, Volume 20, Issue 2, pp 59–69 | Cite as

Rheumatoid arthritis and the era of biologic therapy



Biologic disease modifying anti-rheumatic drugs have transformed the management of rheumatoid arthritis (RA) since their introduction into clinical practice over a decade ago. Following large-scale clinical trials, a number of biologics, with different mechanisms of action, have been licensed for the condition. In this review, we will summarise the current evidence for biologic use in RA with an emphasis on their efficacy and tolerability. In addition, we will provide a commentary on the current limitations and unmet needs in this area and discuss the future of biologic intervention.


Rheumatoid arthritis Biologic DMARDS Efficacy Tolerability Guidelines 


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Copyright information

© Springer Basel AG 2012

Authors and Affiliations

  • Anshuman P. Malaviya
    • 1
    • 2
  • Andrew J. K. Östör
    • 1
    • 2
  1. 1.School of Clinical MedicineUniversity of CambridgeCambridgeUK
  2. 2.Rheumatology Clinical Research Unit, E6, Level 6, Addenbrooke’s HospitalCambridgeUK

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