Emodin Attenuates Severe Acute Pancreatitis via Antioxidant and Anti-inflammatory Activity
There is no specific drug to treat severe acute pancreatitis (SAP), which induces substantial medical and social burden. Many studies have reported the beneficial effects of emodin against SAP in vivo and in vitro. However, the underlying mechanism has been unclear. This paper described the design and implementation of anti-inflammatory and antioxidant activity of emodin. Emodin restored the pathological damage of SAP and simultaneously decreased the high levels of serum amylase, lipase, TNF-α, and IL-18 in the peripheral blood of SAP rat. Emodin reversed reactive oxygen species (ROS) in neutrophils derived from SAP rat. The levels of voltage-dependent anion channel 1 (VDAC1), NOD-like receptor protein 3 (NLRP3), caspase-1, and IL-18 were examined to analyze the change of inflammasome-related mediators between SAP and emodin treatment. These findings suggest that emodin plays its protective role on SAP against oxidative stress and inflammasome signals.
KEY WORDSemodin reactive oxygen species severe acute pancreatitis inflammasome signals
We wish to acknowledge Xue Sui for the help in the flow cytometry assay and Xiaoxin Sun for the arrangement of the daily work in the laboratory.
Shilin Xia and Dong Shang participated in the design of this study. Shilin Xia performed the manuscript review. Yujia Ni exerted the main experiment and performed the statistical analysis. Shilin Xia and Han Liu drafted the manuscript. Qi Zhou, Hong Xiang, and Hua Sui provided assistance for the data acquisition and data analysis. All authors read and approved the final manuscript.
This research was supported by the National Natural Science Foundation of China (No. 81873156 and No. 81703871), Key Project Supported by Clinical Ability Construction of Liaoning Province (No. LNCCC-A03-2015), and Doctoral Start-up Foundation of Liaoning Province (No. 20170520408).
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
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