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International Ophthalmology

, Volume 38, Issue 6, pp 2669–2675 | Cite as

Choroidal metastasis from non-small-cell lung cancer responsive to Osimertinib: a case report

Efficacy of a third-generation epidermal growth factor tyrosine kinase inhibitor
  • Morara Mariachiara
  • Ruatta Celeste
  • Foschi FedericoEmail author
  • Balducci Nicole
  • Ciardella Antonio
Case Report

Abstract

Purpose

To report a case of a choroidal metastasis from a non-small-cell lung cancer (NSCLC) with an epidermal growth factor receptor (EGFR) mutation, which responded to Osimertinib, a third-generation EGFR-tyrosine kinase inhibitor (TKI).

Background

First- and second-generation EGFR-TKis have been widely used for advanced NSCLC patients; however, acquired resistance to these inhibitors, as T790M mutation, could be present in resistant cases. Third-generation EGFR-TKis have emerged as potential therapeutics to overcome this resistance.

Methods

A 54-year-old lady, affected by pulmonary adenocarcinoma with systemic metastases, was diagnosed with choroidal metastasis and since tumor biopsy was positive for the EGFR-T790M mutation, she was included in ASTRIS study, and she received 80 mg tablet of Osimertinib once a day.

Results

After a 2-week course of daily therapy with Osimertinib, the improvement of visual acuity was evident with the marked disappearance of visual field defects. We also report a dramatic anatomical reduction of choroidal mass on fundus examination and SD-OCT. These features remained stable at the 4-month follow-up visit.

Conclusion

This report demonstrates that Osimertinib is effective for choroidal metastasis of NSCLC harboring an EGFR-T790M mutation, which has progressed on or after first- or second-generation EGFR-TKI therapy.

Keywords

Osimertinib Choroidal metastasis Carcinoma Non-small-cell lung Receptor Epidermal growth factor Tyrosine kinase inhibitor 

Notes

Compliance with ethical standards

Conflict of interest

All the authors have any financial/conflicting interest to disclose.

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Morara Mariachiara
    • 1
  • Ruatta Celeste
    • 2
  • Foschi Federico
    • 2
    Email author
  • Balducci Nicole
    • 1
  • Ciardella Antonio
    • 1
  1. 1.Ophthalmology Unit, S. Orsola-Malpighi HospitalUniversity of BolognaBolognaItaly
  2. 2.University of BolognaBolognaItaly

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