International Ophthalmology

, Volume 34, Issue 4, pp 809–815 | Cite as

Central corneal thickness in southern Egypt

Original Paper

Abstract

The study aimed to determine mean central corneal thickness (CCT) in a southern Egyptian population according to gender and age using ultrasonic pachymetry and to compare these CCT measurements to different populations. A prospective, observational, consecutive case series of 4,368 non-glaucomatous subjects (emmetropes and myopes) aged 16–70 years was carried out from August 2010 to March 2013 at the outpatient ophthalmology clinic in Sohag University Hospital and the Laser Vision Center in Sohag City, Egypt. Refraction, keratometry, slit-lamp examination, and intraocular pressure (IOP) measurements were obtained for all subjects. CCT was measured by ultrasonic pachymetry. The average CCT was 530.06 ± 38.03 μm. Average CCT was 532.6 ± 33.3 μm in emmetropes, 531.5 ± 31.3 μm in myopes <6 diopters (D), 531.1 ± 31.4 μm in myopes >6 D and 533 ± 33 μm in hyperopes, with no statistically significant difference between the groups. There was a statistically significant difference in CCT between age groups and gender. There was a strong correlation between CCT and IOP among the non-glaucomatous population. CCT was found to be lower in Egyptians than in Caucasian, Hispanic, and Japanese populations but comparable to African and African American populations.

Keywords

Central corneal thickness Ultrasonic pachymetry Egypt Ethnicity 

Notes

Acknowledgments

I would like to extend my thanks to my assisting nursing staff that helped with collecting and organizing patient data.

Conflict of interest

The author declares no conflict of interest in this paper.

References

  1. 1.
    Thomas Ho, Cheng ACK, Srinivas K et al (2007) Central corneal thickness measurements using Orbscan II, Visante, ultrasound, and Pentacam pachymetry after laser in situ keratomileusis for myopia. J Cataract Refract Surg 33:1177–1182CrossRefGoogle Scholar
  2. 2.
    Shih CY, Graff Zivin JS, Trokel SL et al (2004) Clinical significance of central corneal thickness in the management of glaucoma. Arch Ophthalmol 122:1270–1275PubMedCrossRefGoogle Scholar
  3. 3.
    Gordon MO, Beiser JA, Brandt JD et al (2002) The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 120:714–720PubMedCrossRefGoogle Scholar
  4. 4.
    Hong S, Kim CY, Seong GJ et al (2007) Central corneal thickness and visual field progression in patients with chronic primary angle-closure glaucoma with low intraocular pressure. Am J Ophthalmol 143:362–363PubMedCrossRefGoogle Scholar
  5. 5.
    Miglior S, Pfeiffer N, Torri V et al (2007) Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study. Ophthalmology 114:3–9PubMedCrossRefGoogle Scholar
  6. 6.
    Rapuano CJ, Fishbaugh JA, Strike DJ (1993) Nine point corneal thickness measurements and keratometry readings in normal corneas using ultrasound pachymetry. Insight 18:16–22PubMedGoogle Scholar
  7. 7.
    La Rosa FA, Gross RL, Orengo-Nania S (2001) Central corneal thickness of Caucasians and African Americans in glaucomatous and nonglaucomatous populations. Arch Ophthalmol 119:23–27PubMedGoogle Scholar
  8. 8.
    Brandt JD, Beiser JA, Kass MA, Gordon MO (2001) Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS). Ophthalmology 108:1779–1788PubMedCrossRefGoogle Scholar
  9. 9.
    Shimmyo M, Ross AJ, Moy A, Mostafavi R (2003) Intraocular pressure, Goldmann applanation tension, corneal thickness, and corneal curvature in Caucasians, Asians, Hispanics, and African Americans. Am J Ophthalmol 136:603–613PubMedCrossRefGoogle Scholar
  10. 10.
    Nemesure B, Wu SY, Hennis A, Leske MC, Barbados Eye Study Group (2003) Corneal thickness and intraocular pressure in the Barbados Eye Studies. Arch Ophthalmol 121:240–244PubMedCrossRefGoogle Scholar
  11. 11.
    Hahn S, Azen S, Ying-Lai M, Varma R, Los Angeles Latino Eye Study Group (2003) Central corneal thickness in Latinos. Invest Ophthalmol Vis Sci 44:1508–1512PubMedCrossRefGoogle Scholar
  12. 12.
    Alsbirk PH (1978) Corneal thickness. I. Age variation, sex difference and oculometric correlations. Acta Ophthalmol (Copenh) 56:95–104CrossRefGoogle Scholar
  13. 13.
    Wong ACM, Wong CC, Yuen NSY, Hui SP (2002) Correlational study of central corneal thickness measurements on Hong Kong Chinese using optical coherence, Orbscan and ultrasound pachymetry. Eye 16:715–721PubMedCrossRefGoogle Scholar
  14. 14.
    Cho P, Lam C (1999) Factors affecting the central corneal thickness of Hong Kong-Chinese. Curr Eye Res 18:368–374PubMedCrossRefGoogle Scholar
  15. 15.
    Lam AK, Douthwaite WA (1998) The corneal-thickness profile in Hong Kong Chinese. Cornea 17:384–388PubMedCrossRefGoogle Scholar
  16. 16.
    Lam AK, Douthwaite WA (1997) The effect of an artificially elevated intraocular pressure on corneal thickness in Chinese eye. Ophthalmic Physiol Opt 17:414–420PubMedCrossRefGoogle Scholar
  17. 17.
    Kang SW, Chung ES, Kim WJ (2000) Clinical analysis of central islands after laser in situ keratomileusis. J Cataract Refract Surg 26:536–542PubMedCrossRefGoogle Scholar
  18. 18.
    Wu LL, Suzuki Y, Ideta R, Araie M (2000) Central corneal thickness of normal tension glaucoma patients in Japan. Jpn J Ophthalmol 44:643–647PubMedCrossRefGoogle Scholar
  19. 19.
    Foster PJ, Wong JS, Wong E, Chen FG, Machin D, Chew PT (2000) Accuracy of clinical estimates of intraocular pressure in Chinese eyes. Ophthalmology 107:1816–1821PubMedCrossRefGoogle Scholar
  20. 20.
    Foster PJ, Baasanhu J, Alsbirk PH, Munkhbayar D, Uranchimeg D, Johnson GJ (1998) Central corneal thickness and intraocular pressure in a Mongolian population. Ophthalmology 105:969–973PubMedCrossRefGoogle Scholar
  21. 21.
    Copt RP, Thomas R, Mermoud A (1980) Corneal thickness in ocular hypertension, primary open-angle glaucoma, and normal tension glaucoma. Arch Ophthalmol 117:14–16CrossRefGoogle Scholar
  22. 22.
    Bechmann M, Thiel MJ, Neubauer AS, Ullrich S, Ludwig K, Kenyon KR et al (2001) Central corneal thickness measurement with a retinal optical coherence tomography device versus standard ultrasonic pachymetry. Cornea 20:50–54PubMedCrossRefGoogle Scholar
  23. 23.
    Wirbelauer C, Sholz C, Hoerauf H, Engelhardt R, Birngruber R, Laqua H (2000) Corneal optical coherence tomography before and immediately after excimer laser photorefractive keratectomy. Am J Ophthalmol 130:693–699PubMedCrossRefGoogle Scholar
  24. 24.
    Maldonado MJ, Ruiz-Oblitas L, Munuera JM (2000) Optical coherence tomography evaluation of the corneal cap and stromal bed features after laser in situ keratomileusis for high myopia and astigmatism. Ophthalmology 107:81–87 discussion 88PubMedCrossRefGoogle Scholar
  25. 25.
    Olsen T, Ehlers N (1984) The thickness of the human cornea as determined by a specular method. Acta Ophthalmol (Copenh) 62:859–871CrossRefGoogle Scholar
  26. 26.
    Nissen J, Hjortdal JO, Ehlers N, Frost-Larsen K, Sorensen T (1991) A clinical comparison of optical and ultrasonic pachometry. Acta Ophthalmol (Copenh) 69:659–663CrossRefGoogle Scholar
  27. 27.
    Wolfs RC, Klaver CC, Vingerling JR, Grobbee DE, Hofman A, de Jong PT (1997) Distribution of central corneal thickness and its association with intraocular pressure: the Rotterdam Study. Am J Ophthalmol 123:767–772PubMedGoogle Scholar
  28. 28.
    Ustundag C, Bahcecioglu H, Ozdamar A, Aras C, Yildirim R, Ozkan S (2000) Optical coherence tomography for evaluation of anatomical changes in the cornea after laser in situ keratomileusis. J Cataract Refract Surg 26:1458–1462PubMedCrossRefGoogle Scholar
  29. 29.
    Dohadwala AA, Munger R, Damji KF (1998) Positive correlation between Tono-Pen intraocular pressure and central corneal thickness. Ophthalmology 105:1849–1854PubMedCrossRefGoogle Scholar
  30. 30.
    Herse P, Yao W (1993) Variation of corneal thickness with age in young New Zealanders. Acta Ophthalmol (Copenh) 71:360–364CrossRefGoogle Scholar
  31. 31.
    Thomas R, Korah S, Muliyil J (2000) The role of central corneal thickness in the diagnosis of glaucoma. Indian J Ophthalmol 48:107–111PubMedGoogle Scholar
  32. 32.
    Kunert KS, Bhartiya P, Tandon R, Dada T, Christian H, Vajpayee RB (2003) Central corneal thickness in Indian patients undergoing LASIK for myopia. J Refract Surg 19:378–379PubMedGoogle Scholar
  33. 33.
    Dimasi D, Burdon K, Craig J (2010) The genetics of central corneal thickness. Br J Ophthalmol 94:971–976PubMedCrossRefGoogle Scholar
  34. 34.
    Forsius H, Maertens K, Fellman J (1995) Change of the eye caused by the climate in Rwanda, Africa. Ophthalmic Epidemiol 2:107–113PubMedCrossRefGoogle Scholar
  35. 35.
    Doughty MJ, Zaman ML (2000) Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol 44:367–408PubMedCrossRefGoogle Scholar
  36. 36.
    Mohamed NY, Hassan MN, Ali NA et al (2009) Central corneal thickness in Sudanese population. Sud J Ophthalmol 1(1):29–32Google Scholar
  37. 37.
    Eballe AO, Koki G, Ellong A et al (2010) Central corneal thickness and intraocular pressure in the Cameroonian nonglaucomatous population. Clin Ophthalmol 4:717–724PubMedCentralPubMedCrossRefGoogle Scholar
  38. 38.
    Eballe AO, Epée E, Koki G et al (2010) Analysis of central corneal thickness in black Cameroonian children. Clin Optom 2:113–117CrossRefGoogle Scholar
  39. 39.
    Gelaw Y, Kollmann M, Irungu NM et al (2010) The influence of central corneal thickness on intraocular pressure measured by goldmann applanation tonometry among selected Ethiopian communities. J Glaucoma 19(8):514–518PubMedCrossRefGoogle Scholar
  40. 40.
    Kim HY, Budenz DL, Lee PS et al (2008) Comparison of central corneal thickness using anterior segment optical coherence tomography vs ultrasound pachymetry. Am J Ophthalmol 145:228–232PubMedCrossRefGoogle Scholar
  41. 41.
    Iyamu E, Ituah I (2008) The relationship between central corneal thickness and intraocular pressure: a comparative study of normals and glaucoma subjects. Afr J Med Med Sci 37:345–353PubMedGoogle Scholar
  42. 42.
    Mercieca K, Odogu V, Fiebai B et al (2007) Comparing central corneal thickness in a sub-Saharan cohort to African Americans and Afro-Caribbeans. Cornea 26:557–560PubMedGoogle Scholar
  43. 43.
    Babalola OE, Kehinde AV, Iloegbunam AC et al (2009) A comparison of Goldmann applanation and non-contact (Keeler Pulsair EasyEye) tonometers and the effect of central corneal thickness in indigenous African Eyes. Ophthal Physiol Opt 29:182–186CrossRefGoogle Scholar
  44. 44.
    Iyamu E, Kio F, Idu FK et al (2010) The relationship between central corneal thickness and intraocular pressure in adult Nigerians without glaucoma. Sierra Leone J Biomed Res 2:95–102Google Scholar
  45. 45.
    Iyamu E, Osuobeni E (2012) Age, gender, corneal diameter, corneal curvature and central corneal thickness in Nige-rians with normal intraocular pressure. J Optom 5:87–97PubMedCentralCrossRefGoogle Scholar
  46. 46.
    Iyamua E, Iyamub JE, Amadasun G (2013) Central corneal thickness and axial length in an adult Nigerian population. J Optom 6(3):154–160CrossRefGoogle Scholar
  47. 47.
    Lazreg S, Mesplié N, Praud D et al (2013) Comparison of corneal thickness and biomechanical properties between North African and French patients. J Cataract Refract Surg 39(3):425–430PubMedCrossRefGoogle Scholar
  48. 48.
    Mbumba BF, Kagame K, Onyango J et al (2012) Characteristics of glaucoma in black African patients attending Ruharo eye center, South Western Uganda. East Afr J Ophthalmol 16:21–24Google Scholar
  49. 49.
    Sardiwalla Z, Moodley D, Ndawonde T et al (2012) A comparative study of central corneal thickness (CCT) and intraocular pressure (IOP) in University of KwaZulu-Natal students of Black and Indian ethnicity. South Afr Optom 71(4):171–177Google Scholar
  50. 50.
    Su DHW, Wong TY, Foster PJ et al (2009) Central corneal thickness and its associations with ocular and systemic factors: the Singapore Malay eye study. Am J Ophthalmol 147:709–716PubMedCrossRefGoogle Scholar
  51. 51.
    Tong L, Saw SM, Siak JK et al (2004) Corneal thickness determination and correlates in Singaporean schoolchildren. Invest Ophthalmol Vis Sci 45:4004–4009PubMedCrossRefGoogle Scholar
  52. 52.
    Foster PJ, Machin D, Wong TY et al (2003) Determinants of intraocular pressure and its association with glaucomatous optic neuropathy in Chinese Singaporeans: the Tanjong Pagar Study. Invest Ophthalmol Vis Sci 44:3885–3891PubMedCrossRefGoogle Scholar
  53. 53.
    Fam HB, How AC, Baskaran M et al (2006) Central corneal thickness and its relationship to myopia in Chinese adults. Br J Ophthalmol 90:1451–1453PubMedCentralPubMedCrossRefGoogle Scholar
  54. 54.
    Lifshitz T, Levy J, Rosen S et al (2006) Central corneal thickness and its relationship to the patient’s origin. Eye 20:460–465PubMedCrossRefGoogle Scholar
  55. 55.
    Toh T, Liew SH, MacKinnon JR et al (2005) Central corneal thickness is highly heritable: the twin eye studies. Invest Ophthalmol Vis Sci 46:3718–3722PubMedCrossRefGoogle Scholar
  56. 56.
    Zheng Y, Ge J, Huang G et al (2008) Heritability of central corneal thickness in Chinese: the Guangzhou Twin Eye Study. Invest Ophthalmol Vis Sci 49:4303–4307PubMedCrossRefGoogle Scholar
  57. 57.
    Landers JA, Hewitt AW, Dimasi DP et al (2009) Heritability of central corneal thickness in nuclear families. Invest Ophthalmol Vis Sci 50:4087–4090PubMedCrossRefGoogle Scholar
  58. 58.
    George R, Baskaran M et al (2008) Prevalence of primary open-angle glaucoma in an urban south Indian population and comparison with a rural population. The Chennai Glaucoma Study. Ophthalmology 115(4):648–654PubMedCrossRefGoogle Scholar
  59. 59.
    Tomidokoro A, Araie M, Iwase A (2007) Corneal thickness and relating factors in a population-based study in Japan: the Tajimi Study. Am J Ophthalmol 144:152–154PubMedCrossRefGoogle Scholar
  60. 60.
    Suzuki S, Suzuki Y, Iwase A et al (2005) Corneal thickness in an ophthalmologically normal Japanese population. Ophthalmology 112:1327–1336PubMedCrossRefGoogle Scholar
  61. 61.
    Zhang H, Xu L, Chen C et al (2008) Central corneal thickness in adult Chinese. Association with ocular and general parameters. The Beijing Eye Study. Graefes Arch Clin Exp Ophthalmol 246:587–592PubMedCrossRefGoogle Scholar
  62. 62.
    Casson RJ, Abraham LM, Newland HS et al (2008) Corneal thickness and intraocular pressure in a nonglaucomatous Burmese Population. The Meiktila Eye Study. Arch Ophthalmol 126:981–985PubMedCrossRefGoogle Scholar
  63. 63.
    Hansen FK (1971) A clinical study of the normal human central corneal thickness. Acta Ophthalmol (Copenh) 49:82–89Google Scholar
  64. 64.
    Korey M, Gieser D, Kass MA et al (1982) Central corneal endothelial cell density and central corneal thicknessin ocular hypertension and primary open angle glaucoma. Am J Ophthalmol 94:610–616PubMedGoogle Scholar
  65. 65.
    Aghaian E, Choe JE, Lin S et al (2004) Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic. Ophthalmology 111:2211–2219PubMedCrossRefGoogle Scholar
  66. 66.
    Torres RJ, Jones E, Edmunds B et al (2008) Central corneal thickness in Northwestern American Indians/Alaskan Natives and comparison with white and African–American persons. Am J Ophthalmol 146:747–751PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of OphthalmologySohag UniversitySohagEgypt

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