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Inflammopharmacology

, Volume 17, Issue 1, pp 50–54 | Cite as

Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract

  • M. F. Yam
  • L. F. Ang
  • R. Basir
  • I. M. Salman
  • O. Z. Ameer
  • M. Z. Asmawi
Short Communication

Abstract.

The anti-pyretic activity of a standardized methanol/water (50/50) extract of Orthosiphon stamineus Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1000 mg/kg body weight of SEOS significantly reduced the yeast-induced elevation in body temperature. This effect persisted up to 4 h following the administration of the extract. The anti-pyretic effect of SEOS was comparable with that of paracetamol (acetaminophen in U.S) (150 mg/kg p.o.), a standard anti-pyretic agent. HPLC study revealed that rosmarinic acid, sinensetin, eupatorin and tetramethoxyflavone were present in SEOS in the amounts of 7.58 %, 0.2 %, 0.34 % and 0.24 % respectively. The LD50 of the extract in rats was higher than 5000 mg/kg body weight. Therefore, the present study ascertained that SEOS possesses a significant anti-pyretic activity.

Keywords:

Orthosiphon stamineus Antipyretic effect Rosmarinic acid Eupatorin Sinensetin 3’-hydroxy-5,6,7,4’-tetramethoxyflavone 

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Copyright information

© Birkhäuser Verlag, Basel 2008

Authors and Affiliations

  • M. F. Yam
    • 1
    • 2
  • L. F. Ang
    • 1
  • R. Basir
    • 2
  • I. M. Salman
    • 1
  • O. Z. Ameer
    • 1
  • M. Z. Asmawi
    • 1
  1. 1.School of Pharmaceutical SciencesUniversity Sains MalaysiaMindenMalaysia
  2. 2.Department of Human Anatomy, Faculty of Medicine and Health SciencesUniversiti, Putra MalaysiaSerdangMalaysia

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