International Journal of Thermophysics

, Volume 36, Issue 5–6, pp 849–856 | Cite as

Quantitative Analysis of Hemodynamics in Bruised Skin Using Photothermal Depth Profiling

Article
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Abstract

Pulsed photothermal radiometry (PPTR) allows noninvasive measurement of laser-induced temperature depth profiles, providing useful information on depth distribution of specific absorbers in optically scattering biological tissues. In the present study, PPTR profiling is combined with numerical modeling of light transport in human skin to analyze hemoglobin dynamics in traumatic bruises. Specifically, the influence of regularization degree, applied in iterative reconstruction of temperature depth profiles from PPTR signals measured in bruised volunteers, is studied. The results show that selection between two plausible reconstruction results does not significantly affect the assessed values of key bruise evolution parameters, i.e., hemoglobin mass diffusion and characteristic decomposition time.

Keywords

Bruise Iterative reconstruction process L-curve analysis Pulsed photothermal radiometry Regularization degree Temperature depth profiling 
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References

  1. 1.
    B. Majaron, M. Milanič, W. Jia, J.S. Nelson, L. Vidovič, Lasers Surg. Med. 43, 916 (2011)Google Scholar
  2. 2.
    M. Milanič, B. Majaron, Proc. SPIE 8207, 82070G (2012)ADSGoogle Scholar
  3. 3.
    M. Milanič, B. Majaron, Lasers Surg. Med. 45, 8 (2013)CrossRefGoogle Scholar
  4. 4.
    L. Vidovič, M. Milanič, L.L. Randeberg, B. Majaron, Proc. SPIE 8801, 880104 (2013)Google Scholar
  5. 5.
    L. Vidovič, M. Milanič, B. Majaron, Proc. SPIE 9032, 903202 (2013)Google Scholar
  6. 6.
    T.E. Milner, D.M. Goodman, B.S. Tanenbaum, J.S. Nelson, J. Opt. Soc. Am. A 12, 1479 (1995)ADSCrossRefGoogle Scholar
  7. 7.
    B. Majaron, W. Verkruysse, B.S. Tanenbaum, T.E. Milner, J.S. Nelson, Phys. Med. Biol. 47, 1929 (2002)CrossRefGoogle Scholar
  8. 8.
    B. Majaron, M. Milanič, Phys. Med. Biol. 52, 1089 (2007)CrossRefGoogle Scholar
  9. 9.
    M. Milanič, I. Serša, B. Majaron, Phys. Med. Biol. 54, 2829 (2009)CrossRefGoogle Scholar
  10. 10.
    M. Milanič, B. Majaron, Proc. SPIE 7371, 737100 (2009)Google Scholar
  11. 11.
    C.L. Lawson, Solving Least Squares Problems (Prentice-Hall, Englewood Cliffs, NJ, 1974)MATHGoogle Scholar
  12. 12.
    L.L. Randeberg, O.A. Haugen, R. Haaverstad, L.O. Svaasand, Lasers Surg. Med. 38, 277 (2006)CrossRefGoogle Scholar
  13. 13.
    L. Wang, S.L. Jacques, L. Zheng, Comput. Meth. Programs Biomed. 47, 131 (1995)CrossRefGoogle Scholar
  14. 14.
    M. Milanič, W. Jia, J.S. Nelson, B. Majaron, Lasers Surg. Med. 43, 164 (2011)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Jožef Stefan InstituteLjubljanaSlovenia

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