, Volume 19, Issue 3, pp 117–129 | Cite as

Lysyl oxidase: a potential target for cancer therapy

  • Siddikuzzaman
  • V. M. Berlin Grace
  • C. Guruvayoorappan


Lysyl oxidases (LysOX; EC, protein-lysine 6-oxidases) are extracellular copper enzymes that catalyze the cross-linking of collagens or elastin in the extracellular matrix (ECM), thereby regulating the tensile strength of tissues. Recent implication of LysOX in cancer, wound healing, cell motility, chemotaxis, and differentiation reflects its remarkable functional diversity and also in the central nervous system pathologies. However, recent reports also demonstrated novel roles for LysOX, including the ability to regulate gene transcription, motility/migration, and cell adhesion. These diverse functions have led researchers to hypothesize that LysOX may have multiple roles affecting both extra- and intracellular cell function(s). Both down and up-regulation of LysOX in tumor tissues and cancer cell lines have been described, suggesting a dual role for LysOX as a tumor suppressor, as well as a metastasis promoter gene. In this review we explain in detail the role of lysyl oxidase in tumor progression and metastasis.


Lysyl oxidase Copper Extra cellular matrix Cancer Tumor suppressor Metastasis promoter 



The Valuable support of Dr. Patrick Gomez, Director, School of Biotechnology and Health Sciences, Karunya University is greatfully acknowledged.


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© Springer Basel AG 2010

Authors and Affiliations

  • Siddikuzzaman
    • 1
  • V. M. Berlin Grace
    • 1
  • C. Guruvayoorappan
    • 1
  1. 1.Department of BiotechnologyKarunya UniversityCoimbatoreIndia

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