International Ophthalmology

, Volume 35, Issue 1, pp 115–120 | Cite as

Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice

  • Emrah KanEmail author
  • Elif Kiliçkan
  • Ahmet Ayar
  • Ramis Çolak
Original Paper


The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model. Twenty-eight male BALB/C mice were made diabetic by the intraperitoneal administration of streptozotocin (200 mg/kg). Three weeks after induction of diabetes, mice were divided randomly into 4 groups in which each group contained 7 mice; fisetin-treated group (group 1), α-lipoic acid-treated group (group 2), fisetin placebo group (group 3), α-lipoic acid placebo group (group 4). Fisetin and α-lipoic acid were administered intraperitoneally weekly for 5 weeks. Cataract development was assessed at the end of 8 weeks by slit lamp examination, and cataract formation was graded using a scale. All groups developed at least grade 1 cataract formation. In the fisetin-treated group, the cataract stages were significantly lower than in the placebo group (p = 0.02). In the α-lipoic acid-treated group, the cataract stages were lower than in the placebo group but it did not reach to a significant value. Both fisetin and α-lipoic acid had a protective effect on cataract development in a streptozotocin-induced experimental cataract model. The protective effect of fisetin appears as though more effective than α-lipoic acid.


α-Lipoic acid Antioxidants Diabetic cataract Experimental cataract Fisetin 


Conflict of interest

The authors have no conflict of interest.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Emrah Kan
    • 1
    Email author
  • Elif Kiliçkan
    • 2
  • Ahmet Ayar
    • 3
  • Ramis Çolak
    • 4
  1. 1.Department of OphthalmologySamsun Training and Research HospitalSamsunTurkey
  2. 2.Department of Endocrinology and MetabolismSamsun Training and Research HospitalSamsunTurkey
  3. 3.Department of Physiology, Faculty of MedicineKaradeniz Technical UniversityTrabzonTurkey
  4. 4.Department of Endocrinology and Metabolism, Faculty of MedicineOndokuz Mayıs UniversitySamsunTurkey

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