, Volume 27, Issue 2, pp 213–231 | Cite as

Prevalence and current therapy in chronic liver disorders

  • Muhammad Daniyal
  • Muhammad Akram
  • Rida ZainabEmail author
  • Naveed Munir
  • Aamir Sharif
  • Syed Muhammad Ali Shah
  • Bin Liu
  • Wei Wang
Review Article



Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of medicinal plants was effective in the treatment of infectious and non-infectious diseases. Hepatitis and liver cirrhosis associated with many clinical manifestations can be treated with allopathic medicines, but reports of a number of side effects including immunosuppression, bone marrow suppression, and renal complications have motivated researchers to explore more natural herbal medicines with low or no side effects and with high efficacy in treating hepatic diseases.


Databases including PubMed, Medline, and Google Scholar were searched for findings on the hepatoprotective effects of plants.


Various medicinal plants are used for the treatment of liver disorders. The range of alternative therapies is huge, and they are used worldwide, either as part of primary health care or in combination with conventional medicine. Hepatoprotective plants contain a variety of chemical constituents including flavonoids, alkaloids, glycosides, carotenoids, coumarins, phenols, essential oil, organic acids, monoterpenes, xanthenes, lignans, and lipids.


This review shows that numerous plants are found to contain hepatoprotective compounds. However, further studies are needed to determine their association with existing regimes of antiviral medicines and to develop evidence-based alternative medicine to cure different kinds of liver disease in humans.


Liver disorders Allopathic medicine Side effects Medicinal plants Hepatoprotective activity Efficacy Literature review 



We are very thankful to Hunan Province Universities 2011 Collaborative Innovation Center of Protection and Utilization of Hu-xiang Chinese Medicine Resources, Hunan Provincial Key Laboratory of Diagnostics in Chinese Medicine, National Natural Science Foundation of China (81673579 and 81874369), Hunan Provincial Department of Science and Technology (2018SK2113), and the State Administration of TCM (ZYBZH-Y-HUN-23).


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Muhammad Daniyal
    • 1
  • Muhammad Akram
    • 2
  • Rida Zainab
    • 2
    Email author
  • Naveed Munir
    • 3
  • Aamir Sharif
    • 4
  • Syed Muhammad Ali Shah
    • 2
  • Bin Liu
    • 5
  • Wei Wang
    • 1
  1. 1.TCM and Ethnomedicine Innovation and Development International Laboratory, School of Pharmacy, Innovative Materia Medica Research InstituteHunan University of Chinese MedicineChangshaPeople’s Republic of China
  2. 2.Department of Eastern Medicine, Directorate of Medical SciencesGovernment College UniversityFaisalabadPakistan
  3. 3.Department of Biochemistry and College of Allied health professionals, Directorate of Medical sciencesGovernment College UniversityFaisalabadPakistan
  4. 4.Department of Pathology, Faculty of Medical and Health SciencesUniversity of SargodhaSargodhaPakistan
  5. 5.Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of BiologyHunan UniversityChangshaChina

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