International Ophthalmology

, Volume 38, Issue 6, pp 2451–2462 | Cite as

Semiautomatic procedure to assess changes in the eye accommodative system

  • Aikaterini I. Moulakaki
  • Daniel Monsálvez-Romín
  • Alberto Domínguez-Vicent
  • José J. Esteve-Taboada
  • Robert Montés-Micó
Original Paper



The aim of this pilot study was to evaluate a new semiautomatic procedure to assess in vivo changes in the crystalline lens and ciliary muscle during accommodation.


A total of 14 subjects were divided into two groups, young (aged between 20 and 25 years) and adult (aged between 35 and 40 years), and measured with an anterior segment optical coherence tomography. A semiautomatic procedure was implemented to measure the central lens thickness (CLT), anterior lens radius (ALR) and the ciliary muscle area (CMA) for the unaccommodated eye and for a vergence of − 3.00 D.


The CLT increase for each population group was smaller than 5%, and the dispersion of each group was similar between them. Contrariwise, the reduction in the ALR was about 30% for both groups, although the young one showed the largest variability. The CMA increase was smaller than 30% for both groups, and the dispersion was similar between them. For each metric, differences between both groups were not statistically significant.


The semiautomatic procedure seems to be useful for the in vivo analysis of the accommodative system. Additionally, the results obtained showed that changes in the CLT were much smaller compared to those obtained for the ALR or CMA.


Crystalline lens Ciliary muscle Presbyopia Accommodation Optical coherence tomography Ageing 



This study was funded by Ministerio de Economía y Competitivad Research Project SAF2013-44510-R with ERDF funds (European Regional Development Fund) from European Union. Aikaterini I. Moulakaki is a “Marie Curie Early Stage Researcher” from the AGEYE Initial Training Network Program FP7-People-2013-608049 Project, Daniel Monsálvez-Romín is a “Formación de Profesorado Universitario” grantee (FPU13/05332, Ministerio de Educación, Cultura y Deporte), and Alberto Domínguez-Vicent is an “Atracció de Talent” grantee (UV-INV-PREDOC13-110412, University of Valencia, Spain).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  1. 1.Optometry Research Group (GIO), Optics, Optometry and Vision Sciences DepartmentUniversity of ValenciaBurjassotSpain

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