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Inflammopharmacology

, Volume 25, Issue 4, pp 403–413 | Cite as

Melatonin as an anti-inflammatory agent in radiotherapy

  • M. Najafi
  • A. ShiraziEmail author
  • E. MotevaseliEmail author
  • A. H. Rezaeyan
  • A. Salajegheh
  • S. Rezapoor
Review

Abstract

Radiotherapy is one of the most relevant treatment options for cancer therapy with or without other treatment modalities including immunotherapy, surgery and chemotherapy. Exposure to heavy doses of ionizing radiation during radiotherapy results in short and long term side effects. It appears that many of these side effects are linked to inflammatory responses during treatment or after prolonged use. Inflammation is mediated by various genes and cytokines related to immune system responses caused by massive cell death following radiotherapy. This phenomenon is more obvious, particularly after exposure to clinical doses of radiotherapy. Inflammation is involved in the amplification of acute responses, genomic instability and also long term pathological changes in normal tissues. Moreover, inflammation attenuates responses of the tumor to radiotherapy through some mechanisms such as angiogenesis. Thus, the management of inflammation is one of the most interesting aims in cancer radiotherapy. Melatonin, known as a natural product in the body, has been of much interest for its anti-inflammatory properties. Some studies have proposed melatonin as a novel anti-inflammation agent. This literature review will concentrate on the anti-inflammatory properties of melatonin that may help the management of different inflammatory signaling pathways in both tumor and normal tissues.

Keywords

Melatonin Inflammation Radiotherapy Oxidative stress Immune system 

Notes

Acknowledgement

Tehran University of Medical Sciences. Grant number 33480.

Compliance with ethical standards

Conflict of interest

None.

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Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  1. 1.Department of Medical Physics and Biomedical Engineering, Faculty of MedicineTehran University of Medical SciencesTehranIran
  2. 2.Department of Molecular Medicine, School of Advanced Technologies in MedicineTehran University of Medical SciencesTehranIran
  3. 3.Department of Medical Physics, Faculty of MedicineIran University of Medical SciencesTehranIran
  4. 4.Department of Radiology, Faculty of ParamedicalShiraz University of Medical SciencesShirazIran
  5. 5.Department of Radiology, Faculty of ParamedicalTehran University of Medical SciencesTehranIran

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