International Ophthalmology

, Volume 30, Issue 2, pp 183–189

Immune recovery uveitis associated with highly active antiretroviral therapy in a patient with CMV retinitis and AIDS despite a low CD4+ T cell count: case report and a review of the literature

Original Paper

DOI: 10.1007/s10792-009-9303-1

Cite this article as:
Alp, M.N., Baykam, N. & Kural, G. Int Ophthalmol (2010) 30: 183. doi:10.1007/s10792-009-9303-1


An unusual case of CMV retinitis and AIDS who developed immune recovery uveitis (IRU) despite a low CD4+ T cell count achieved during HAART is reported. A 36-year-old female complained of blurred vision in both eyes six months after initiation of anti-CMV retinitis therapy and HAART. Ocular examination revealed a substantial intraocular inflammation causing a dense vitreous haze and frosted branch angiitis. Consecutive CD4+ T cell counts were 20 cells/mm3 or less and plasma HIV mRNA was undetectable. The laboratory test for Cytomegalovirus was positive whereas those for infections known to cause uveitis were negative. The inflammatory reaction resolved with treatment, but she developed retinal detachment just before she died of pulmonary complications. A review of the literature led us to propose that our patient developed an intraocular inflammation which may probably be a form of IRU and it might be appropriate to employ additional criteria in the definition and the diagnosis of IRU.


AIDS Cytomegalovirus retinitis Highly active antiretroviral therapy Immune recovery uveitis 

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Mehmet Numan Alp
    • 1
  • Nurcan Baykam
    • 2
  • Gulcan Kural
    • 1
  1. 1.Department of OphthalmologyNumune Training and Research HospitalAnkaraTurkey
  2. 2.Department of Infectious Diseases and Clinical MicrobiologyNumune Training and Research HospitalAnkaraTurkey

Personalised recommendations