, Volume 24, Issue 5, pp 291–293 | Cite as

LPS and neuroinflammation: a matter of timing

  • Patricia C. LopesEmail author


Lipopolysaccharide (LPS) administration has been repeatedly shown to elicit central inflammation, regardless of the route of administration. In a recent study, Tiwari et al. (Inflammopharmacology  10.1007/s10787-016-0274-3, 2016) dispute the potential of peripheral administration of LPS to induce neuroinflammation. Here, I summarise literature indicating that the neuroinflammatory effects of LPS are time dependent, and suggest that their findings can be explained by the time at which they chose to measure neuroinflammation.


Neuroinflammation Lipopolysaccharide Time-dependent effects 


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Copyright information

© Springer International Publishing 2016

Authors and Affiliations

  1. 1.Department of Evolutionary Biology and Environmental StudiesUniversity of ZurichZurichSwitzerland

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