International Ophthalmology

, Volume 38, Issue 6, pp 2397–2402 | Cite as

Blood coagulation parameters after intravitreal injection of aflibercept in patients with neovascular age-related macular degeneration

  • Hasan AltinkaynakEmail author
  • Meltem Ece Kars
  • Piraye Zeynep Kurkcuoglu
  • Nagihan Ugurlu
Original Paper



The aim of this study was to evaluate the effect of intravitreal injection of aflibercept (IVA) on blood coagulation tests in neovascular age-related macular degeneration (AMD) patients.


Thirty-four patients with neovascular AMD (study group) and 32 healthy individuals (control group) were enrolled. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured at different times in patients with neovascular AMD.


The levels of PT and aPTT after IVA were decreased at 1 month after the first injection and 1 month after the second injection compared to the baseline measurement in the study group.


IVA may cause a decrease in the levels of PT and aPTT at 1 month after the first injection and 1 month after the second injection although these results are not statistically significant in our study.


Activated partial thromboplastin time Age-related macular degeneration Aflibercept Arterial thrombotic events Prothrombin time 


Compliance with ethical standards

Conflict of interest

The authors declare no financial or proprietary interests.

Ethical approval

The study protocol followed the principles in the declaration of Helsinki.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Hasan Altinkaynak
    • 1
    Email author
  • Meltem Ece Kars
    • 2
  • Piraye Zeynep Kurkcuoglu
    • 3
  • Nagihan Ugurlu
    • 2
  1. 1.Department of OphthalmologyAnkara Atatürk Education and Research HospitalAnkaraTurkey
  2. 2.Department of OphthalmologyYıldırım Beyazıt University, Ankara Atatürk Education and Research HospitalAnkaraTurkey
  3. 3.Department of OphthalmologyWorld Eye HospitalAnkaraTurkey

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