Inflammopharmacology

, Volume 23, Issue 4, pp 195–201 | Cite as

Evaluation of the protective effect of Pterocarpus marsupium on acetic acid-induced ulcerative colitis in rats

  • Merin Maria Mathew
  • Nguyen Vinh Han
  • A. Murugesan
  • E. Arun Raj
  • K. G. Prasanth
Research Article

Abstract

The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, each having six rats. PM extract 100 mg and 200 mg/kg was given orally to groups four and five, respectively, and standard drug sulfasalazine (100 mg/kg, p.o) to group three. Group two served as UC control animals, and group one control animals received vehicle for 7 days. UC was induced by administering AA (3 % v/v of 2 ml) to all the animals except group one. After 72 h, the animals were killed and the colon was dissected out for microscopic, clinical evaluation, histopathological study and biochemical estimation. PM (100 and 200 mg/kg)-treated group had significantly reduced colon inflammation and mucosal damage. The treatment also normalized the altered antioxidant enzyme levels (LPO, SOD and GSH). Histopathological studies support the effect. The protective effect of PM may be due to antiinflammatory and antioxidant properties.

Keywords

Acetic acid Ulcerative colitis Pterocarpus marsupium Mucosal damage 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical statement

All procedures performed in studies involving animals were in accordance with the ethical standards of the institution at which the studies were conducted.

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Copyright information

© Springer Basel 2015

Authors and Affiliations

  • Merin Maria Mathew
    • 1
  • Nguyen Vinh Han
    • 1
  • A. Murugesan
    • 1
  • E. Arun Raj
    • 1
  • K. G. Prasanth
    • 1
  1. 1.Department of PharmacologyPSG College of PharmacyCoimbatoreIndia

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