International Ophthalmology

, Volume 29, Issue 3, pp 127–133 | Cite as

Long-term control of cystoid macular oedema in noninfectious uveitis with Mycophenolate Mofetil

  • Piergiorgio Neri
  • Cesare Mariotti
  • Luca Cimino
  • Lucia Mercanti
  • Alfonso Giovannini
Original Paper


Purpose To evaluate the long-term safety and efficacy of Mycophenolate Mofetil (MMF) for the control of cystoid macular oedema (CMO) secondary to noninfectious uveitis (NU). Methods The medical records of 19 consecutive patients with inflammatory CMO treated with MMF were retrospectively reviewed. Patient demographics, best corrected visual acuity (BCVA), fluorescein angiography (FA), and optical coherence tomography (OCT) findings were evaluated. Results There were eight females and 11 males with a mean age of 32.9 ± 8.9 years. After a 1-year follow-up, 18/19 patients (31 eyes, 96.9%, P < 0.05) no longer had signs of CMO, as per their FA and OCT findings; the mean central foveal thickness (CFT) was 167.2 ± 12.8 μm. At the last follow-up, only 3/19 patients, all affected by Behçet panuveitis, had recurrences of CMO. Mean BCVA improved from 0.34 ± 0.14 SD at baseline to 0.65 ± 0.2 SD at last follow-up. Conclusions MMF was safe and effective in controlling CMO and in reducing the uveitis relapse rate in patients not responding to traditional immunosuppressants. Further case–controlled studies are mandatory to validate those preliminary results.


Cystoid macular oedema Immunosuppression Mycophenolate Mofetil Uveitis 





Behçet panuveitis




Cyclosporine A


Idiopathic intermediate uveitis


Idiopathic retinal vasculitis


Intravitreal triamcinolone


Sub-Tenon triamcinolone


Multifocal choroiditis with panuveitis


Mycophenolate mofetil




Ankylosing spondylitis associated uveitis


Previous immunosuppressive agents




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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Piergiorgio Neri
    • 1
    • 2
  • Cesare Mariotti
    • 1
    • 2
  • Luca Cimino
    • 3
  • Lucia Mercanti
    • 1
    • 2
  • Alfonso Giovannini
    • 1
    • 2
  1. 1.Neuroscience Department, Ophthalmology SectionPolytechnic University of MarcheAnconaItaly
  2. 2.The Eye ClinicAzienda Ospedaliero-Universitaria, “Ospedali Riuniti”AnconaItaly
  3. 3.Ocular Immunology UnitArcispedale S.M. NuovaReggio EmiliaItaly

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