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An assessment of ocular elasticity using real time ultrasound and ocular response analyzer in active or remission rheumatoid arthritis

  • Mehmet Erol Can
  • Özlem Unal
  • Meltem Ece Kars
  • Sukran Erten
  • Gamze Dereli Can
  • Necati Duru
  • Nurullah Cagil
Original Paper
  • 14 Downloads

Abstract

Purpose

To investigate the elasticity of ocular structures in patients with rheumatoid arthritis (RA) without ocular involvement.

Methods

The study included 56 RA patients (study group) and 24 healthy volunteers as the control group. The rheumatoid arthritis patients were divided into two subgroups as those in active phase (Group 1, n = 25) or in remission phase (Group 2, n = 31) according to the disease activity index (DAS 28) score. The elastography values of the ratio of orbital fat-sclera (ROF/S) were measured with real-time US elastography, and corneal mechanical values were measured with the Reichert Ocular Response Analyzer in each eye.

Results

The mean ROF/S value was 5.2 ± 1.8 in Group 1, 0.7 ± 0.4 Group 2, and 0.6 ± 0.1 in the control group. There was a significant difference between the Group 1 and control group with regard to ROF/S (p < 0.001), but no significant difference was determined between Group 2 and control group (p > 0.05). The mean ROF/S value was a significant difference between the Group 1 and 2 (p < 0.001). ROF/S was significantly correlated with DAS-28 and C-reactive protein (CRP) (r = 0.816, p < 0.001 and r = 0.259, p = 0.006).

Conclusions

ROF/S was significantly increased in patients in the active phase of RA. Findings revealed that ocular tissue structural changes may occur in the active phase and these could be related to ocular complications as a prognostic factor.

Keywords

Rheumatoid arthritis Ocular elasticity Ultrasound elastography DAS 28 

Notes

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of OphthalmologyYuksek Ihtisas Training and Research HospitalBursaTurkey
  2. 2.Department of Radiology, Yildirim Beyazit University Faculty of MedicineAnkara Ataturk Training and Research HospitalAnkaraTurkey
  3. 3.Department of Ophthalmology, Yildirim Beyazit University Faculty of MedicineAnkara Ataturk Training and Research HospitalAnkaraTurkey
  4. 4.Department of Rheumatology, Yildirim Beyazit University Faculty of MedicineAnkara Ataturk Training and Research HospitalAnkaraTurkey
  5. 5.Department of OphthalmologyKayseri Training and Research HospitalKayseriTurkey

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