International Ophthalmology

, Volume 38, Issue 6, pp 2593–2597 | Cite as

Efficacy of locally produced Latanoprost in the control of intraocular pressure in patients with primary open-angle glaucoma

  • Pir Salim MaharEmail author
  • Nadeem H. Butt
  • Syed Imtiaz Ali
Original Paper



To determine the efficacy of locally produced Latanoprost in reducing the intraocular pressure (IOP) in patients with Primary open-angle glaucoma (POAG).


Open-label, non-comparative, observational case study with non-probability purposive sampling.


A total of 48 patients (94 eyes) of either gender were recruited from glaucoma clinic with the diagnosis of POAG, having IOP of more than 21 mmHg. Patients were commenced on locally produced Latanoprost (Vislat 0.005%). IOP was subsequently measured at 4 weeks and 12 weeks, respectively. The primary end point was reduction in IOP at 12 weeks after the initiation of treatment.


A total of 48 patients (94 eyes) were recruited from glaucoma clinic. The average IOP of our patients at baseline was 28.6 ± 8.1 mmHg, decreasing to 21.3 ± 10.6 mmHg at 4 weeks, indicating a drop of 19.1% (P < 0.001). IOP further decreased to 20.3 ± 8.7 mmHg after 3 months of treatment indicating a decrease of 23.3% (P < 0.001). A decrease in IOP occurred in 51 eyes (71.8%) at 4 weeks after treatment, improving to 54 eyes (76%) at 3-month follow-up. Twenty eyes (28.1%) did not show any change in IOP at 4 weeks. However, after 3-month follow-up only 17 eyes (23.9%) did not reveal any change in IOP.


Our results showed a decrease in IOP of 19.1% after 4 weeks, increasing to 23.3% at 12 weeks in cohort of 37 patients (72 eyes) treated with locally produced Latanoprost (Vislat 0.005%).


Latanoprost Intraocular pressure Primary open-angle glaucoma 



We are thankful to Dr. Mujahid Inam, Dr. Nasir Memon and Dr. Shahid Rashidi for recruiting and enrolling the patients, Muhammad Faisal Fahim for statistical analysis and Azfar Ali for typing the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2017

Authors and Affiliations

  • Pir Salim Mahar
    • 1
    • 2
    Email author
  • Nadeem H. Butt
    • 3
  • Syed Imtiaz Ali
    • 4
  1. 1.Isra Postgraduate Institute of OphthalmologyAl-Ibrahim Eye HospitalMalir, KarachiPakistan
  2. 2.Aga Khan University HospitalKarachiPakistan
  3. 3.Allama Iqbal Medical CollegeLahorePakistan
  4. 4.Al-Nafees Medical CollegeIslamabadPakistan

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