Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo
- 155 Downloads
Objective and Design
The objective of this study was to investigate the leucocyte-related antiinflammatory properties of rose hip. Materials and Methods: The effect of rose hip on a number of inflammatory parameters was evaluated using the following models: (1) The effect of rose hip extract on chemotaxis and chemiluminescence of peripheral blood polymorphonuclear leucocytes (PMNs) from healthy subjects in vitro; (2) The effect of rose hip administered to healthy subjects on serum levels of creatinine and C-reactive protein and on chemotaxis and chemiluminescence of peripheral blood PMNs. Results: Rose hip extract at concentrations higher than 500 μg/m1 inhibited the chemotaxis and chemiluminescence of peripheral blood polymorphonuclear leucocytes in vitro. Daily intake of rose hip powder at doses of 45 grams or lower by healthy subjects resulted in reduced chemotaxis of peripheral blood PMNs and reduced the level of serum creatinine and acute phase protein CRP.
These results indicate that rose hip possesses antiinflammatory properties and might be used as a replacement or supplement for conventional drug therapies in some inflammatory diseases such as arthritis.
Key wordsRose hip Rosa canina neutrophil chemotaxis CRP antiinflammatory
Unable to display preview. Download preview PDF.
- Harris, Jr., E. D. (1988). Pathogenesis of rheumatoid arthritis: A disorder associated with dysfunc- tional immunoregulation. In: Inflammation. Basic Principles and Clinical Correlates, Gallin, J. H., Goldstein, I. M. and Snyderman, R. (Eds), pp. 751–773. Raven Press, New York.Google Scholar
- Kharazmi, A., Høiby, N., Döring, G. and Valerius, N. H. (1986). Pseudomonas aeruginosa exopro- teases inhibit human neutrophil chemiluminescence, Infect. Immun. 44, 587–591.Google Scholar
- Winther, K., Rein, E. and Kharazmi, A. (1999). The anti-inflammatory properties of rose-hip, Inflammopharmacol. 7, 63–68.Google Scholar