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International Ophthalmology

, Volume 37, Issue 4, pp 1017–1024 | Cite as

Biomechanical evaluation of cornea in patients with ankylosing spondylitis

  • Mehtap Caglayan
  • Ozge Sarac
  • Pinar Kosekahya
  • Sukran Erten
  • Berna Ayan
  • Nurullah Cagil
Original Paper
  • 141 Downloads

Abstract

Purpose

The aim of this study was to evaluate the corneal biomechanical parameters in patients with ankylosing spondylitis (AS) and to compare them with the healthy subjects.

Methods

Sixty patients with AS (study group) and 60 healthy subjects (control group) were enrolled in this prospective study. The study group was further classified as active (n:30) and inactive (n:30). After detailed ophthalmological examination including intraocular pressure (IOP) measurement with Goldmann applanation tonometer (IOPGAT), corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated IOP (IOPcc), and Goldmann-correlated IOP (IOPg) were measured with the Reichert Ocular Response Analyzer (ORA). Central corneal thickness (CCT) was measured with the Spectral-Domain Optical Coherence Tomography (SD-OCT).

Results

The study group’s mean CH, CCT, IOPg, and IOPGAT values were lower than the control group (p < 0.05 for all variables). The mean CH, CRF, CCT, IOPg, and IOPGAT values were higher in active patients when compared to the inactive ones (p < 0.001, p < 0.001, p = 0.013, p = 0.021, and p = 0.002, respectively).

Conclusions

AS patients have lower CCT, CH, IOPg, and IOPGAT when compared with healthy subjects. In the active stage of AS, patients present with higher levels of corneal biomechanical parameters with thicker corneas. IOPcc is a more accurate measurement than IOPGAT or IOPg in AS patients.

Keywords

Ankylosing spondylitis Central corneal thickness Corneal hysteresis Corneal resistance factor 

Notes

Compliance with ethical standards

Conflict of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Mehtap Caglayan
    • 1
  • Ozge Sarac
    • 1
  • Pinar Kosekahya
    • 2
  • Sukran Erten
    • 3
  • Berna Ayan
    • 1
  • Nurullah Cagil
    • 4
  1. 1.Ophthalmology DepartmentAtaturk Research and Training HospitalAnkaraTurkey
  2. 2.Ulucanlar Eye Research and Training HospitalAnkaraTurkey
  3. 3.Rheumatology Department, Atatürk Research and Training HospitalYildirim Beyazit UniversityAnkaraTurkey
  4. 4.Ophthalmology Department, Atatürk Research and Training HospitalYildirim Beyazit UniversityAnkaraTurkey

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