, Volume 21, Issue 2, pp 169–176 | Cite as

Caffeic acid phenethyl ester attenuates IgE-induced immediate allergic reaction

  • Manar A. Nader
Research Article


Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively reduced both histamine and serotonin (5-HT)-induced vascular permeability in rats. CAPE also reduced histamine and leukotrienes (LTs) release from isolated rat peritoneal mast cells. Moreover, CAPE suppressed contraction induced by histamine (3 × 10−8–3 × 10−5 M), 5-HT (3 × 10−9–10−6 M) and adenosine (3 × 10−8–10−5 M) in guinea pig tracheal zigzag. These findings provide evidence that CAPE may serve as an effective therapeutic agent for allergic diseases.


CAPE Allergy IgE Leukotrienes Histamine Mast cell 


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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  1. 1.Department of Pharmacology and Toxicology, Faculty of PharmacyMansoura UniversityMansouraEgypt

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