International Ophthalmology

, Volume 38, Issue 6, pp 2289–2294 | Cite as

Peripapillary retinal nerve fiber layer thickness in preeclampsia and eclampsia

  • Maliheh Arab
  • Morteza EntezariEmail author
  • Hamidreza Ghamary
  • Alireza Ramezani
  • Adele Ashori
  • Arman Mowlazadeh
  • Mehdi Yaseri
Original Paper



To evaluate peripapillary retinal nerve fiber layer (RNFL) thickness during and after pregnancy in pregnant women with preeclampsia or eclampsia and compare it with normotensive pregnant women as controls.


In a prospective comparative case–control study 35 women (70 eyes) with mild to moderate preeclampsia, 70 women (140 eyes) with severe preeclampsia and eclampsia, and 44 (88 eyes) healthy pregnant women were enrolled in three groups. Peripapillary RNFL thickness in three groups was measured after 28 weeks of pregnancy and 2 months postpartum by using optical coherence tomography. Mean and quadratic RNFL thickness changes were compared within and among the groups.


Mean peripapillary RNFL thickness decreased significantly from 104 ± 10, 104 ± 23, and 106 ± 9 µm during pregnancy to 101 ± 10, 96 ± 10, and 103 ± 9 µm 2 months after pregnancy in the mild to moderate preeclampsia, severe preeclampsia and eclampsia, and healthy pregnant women groups, respectively (P < 0.001 for all). While the difference among the groups was insignificant during pregnancy, it reached to a significant level after delivery (P = 0.006). The highest reduction in mean RNFL thickness (6 ± 10 µm) occurred in the severe preeclampsia and eclampsia groups.


In relation to the time of pregnancy, peripapillary RNFL reduced in preeclamptic and eclamptic cases as well as in normotensive pregnant women at 2 months postpartum. This reduction was more in the severe forms of pregnancy-induced hypertension.


Pregnancy Preeclampsia Eclampsia Optical coherence tomography Retinal nerve fiber layer thickness 


Compliance with ethical standards

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or nonfinancial interest in the subject matter or materials discussed in this manuscript.


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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Maliheh Arab
    • 1
  • Morteza Entezari
    • 1
    Email author
  • Hamidreza Ghamary
    • 1
  • Alireza Ramezani
    • 1
  • Adele Ashori
    • 1
  • Arman Mowlazadeh
    • 1
  • Mehdi Yaseri
    • 1
  1. 1.Ophthalmic Research Center, Imam Hossein Medical CenterShahid Beheshti University of Medical SciencesTehranIran

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