Diabetes mellitus is associated with dry eye syndrome: a meta-analysis
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Dry eye is the most common eye disorder of tears and ocular surface. However, the extent to which diabetes mellitus may confer risk of dry eye remains uncertain. The aim of this study was to perform a meta-analysis that synthesizes the association between diabetes mellitus and dry eye.
Case–control studies were selected from the Medline, Embase, Cochrane database from January 2000 to March 2018. Two reviewers screened potential studies, and eligible studies were included according to keywords and predefined criteria. We calculated the overall risk estimates by using a fixed-effect model or a random-effects model in relation to heterogeneity.
A total of four studies were included in our meta-analysis consisting of 2,504,794 persons. Our study showed a significant association between diabetes mellitus and the risk of dry eye syndrome (OR 1.30; 95% CI 1.08–1.57; P value = 0.006). However, the heterogeneity was observed (P value < 0.001, I2 = 95.2%).
Our meta-analysis suggests that diabetes mellitus has a significant association with the risk of dry eye. However, this result is limited by heterogeneity. Further prospective and concise studies are needed to confirm the association between diabetes mellitus and dry eye.
KeywordsDry eye Diabetes mellitus Observational study Meta-analysis
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
This article does not contain any studies with human participants or animals performed by any of the authors.
- 2.Lemp MA, Badouin C, Baum J et al (2007) The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye workshop. Ocul Surf 5:75–92Google Scholar
- 3.Lin MC, Polse KA (2015) Improving care for patients with dry eye symptoms: see what the experts say. Optom Vis Sci Off Publ Am Acad Optom 92:e342–e349Google Scholar
- 5.Hom M, De Land P (2006) Self-reported dry eyes and diabetic history. Optom St Louis Mo 77:554–558Google Scholar
- 8.Achtsidis V, Eleftheriadou I, Kozanidou E et al (2014) Dry eye syndrome in subjects with diabetes and association with neuropathy. Diabetes Care 37:210–211Google Scholar
- 11.Schaumberg DA, Dana R, Buring JE, Sullivan DA (2009) Prevalence of dry eye disease among US men: estimates from the Physicians’ Health Studies. Arch Ophthalmol Chic Ill 127:763–768Google Scholar
- 16.Wang T-J, Wang I-J, Hu C-C, Lin H-C (2012) Comorbidities of dry eye disease: a nationwide population-based study. Acta Ophthalmol (Copenh) 90:663–668Google Scholar
- 18.Yang W, Yang Y-N, Cao J et al (2015) Risk factors for dry eye syndrome: a retrospective case–control study. Optom Vis Sci Off Publ Am Acad Optom 92:e199–e205Google Scholar
- 22.Jie Y, Xu L, Wu YY, Jonas JB (2009) Prevalence of dry eye among adult Chinese in the Beijing Eye Study. Eye Lond Engl 23:688–693Google Scholar
- 23.Jeong HS, Lim JS, Oh DK et al (2011) Prevalence and risk factors of dry eye syndrome in the Incheon Area. J Korean Ophthalmol Soc 52:1135–1141Google Scholar
- 33.Yu L, Chen X, Qin G et al (2008) Tear film function in type 2 diabetic patients with retinopathy. Ophtalmol Int J Ophthalmol Z Augenheilkd 222:284–291Google Scholar
- 42.Inoue K, Okugawa K, Amano S et al (2005) Blinking and superficial punctate keratopathy in patients with diabetes mellitus. Eye Lond Engl 19:418–421Google Scholar
- 45.Fuerst N, Langelier N, Massaro-Giordano M et al (2014) Tear osmolarity and dry eye symptoms in diabetics. Clin Ophthalmol Auckl NZ 8:507–515Google Scholar