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Optical coherence tomography angiography findings in Susac’s syndrome: a case report

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Abstract

Purpose

To report clinical features of Susac’s syndrome (SS) using optical coherence tomography angiography (OCTA).

Methods

Case report.

Results

A 25-year-old Caucasian female with a history of non-pulsatile migraine, tinnitus, and verbal apraxia complaining of peripheral scotoma in left eye due to branch retinal arteriole occlusion (BRAO) was diagnosed as having SS after audiometric test, brain magnetic resonance imaging, and multimodal retinal imaging. Fundus biomicroscopy and fluorescein angiography (FA) revealed the presence of retinal ischemia in the area of BRAO. The OCTA images showed decreased vascular perfusion of both superficial and deep plexuses in the area of the occluded arteriole with increase of vascular density values after treatment with intravenous glucocorticoids, cyclophosphamide, and aspirin.

Conclusions

OCTA offers a valid alternative to the standard invasive FA, evaluating vascular perfusion in all capillary plexuses, and monitoring retinal microvascular flow changes during the course of BRAO, without dye injection.

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References

  1. Susac JO, Hardman JM, Selhorst JB (1979) Microangiopathy of the brain and retina. Neurology 29:313–316

    Article  PubMed  CAS  Google Scholar 

  2. Susac JO (1994) Susac’s syndrome: the triad of microangiopathy of the brain and retina with hearing loss in women. Neurology 44:591–593

    Article  PubMed  CAS  Google Scholar 

  3. Agarwal A, Soliman M, Sarwar S, Sadiq MA, Do DV, Nguyen QD, Sepah YJ (2016) Spectral-domain optical coherence tomography evaluation of retinal structure in patients with Susacs syndrome. Retin Cases Brief Rep 0:1–3

    Google Scholar 

  4. Mastropasqua R, Di Antonio L, Di Staso S, Agnifili L, Di Gregorio A, Ciancaglini M, Mastropasqua L (2015) Optical coherence tomography angiography in retinal vascular diseases and choroidal neovascularization. J Ophthalmol 2015:343515

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Bonini Filho MA, Adhi M, de Carlo TE, Ferrara D, Baumal CR, Witkin AJ, Reichel E, Kuehlewein L, Sadda SR, Sarraf D, Duker JS, Waheed NK (2015) Optical coherence tomography angiography in retinal artery occlusion. Retina 35:2339–2346

    Article  PubMed  Google Scholar 

  6. Rennebohm RM, Egan RA, Susac JO (2008) Treatment of Susac’s syndrome. Curr Treat Options Neurol 10:67–74

    Article  PubMed  Google Scholar 

  7. Spaide RF, Klancnik JM Jr, Cooney MJ (2015) Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol 133:45–50

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Ophthalmology Clinic, Moorfields Eye Hospital, London, EC1V 2PD, UK

    Rodolfo Mastropasqua

  2. Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D’Annunzio Chieti-Pescara, 66100, Chieti, Italy

    Lisa Toto, Alfonso Senatore, Alessandro D’Uffizi & Luca Di Antonio

  3. Ophthalmology Clinic, University of Marche, Ancona, Italy

    Piergiorgio Neri & Cesare Mariotti

  4. Radiology Division, Santo-Spirito Hospital, Pescara, Italy

    Marica Tina Maccarone

Authors
  1. Rodolfo Mastropasqua
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  2. Lisa Toto
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  3. Alfonso Senatore
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  4. Alessandro D’Uffizi
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  5. Piergiorgio Neri
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  6. Cesare Mariotti
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  7. Marica Tina Maccarone
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  8. Luca Di Antonio
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Corresponding author

Correspondence to Lisa Toto.

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Conflict of interest

Authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Cite this article

Mastropasqua, R., Toto, L., Senatore, A. et al. Optical coherence tomography angiography findings in Susac’s syndrome: a case report. Int Ophthalmol 38, 1803–1808 (2018). https://doi.org/10.1007/s10792-017-0653-9

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  • DOI: https://doi.org/10.1007/s10792-017-0653-9

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