International Ophthalmology

, Volume 35, Issue 3, pp 365–373

Incidence and risk factors for retinopathy of prematurity in extreme low birth weight Chinese infants

  • Gordon S. K. Yau
  • Jacky W. Y. Lee
  • Victor T. Y. Tam
  • Catherine C. L. Liu
  • Benjamin C. Y. Chu
  • Can Y. F. Yuen
Original Paper

DOI: 10.1007/s10792-014-9956-2

Cite this article as:
Yau, G.S.K., Lee, J.W.Y., Tam, V.T.Y. et al. Int Ophthalmol (2015) 35: 365. doi:10.1007/s10792-014-9956-2

Abstract

The objective of this study is to determine the incidence and risk factors of retinopathy of prematurity (ROP) in extremely low birth weight (ELBW) Chinese infants. A retrospective medical record review of all ELBW (≤1,000 g) neonates screened for ROP from 2007 to 2012 was performed in Hong Kong. ROP screening was conducted at 2 neonatal intensive care units by 3 pediatric ophthalmologists using the Royal College of Ophthalmologists ROP guideline and the International Classification of ROP. Maternal and neonatal covariates were analyzed using univariate and multivariate regression analyses for both ROP and Type 1 ROP. In 131 ELBW Chinese infants, the mean gestational age (GA) and birth weight (BW) were 27.3 ± 3.3 weeks and 806.9 ± 133.7 g, respectively. The incidence of ROP and Type 1 ROP was 53.4 and 14.5 %, respectively. For ROP, a lighter BW, smaller GA, vaginal delivery, postnatal hypotension, inotrope use, bronchopulmonary dysplasia, surfactant use, invasive mechanical ventilation, and supplementary oxygen were independent risk factors for ROP, while PET was protective (P ≤ 0.02). On multivariate analysis, a smaller GA was a risk factor, while PET and congenital heart disease were protective for ROP development (P ≤ 0.01). For Type 1 ROP, a lighter BW, smaller GA, surfactant use, and invasive mechanical ventilation were independent risk factors for ROP, while PET was protective (P ≤ 0.02). There were no significant covariates on multivariate analysis for Type 1 ROP. In ELBW, preterm Chinese infants, a smaller GA was a risk factor for ROP, while PET and congenital heart disease were protective for ROP development in multivariate analysis.

Keywords

Retinopathy of prematurity ROP Extreme low birth weight Chinese Risk factors 

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Gordon S. K. Yau
    • 1
  • Jacky W. Y. Lee
    • 1
  • Victor T. Y. Tam
    • 1
  • Catherine C. L. Liu
    • 2
  • Benjamin C. Y. Chu
    • 1
  • Can Y. F. Yuen
    • 1
  1. 1.The Department of OphthalmologyCaritas Medical CentreKowloonPeople’s Republic of China
  2. 2.Department of Applied MathematicsThe Hong Kong Polytechnic UniversityKowloonPeople’s Republic of China

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