International Ophthalmology

, Volume 31, Issue 6, pp 513–515 | Cite as

Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultraviolet-A for progressive keratoconus

  • Nilay YukselEmail author
  • Kamil Bilgihan
  • Ahmet M. Hondur
Case Report


To describe a case of herpetic keratitis after corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A for progressive keratoconus. A 31-year-old woman with rapidly progressive keratoconus in the left eye was treated with CXL. Four days postoperatively, a dendritic ulcer developed in the treated eye. The diagnosis was confirmed with polymerase chain reaction analysis of the corneal swab for herpes simplex. The patient had no prior history of herpetic eye disease or cold sores. The keratitis resolved in 10 days with treatment. At 1 month, the visual acuity was stable, but a mild superficial opacity was noted. Herpetic keratitis can be induced by CXL even in patients with no history of previous herpetic eye disease. Early diagnosis and proper treatment can facilitate successful management of this rare but important complication.


Cornea Cross linking Herpes simplex Keratoconus Polymerase chain reaction 



None of the authors has a financial support or proprietary interest in any method or material mentioned.


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Nilay Yuksel
    • 1
    Email author
  • Kamil Bilgihan
    • 2
  • Ahmet M. Hondur
    • 2
  1. 1.Department of OphthalmologyKahramanmaras State HospitalKahramanmarasTurkey
  2. 2.Department of OphthalmologyGazi University Medical SchoolAnkaraTurkey

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