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InflammoPharmacology

, Volume 7, Issue 3, pp 303–310 | Cite as

Concerning the anti-arthritic action of cetyl myristoleate in rats: An interim report

  • M. W. Whitehouse
  • R. P. McGeary
Article

Abstract

The proposed arthro-preventive action of cetyl myristoleate, an OTC product sold as a nutritional supplement, could not be confirmed, using an almost identical bioassay (adjuvant-induced polyarthritis in rats) as that described in the original report (Diehl and May, 1994) with the same, and 3 other, dosing schedules.

Key words

Arthritis prevention Cetyl myristoleate Cyclosporin Lyprinol 

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References

  1. Diehl, H. W. (1977). Cetyl myristoleate, US patent 4,049,824.Google Scholar
  2. Diehl, H. W. (1996). Method for the treatment of osteoarthritis, US patent 5,569,676.Google Scholar
  3. Diehl, H. W. and May, E. L. (1994). Cetyl myristoleate isolated from Swiss albino mice: an apparent protective agent against adjuvant arthritis in rats. J. Pharm. Sci. 83, 296–299.PubMedCrossRefGoogle Scholar
  4. EHP (1997). Myristin dietary supplement. EHP Products (Ashland, Kentucky). Web page (updated Jan 21,1997).Google Scholar
  5. Haynes, D. R., Gadd, S. J., Whitehouse, M. W., Mayrhofer, G. and Vernon-Roberts, B. (1996). Complete prevention of the clinical expression of adjuvant-induced arthritis in rats by cyclosporin-A and lobenzarit: the regulation of lymph node cell populations and cytokine production, Inflamm. Res. 45, 159–165.PubMedCrossRefGoogle Scholar
  6. Whitehouse, M. W., Macrides, T. A., Kalafatis, N., Betts, W. H., Haynes, D. R. and Broadbent, J. (1997). Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel, Inflammopharmacology 5, 237–246.Google Scholar

Copyright information

© VSP 1999

Authors and Affiliations

  • M. W. Whitehouse
    • 1
  • R. P. McGeary
    • 2
  1. 1.Department of MedicineUniversity of QueenslandBrisbaneAustralia
  2. 2.Centre for Drug Design & DevelopmentUniversity of QueenslandBrisbaneAustralia

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