Pathology of Vogt–Koyanagi–Harada disease
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Typical histopathologic features of Vogt–Koyanagi–Harada disease (VKH) include granulomatous panuveitis with preservation of the choriocapillaris and exudative retinal detachment. In the chronic stage of the disease, however, histologic changes consist of nongranulomatous uveitis followed, in the chronic recurrent stage, by granulomatous uveitis and involvement of the choriocapillaris. In chronic VKH the peripheral fundus scars are not Dalén–Fuchs nodules; they are, instead, indicative of focal chorioretinal atrophy with loss of retinal pigment epithelium.
KeywordsGranulomatous uveitis Vogt–Koyanagi–Harada disease Sympathetic ophthalmia Pathology Choriocapillaris
Supported in part by NEI core grant EY0 13040 and by a grant from Research to Prevent Blindness, New York, New York.