International Ophthalmology

, Volume 34, Issue 2, pp 301–303 | Cite as

Incomplete Gardner’s syndrome with blepharoptosis as the first symptom

  • Irini P. Chatziralli
  • Leonidas Papazisis
  • Theodoros N. Sergentanis
Case Report


Gardner’s syndrome (GS) is an autosomal dominant form of polyposis characterized by the presence of multiple polyps in the colon together with osseous tumors and soft-tissue tumors, such as epidermoid cysts and lipomas. An osteoma is a benign, osteogenic tumor and may be sporadic or related to GS. Here, we present a patient with a giant sino-orbital osteoma and blepharoptosis as the only symptom of incomplete GS. A 74-year-old woman, with no previous history of trauma or ophthalmic surgery, presented with a 2 years history of right blepharoptosis without diplopia. The results of slit-lamp and fundoscopic examination were normal. Computed tomography showed a giant sino-orbital osteoma. With suspicion for GS, we thoroughly examined the patient and found no soft-tissue tumors. Fifteen years ago, the patient, who had a family history of colonic polyposis, underwent right colectomy and chemotherapy for adenocarcinoma. We report a case of incomplete GS with blepharoptosis as the first symptom.


Blepharoptosis Osteoma Gardner syndrome Sino-orbital 


  1. 1.
    Oku T, Takayama T, Sato Y, Sato Y, Takada K, Hayashi T, Takahashi M, Kuroda M, Kato J, Niitsu Y (2004) A case of Gardner syndrome with a mutation at codon 1556 of APC: a suggested case of genotype-phenotype correlation in dental abnormality. Eur J Gastroenterol Hepatol 16:101–105PubMedCrossRefGoogle Scholar
  2. 2.
    McHugh JB, Mukherji SK, Lucas DR (2009) Sino-orbital osteoma: a clinicopathologic study of 45 surgically treated cases with emphasis on tumors with osteoblastoma-like features. Arch Pathol Lab Med 133:1587–1593PubMedGoogle Scholar
  3. 3.
    Gossios K, Bai M, Psilas K (1999) Giant aggressive osteoma of the frontal sinus. Clin Radiol 54:193–196PubMedCrossRefGoogle Scholar
  4. 4.
    Kim AW, Foster JA, Papay FA, Wright KW (2000) Orbital extension of a frontal sinus osteoma in a thirteen-year-old girl. J AAPOS 4:122–124PubMedCrossRefGoogle Scholar
  5. 5.
    Herford AS, Stoffella E, Tandon R (2013) Osteomas involving the facial skeleton: a report of 2 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol 115:e1–e6PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Irini P. Chatziralli
    • 1
    • 3
  • Leonidas Papazisis
    • 1
  • Theodoros N. Sergentanis
    • 2
  1. 1.Department of OphthalmologyVeroia General HospitalVeroiaGreece
  2. 2.School of MedicineNational University of AthensAthensGreece
  3. 3.AthensGreece

Personalised recommendations