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Inflammopharmacology

, Volume 21, Issue 1, pp 31–35 | Cite as

Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucifera L.

  • Sagar NaskarEmail author
  • U. K. Mazumder
  • G. Pramanik
  • P. Saha
  • P. K. Haldar
  • M. Gupta
Research Article

Abstract

Cocos nucifera L. (family: arecaceae) is generally straight unbranched plant, traditionally cultivated for its fruit (coconut) in home gardens. In the present study, anti-inflammatory and antinociceptive (analgesic) activity of hydromethanol extract of Cocos nucifera L. (HECN) was evaluated in animal models. HECN showed significant (p < 0.05) and dosedependent anti-inflammatory activity in carrageenan induced paw oedema models of inflammation and the result was comparable with the standard drug diclofenac. In addition, the extract also showed highly significant (p < 0.01) antinociceptive activity. HECN treated group showed increase in the reaction time in hot plate method and decrease the writhing induced by acetic acid in mice when compared with control group animal. The anti-inflammatory and antinociceptive activity observed in the present study could be attributed largely to the presence of its antioxidant phytoconstituents such as flavonoid, saponin and polyphenols.

Keywords

Anti-inflammatory Antinociceptive Cocos nucifera L. Carrageenan Acetic acid 

Notes

Acknowledgments

The authors are grateful to the authority of Jadavpur University for the facilities provided to carry out the research work.

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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Sagar Naskar
    • 1
    Email author
  • U. K. Mazumder
    • 1
  • G. Pramanik
    • 1
  • P. Saha
    • 1
  • P. K. Haldar
    • 1
  • M. Gupta
    • 1
  1. 1.Department of Pharmaceutical TechnologyJadavpur UniversityKolkataIndia

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