Flavonoids in propolis acting on mast cell-mediated wound healing
- 266 Downloads
Barroso et al. have shown, on the latest issue of Inflammopharmacology, that the topical application of propolis on surgical wounds affected the number of mast cells recruited in these sites, and suggested two well-known anti-inflammatory components present in propolis, namely caffeic acid and artepillin C, as possible active molecules (Borrelli et al. 2002; Paulino et al. 2008). It is widely acknowledged that propolis down-regulates type I allergy and inflammation by affecting mast cells, but the effective components of propolis, which cause these effects, remain still unknown. Propolis components vary depending on the area from which they are collected, mainly because of the genetic variability among wild plants in different geographic regions: variability in phenolics composition may result in different biochemical property of the propolis, depending on the main component active in raw propolis or in its extracts. In Chinese propolis, chrysin, kaempferol and its...
KeywordsMast Cell Genistein Propolis Caffeic Acid Phenethyl Ester Chrysin
Conflict of interest
The author declares that he has no conflict of interest.
- Barroso PR, Lopes-Rocha R, Pereira EMF, Marinho MA, De Miranda JL, Lima NL, Verli FD (2011) Effect of propolis on mast cells in wound healing. Inflammopharmacology. doi: 10.1007/s10787-011-0105-5
- Burnstock G, Knight GE, Greig AV (2011) Purinergic signaling in healthy and diseased skin. J Invest Dermatol. doi: 10.1038/jid.2011.344
- Frankland Sawaya ACH, Barbosa da Silva Cunha I, Marcucci MC (2011) Analytical methods applied to diverse types of Brazilian propolis. Chem Cent J 5:27–36. http://journal.chemistrycentral.com/content/5/1/27
- Nakamura R, Nakamura R, Watanabe K, Oka K, Ohta S, Mishima S, Teshima R (2010) Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis. Int Immunopharmacol 10(9):1107–1112. doi: 10.1016/j.intimp.2010.06.013 PubMedCrossRefGoogle Scholar