, Volume 20, Issue 2, pp 99–101 | Cite as

Flavonoids in propolis acting on mast cell-mediated wound healing

  • Salvatore ChirumboloEmail author
Letter to the Editor

Dear Editor,

Barroso et al. have shown, on the latest issue of Inflammopharmacology, that the topical application of propolis on surgical wounds affected the number of mast cells recruited in these sites, and suggested two well-known anti-inflammatory components present in propolis, namely caffeic acid and artepillin C, as possible active molecules (Borrelli et al. 2002; Paulino et al. 2008). It is widely acknowledged that propolis down-regulates type I allergy and inflammation by affecting mast cells, but the effective components of propolis, which cause these effects, remain still unknown. Propolis components vary depending on the area from which they are collected, mainly because of the genetic variability among wild plants in different geographic regions: variability in phenolics composition may result in different biochemical property of the propolis, depending on the main component active in raw propolis or in its extracts. In Chinese propolis, chrysin, kaempferol and its...


Mast Cell Genistein Propolis Caffeic Acid Phenethyl Ester Chrysin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest

The author declares that he has no conflict of interest.


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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  1. 1.Unit of Geriatry, Department of Medicine, University Laboratory of Medical ResearchUniversity of VeronaVeronaItaly

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