveitis patients.
KeywordsBehçet’s uveitis Fuchs’ uveitis syndrome IL-8 IL-10 VEGF
The authors have no financial interest in any materials used in the study.
The authors have indicated that they have no financial relationships with any company/corporation. This work was supported by Ankara Department of Turkish Ophthalmological Association [Grant Number 2015-144].
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest. The authors alone are responsible for the content and writing of this article.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 1.Oppenheim JJ, Ruscetti FW, Faltynek C (1994) Cytokines. In: Stites DP, Terr AI, Parslow TG (eds) Basic and clinical immunology, 8th edn. Norwalk, Connecticut, pp 105–123Google Scholar
- 2.Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V (2010) Evolutionary divergence and functions of the human interleukin (IL) gene family. Hum Genom 5:30–55Google Scholar
- 19.Vinores SA, Chan CC, Vinores MA, Matteson DM, Chen YS, Klein DA et al (1998) Increased vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGFbeta) in experimental autoimmune uveoretinitis: upregulation of VEGF without neovascularization. J Neuroimmunol 89:43–50PubMedGoogle Scholar
- 21.International Study Group for Behçet’s Disease (1990) Criteria for diagnosis of Behçet’s disease. Lancet 335:1078–1080Google Scholar