LPS and neuroinflammation: a matter of timing
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Lipopolysaccharide (LPS) administration has been repeatedly shown to elicit central inflammation, regardless of the route of administration. In a recent study, Tiwari et al. (Inflammopharmacology 10.1007/s10787-016-0274-3, 2016) dispute the potential of peripheral administration of LPS to induce neuroinflammation. Here, I summarise literature indicating that the neuroinflammatory effects of LPS are time dependent, and suggest that their findings can be explained by the time at which they chose to measure neuroinflammation.
KeywordsNeuroinflammation Lipopolysaccharide Time-dependent effects
- Bossù P, Cutuli D, Palladino I, Caporali P, Angelucci F, Laricchiuta D, Gelfo F, de Bartolo P, Caltagirone C, Petrosini L (2012) A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18. J Neuroinflamm 9:101CrossRefGoogle Scholar
- Fan L, Wang T, Chang L, Song Y, Wu Y, Ma D (2014) Systemic inflammation induces a profound long term brain cell injury in rats. Acta Neurobiol Exp 74:298–306Google Scholar