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Inflammopharmacology

, Volume 20, Issue 4, pp 219–224 | Cite as

Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves

  • Sunil A. NirmalEmail author
  • Subodh C. Pal
  • Subhash C. Mandal
  • Anuja N. Patil
Research Article

Abstract

Nyctanthes arbortristis Linn. (Oleaceae) is one of the well-known Indian medicinal plant. Various extracts of leaves of the plant were screened for analgesic activity by hot plate test and acetic acid-induced writhings and anti-inflammatory activity by carrageenan-induced hind paw edema method at the dose of 50 mg/kg, i.p. Petroleum ether extract was found to be most active and hence subjected to activity-guided fractionation. Results showed that β-sitosterol (5, 10 and 20 mg/kg, i.p.) was responsible for the significant and dose-dependent activity comparable with the standard extract. β-Sitosterol from N. arbortristis leaves might be responsible for analgesic and anti-inflammatory activity.

Analgesic

Anti-inflammatory Nyctanthes arbortristis Linn β-Sitosterol 

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Copyright information

© Springer Basel AG 2011

Authors and Affiliations

  • Sunil A. Nirmal
    • 1
    Email author
  • Subodh C. Pal
    • 2
  • Subhash C. Mandal
    • 3
  • Anuja N. Patil
    • 1
  1. 1.Department of PharmacognosyPravara Rural College of PharmacyPravaranagarIndia
  2. 2.Department of PharmacognosyNDMVPs College of PharmacyNasikIndia
  3. 3.Department of Pharmaceutical Technology, Pharmacognosy and Phytochemistry Research LaboratoryJadavpur UniversityKolkataIndia

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