Advertisement

Pro-inflammatory S100A9 Protein: a Double-Edged Sword in Cancer?

  • Vahid BagheriEmail author
  • Vasso Apostolopoulos
LETTER TO THE EDITOR
  • 57 Downloads

KEY WORDS

S100A9 calgranulin B colon cancer RAGE TLR4 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Goyette, J., and C.L. Geczy. 2011. Inflammation-associated S100 proteins: new mechanisms that regulate function. Amino Acids 41 (4): 821–842.CrossRefGoogle Scholar
  2. 2.
    Farokhzadian, J., P.M. Shahrbabaki, and V. Bagheri. 2017. S100A12-CD36 axis: A novel player in the pathogenesis of atherosclerosis? Cytokine.  https://doi.org/10.1016/j.cyto.2017.07.010.
  3. 3.
    Bagheri, V., and C.L. Geczy. 2017. Comment on “potential effects of calcium binding protein S100A12 on severity evaluation and curative effect of severe acute pancreatitis”. Inflammation 40 (5): 1811–1812.CrossRefGoogle Scholar
  4. 4.
    Bennett, D., M. Salvini, A. Fui, G. Cillis, P. Cameli, M.A. Mazzei, A. Fossi, R.M. Refini, and P. Rottoli. 2019. Calgranulin B and KL-6 in bronchoalveolar lavage of patients with IPF and NSIP. Inflammation.  https://doi.org/10.1007/s10753-018-00955-2.
  5. 5.
    Bargagli, E., C. Olivieri, M. Cintorino, R.M. Refini, N. Bianchi, A. Prasse, and P. Rottoli. 2011. Calgranulin B (S100A9/MRP14): a key molecule in idiopathic pulmonary fibrosis? Inflammation 34 (2): 85–91.CrossRefGoogle Scholar
  6. 6.
    Su, Y.J., F. Xu, J.P. Yu, D.S. Yue, X.B. Ren, and C.L. Wang. 2010. Up-regulation of the expression of S100A8 and S100A9 in lung adenocarcinoma and its correlation with inflammation and other clinical features. Chinese Medical Journal 123 (16): 2215–2220.Google Scholar
  7. 7.
    Li, C., H. Chen, F. Ding, Y. Zhang, A. Luo, M. Wang, and Z. Liu. 2009. A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway. Biochemical Journal 422 (2): 363–372.CrossRefGoogle Scholar
  8. 8.
    Qin, F., Y. Song, Z. Li, L. Zhao, Y. Zhang, and L. Geng. 2010. S100A8/A9 induces apoptosis and inhibits metastasis of CasKi human cervical cancer cells. Pathology & Oncology Research 16 (3): 353–360.CrossRefGoogle Scholar
  9. 9.
    Kim, I.S., and J.S. Lee. 2018. The pro-apoptotic effects of S100A8 and S100A9 in human monocytic leukemia cells, THP-1. Biomedical Science Letters 24 (2): 134–137.CrossRefGoogle Scholar
  10. 10.
    Turovskaya, O., D. Foell, P. Sinha, T. Vogl, R. Newlin, J. Nayak, M. Nguyen, A. Olsson, P.P. Nawroth, A. Bierhaus, N. Varki, M. Kronenberg, H.H. Freeze, and G. Srikrishna. 2008. RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis 29 (10): 2035–2043.CrossRefGoogle Scholar
  11. 11.
    Ichikawa, M., R. Williams, L. Wang, T. Vogl, and G. Srikrishna. 2011. S100A8/A9 activate key genes and signaling pathways in colon tumor progression. Molecular Cancer Research 9 (2): 133–148.CrossRefGoogle Scholar
  12. 12.
    Kim, K., K.H. Kim, K. Roh, B.C. Yoo, J.L. Ku, Y.K. Shin, J.Y. Cho, M. Kim, M.H. Kwon, S.H. Goh, H.J. Chang, and J.H. Oh. 2016. Antitumor effects of calgranulin B internalized in human colon cancer cells. Oncotarget 7 (15): 20368–20380.Google Scholar
  13. 13.
    Low, D., R. Subramaniam, L. Lin, T. Aomatsu, A. Mizoguchi, A. Ng, A.K. DeGruttola, C.G. Lee, J.A. Elias, A. Andoh, M. Mino-Kenudson, and E. Mizoguchi. 2015. Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9. Oncotarget 6 (34): 36535–36550.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Molecular Medicine Research Center, Research Institute of Basic Medical SciencesRafsanjan University of Medical SciencesRafsanjanIran
  2. 2.Institute for Health and SportVictoria UniversityMelbourneAustralia

Personalised recommendations