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Inflammopharmacology

, Volume 26, Issue 1, pp 87–104 | Cite as

Anti-inflammatory effects of Ginkgo biloba extract against trimethyltin-induced hippocampal neuronal injury

  • Sukhwinder Kaur
  • Neha Sharma
  • Bimla NehruEmail author
Original Article

Abstract

Background

Despite the immense neuromodulatory potentials of Ginkgo biloba extract as a memory enhancer, its underlying mechanism seems inadequate particularly with regard to its anti-inflammatory properties.

Aim

The objective of the present study is to investigate the protective potentials of Ginkgo biloba extract (GBE) against hippocampal neuronal injury induced by trimethyltin (TMT), a potent neurotoxicant.

Methods

Male SD rats were administered trimethyltin (8.5 mg kg−1 b.wt) single intraperitoneal (i.p.) injection, followed by Ginkgo biloba extract (100 mg kg−1 b.wt i.p) for 21 days.

Results

The co-administration of GBE with TMT showed marked improvement in cognitive functions. Concomitantly, there was a significant decrease in oxidative stress as evident by reduction in MDA and total ROS levels. In addition, there was a marked suppression of astrocyte activation (GFAP), transcription factor NFκB and proinflammatory cytokines (TNF-α, IL-1α, 1L-6), which were found to be elevated by TMT administration. Histopathological observations showed remarkable improvement in hippocampal neuronal injury in the conjunctive group.

Conclusion

Therefore, it is suggested that Ginkgo biloba extract is an effective agent against trimethyltin-induced hippocampal neuronal loss owing to its antioxidative as well as anti-inflammatory properties.

Keywords

Ginkgo biloba extract Trimethyltin GFAP Neuroinflammation Proinflammatory Cytokines 

Abbreviations

5 HT

Serotonin

GBE

Ginkgo biloba extract

GFAP

Glial fibrillary acidic protein

GPx

Glutathione peroxidase

GSH

Reduced glutathione

i.p

Intraperitoneal

IL

Interleukins

iNOS

Inducible nitric oxide synthase

MDA

Malondialdehyde

NF-κB

Nuclear factor-κB

ROS

Reactive oxygen species

TMT

Trimethyltin

TNF-α

Tumor necrosis factor-α

Notes

Acknowledgements

The financial assistance to Dr. Sukhwinder Kaur in the form of junior research fellowship from the University Grant Commission is highly acknowledged.

Compliance with ethical standards

Conflict of interest

We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Biophysics, Basic Medical Sciences BlockPanjab UniversityChandigarhIndia

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