International Ophthalmology

, Volume 27, Issue 4, pp 241–250 | Cite as

Biopsy techniques and yields in diagnosing primary intraocular lymphoma

Original Paper


A review of current biopsy techniques that are used in obtaining specimens from which to make a diagnosis of primary intraocular lymphoma (PIOL) is presented. Methods for obtaining and subsequently testing vitrectomy specimens are discussed. In addition, the yields of external and internal approaches for obtaining chorioretinal tissue, and diagnostic vitrectomies, are reviewed.


Primary intraocular lymphoma Vitrectomy Chorioretinal biopsy Transvitreal retinal biopsy 



cerebrospinal fluid


primary central nervous system lymphoma


primary intraocular lymphoma


polymerase chain reaction amplification.


retinal pigment epithelium


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  1. 1.Immunopathology Section, Laboratory of ImmunologyNational Eye Institute, National Institutes of HealthBethesdaUSA
  2. 2.Howard Hughes Medical InstituteChevy ChaseUSA
  3. 3.Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA

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