Antihypercholesterolaemic effect of ginger rhizome (Zingiber officinale) in rats
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Many herbal medicinal products have potential hypocholesterolaemic activity and encouraging safety profiles. However, only a limited amount of clinical research exists to support their efficacy.
Aim of the work
The present study was designed to evaluate the antihypercholesterolaemic effects of aqueous ginger (Zingiber officinale) infusion in hypercholesterolaemic rat models.
48 rats were used throughout the experiment, which were divided into six groups, eight animals each as follows: normal control group (normal rats which fed with standard diet). After induction of hypercholesterolaemia by feeding rats with high cholesterol diet, the remaining rats were divided into five groups: group 1, hypercholesterolaemic control group (hypercholesterolaemic rats group); groups 2, 3 and 4, rats were given aqueous infusion of ginger (100, 200 and 400 mg/kg, respectively) orally; and group 5, rats were given atorvastatin (0.18 mg/kg) orally as a reference antihypercholesterolaemic drug. The blood was obtained from all groups of rats after being lightly anaesthetized with ether and the following lipid profile [serum total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-C and triglyceride levels] was measured at zero time and 2 and 4 weeks after ginger and atorvastatin treatment, and the risk ratio (TC/HDL-cholesterol) was assessed.
The results revealed that the hypercholesterolaemic rats treated with aqueous ginger infusion in the three doses used after 2 and 4 weeks of treatment induce significant decrease in all lipid profile parameters which were measured and improved the risk ratio.
KeywordsZingiber officinale Hypocholesterolaemic Atorvastatin Lipid profile Rats
- Bhandari U, Sharma JN, Zafar R (1998) The protective action of ethanolic ginger extract in cholesterol-fed rabbits. J Ethnopharmacol 61:167–171Google Scholar
- Budhiraja RD, Sudhir S (1987) Review of biological activity of withanolides. J Sci Ind Res 46:488–491Google Scholar
- Elam MB, Hunninghake DB, Davis KB, Garg R, Johnson C, Egan D, Kostis JB, Sheps DS, Brinton EA (2000) Effect of niacin on lipid and lipoprotein levels and glycaemic control in patients with diabetes and peripheral arterial disease. The ADMIT Study: a randomized trial. JAMA 284:1263–1270Google Scholar
- Flegg HM (1973) An investigation for the determination of serum cholesterol by an enzyme method. Ann Clin Biochem 10:79–84Google Scholar
- Freidwald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifugation. Clin Chem 18:499–502Google Scholar
- Gruenwald J, Brendler T, Jaenicke C (2000) PDR for herbal medicines, 2nd edn. Medical Economics Company, Inc, Montvale, NJGoogle Scholar
- Mary JM, John PK (2000) Agents used in hyperlipidaemia. In: Katzung BG (ed) Basic and clinical pharmacology, 8th edn. McGraw Hill Comp, New York, pp 581–595Google Scholar
- NIH Guide for the Care and Use of Laboratory Animals. (a) DHEW Publication No. (NIH) 8-23, revised 1978 and (b) NIH Publication No. 85-23, revised 1985. US Department of Health, Education and WelfareGoogle Scholar
- Paget GE, Barnes JM (1964) Toxicity test. In: Laurence DR, Bacharach AL (eds) Evaluation of drug activities: pharmacometrics. Academic Press, London, pp 135–166Google Scholar
- Samra G (2001) Healthy hearts and hypoglycemic. Hypoglycemic Health Newslett 17(2):3–6Google Scholar
- Srinivasan K, Sambaiah K (1991) The effect of spices on cholesterol 7a-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int J Vit Nutr Res 61(4):364–369Google Scholar
- Wahlefeld AW (1974) Enzymatic determination of triglycerides. In: Bergmeyer HU (ed) Methods of enzymatic analysis, vol 5. Academic Press, New York, pp 1831–1835Google Scholar
- Watanabe (1958) Volatile components of mulberry leave. J Seri Sci Japan 20:448–452Google Scholar